Emetine
Emetine is a pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. It has a role as an emetic, an anticoronaviral agent, an antiamoebic agent, an antiviral agent, an antiinfective agent, an antineoplastic agent, an antiprotozoal drug, an antimalarial, a protein synthesis inhibitor, a plant metabolite, an expectorant and an autophagy inhibitor. It is an isoquinoline alkaloid and a pyridoisoquinoline. It is functionally related to a cephaeline. It is a conjugate base of an emetine(2+). It derives from a hydride of an emetan. — ChEBI
- IUPAC name
- (2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine
- Molecular formula
- C29H40N2O4
- Molecular weight
- 480.6 g/mol
- Exact mass
- 480.29880776 Da
- XLogP3
- 4.7
- Topological polar surface area
- 52.2 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 4
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:4781
- ChEMBL:CHEMBL50588
- EPA DTXSID:DTXSID5022980
- PubMed:32545799
- PubMed:30028873
- PubMed:27336364
- PubMed:24077524
- PubMed:23195733
- PubMed:23168082
- PubMed:23074898
- PubMed:22895718
- PubMed:22867001
- PubMed:22860455
- PubMed:22701146
- PubMed:22661859
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.