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Annex II Entry 167 05/02/2014

4-Aminobenzoic acid and its esters, with the free amino group

4-Aminobenzoic acid and its esters, with the free amino group is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 167

Chemical identity and properties

PubChem 2D chemical structure for CAS 150-13-0
CAS 150-13-0PubChem CID 978

4-Aminobenzoic Acid

4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an allergen, a plant metabolite and an Escherichia coli metabolite. It is functionally related to a benzoic acid. It is a conjugate base of a 4-carboxyanilinium. It is a conjugate acid of a 4-aminobenzoate. It is a tautomer of a 4-ammoniobenzoate. — ChEBI

IUPAC name
4-aminobenzoic acid
Molecular formula
C7H7NO2
Molecular weight
137.14 g/mol
Exact mass
137.047678466 Da
XLogP3
0.8
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

p-aminobenzoic acidPABAVitamin BXp-Carboxyanilinepara-aminobenzoic acidSunbrella4-CarboxyanilineParaminol
16 more reported names
PabacydAmbenBenzoic acid, 4-amino-p-CarboxyphenylaminePabafilmPabamineParanateRomavitVitamin H'Bacterial vitamin H11-Amino-4-carboxybenzeneAnticanitic vitaminChromotrichia factorRVPaba LipstickTrichochromogenic factorPapacidum
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Aminobenzoic acid and its esters, with the free amino group

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

Identified ingredients

Key data

CAS
150-13-0
EC
205-753-0
Annex
II
Entry number
167

Inventory links for 4-Aminobenzoic acid and its esters, with the free amino group

Inventory Restriction reference
Ref 84499

BUTYL PABA

CAS: 94-25-7
EC: 202-317-1
Inventory Restriction reference
Ref 84653

ETHYL PABA

CAS: 94-09-7
EC: 202-303-5
Inventory Restriction reference
Ref 56220

GLYCERYL PABA

CAS: 136-44-7
EC: 205-244-3
Inventory Restriction reference
Ref 35778

PABA

CAS: 150-13-0
EC: 205-753-0

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 4-Aminobenzoic acid and its esters, with the free amino group

4-Aminobenzoic acid and its esters, with the free amino group is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 7 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4-Aminobenzoic acid and its esters, with the free amino group is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 150-13-0 is the unique numerical identifier assigned to 4-Aminobenzoic acid and its esters, with the free amino group by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-Aminobenzoic acid and its esters, with the free amino group

This page summarizes one Annex II record for 4-Aminobenzoic acid and its esters, with the free amino group from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Aminobenzoic acid and its esters, with the free amino group, but confirm any final regulatory decision against the current official annex wording and source files.

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