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Annex II Entry 163 15/10/2010

Emetine, its salts and derivatives

Emetine, its salts and derivatives is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 163

Chemical identity and properties

PubChem 2D chemical structure for CAS 483-18-1
CAS 483-18-1PubChem CID 10219

Emetine

Emetine is a pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. It has a role as an emetic, an anticoronaviral agent, an antiamoebic agent, an antiviral agent, an antiinfective agent, an antineoplastic agent, an antiprotozoal drug, an antimalarial, a protein synthesis inhibitor, a plant metabolite, an expectorant and an autophagy inhibitor. It is an isoquinoline alkaloid and a pyridoisoquinoline. It is functionally related to a cephaeline. It is a conjugate base of an emetine(2+). It derives from a hydride of an emetan. — ChEBI

IUPAC name
(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine
Molecular formula
C29H40N2O4
Molecular weight
480.6 g/mol
Exact mass
480.29880776 Da
XLogP3
4.7
Topological polar surface area
52.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
4

Also known as

EmetinCephaeline methyl ether(-)-EmetineMethyl cephaeline6',7',10,11-TetramethoxyemetanCephaline-O-methyl etherEmetinumEmetan, 6',7',10,11-tetramethoxy-
16 more reported names
NSC-33669X8D5EPO80MCHEBI:4781IpecineMethylcephaeline(2S,3R,11bS)-2-(((1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo(a)quinolizineRefChem:136683207-592-1Emetine (>90%)TCMDC-125531GNF-PF-196Emetine dihydrochloride hydrateEmetine [BAN]CAS-483-18-1HSDB 2150EINECS 207-592-1
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Emetine, its salts and derivatives

Regulatory information

Regulation

(EC) 2009/1223

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Key data

CAS
483-18-1
EC
207-592-1
Annex
II
Entry number
163

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Emetine, its salts and derivatives

Emetine, its salts and derivatives is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Emetine, its salts and derivatives is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 483-18-1 is the unique numerical identifier assigned to Emetine, its salts and derivatives by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Emetine, its salts and derivatives

This page summarizes one Annex II record for Emetine, its salts and derivatives from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Emetine, its salts and derivatives, but confirm any final regulatory decision against the current official annex wording and source files.

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