EU cosmetic ingredients, restrictions and safety

Annex II Entry 167 05/02/2014

4-Aminobenzoic acid and its esters, with the free amino group

4-Aminobenzoic acid and its esters, with the free amino group is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare

Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 167

Record details

Chemical name

4-Aminobenzoic acid and its esters, with the free amino group

Regulatory information

Regulation

(EC) 2013/344

Identified ingredients

Key data

CAS

EC

Annex

Entry number

167

Inventory links for 4-Aminobenzoic acid and its esters, with the free amino group

Inventory Restriction reference

Ref 74189

ALLANTOIN PABA

CAS: 4207-42-5

Inventory Restriction reference

Ref 84499

BUTYL PABA

CAS: 94-25-7

EC: 202-317-1

Inventory Restriction reference

Ref 85165

DEFINED CELL CULTURE MEDIA

Inventory Restriction reference

Ref 84653

ETHYL PABA

CAS: 94-09-7

EC: 202-303-5

Inventory Restriction reference

Ref 56220

GLYCERYL PABA

CAS: 136-44-7

EC: 205-244-3

Inventory Restriction reference

Ref 35778

PABA

CAS: 150-13-0

EC: 205-753-0

Inventory Restriction reference

Ref 96317

PABA SH-PENTAPEPTIDE-9

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 166

Nearby record in the same annex

Eserine or physostigmine and its salts

CAS: 57-47-6

EC: 200-332-8

Annex II 168

Nearby record in the same annex

Choline salts and their esters e.g. choline chloride (INN)

CAS: 67-48-1

EC: 200-655-4

Annex II 165

Nearby record in the same annex

Oxanamide (INN) and its derivatives

CAS: 126-93-2

Annex II 169

Nearby record in the same annex

Caramiphen (INN) and its salts

CAS: 77-22-5

EC: 201-013-6

Annex II 164

Nearby record in the same annex

Ephedrine and its salts

CAS: 299-42-3

EC: 206-080-5

Annex II 170

Nearby record in the same annex

Diethyl 4-nitrophenyl phosphate (Paraoxon - ISO)

CAS: 311-45-5

EC: 206-221-0

Annex II 163

Nearby record in the same annex

Emetine, its salts and derivatives

CAS: 483-18-1

EC: 207-592-1

Annex II 171

Nearby record in the same annex

Metethoheptazine (INN) and its salts

CAS: 509-84-2

Annex II 162

Nearby record in the same annex

Disulfiram (INN); thiram (ISO) (INN)

CAS: 97-77-8 / 137-26-8

EC: 202-607-8 / 205-286-2

Annex II 172

Nearby record in the same annex

Oxpheneridine (INN) and its salts

CAS: 546-32-7

Annex II 161

Nearby record in the same annex

Probenecid (INN)

CAS: 57-66-9

EC: 200-344-3

Annex II 173

Nearby record in the same annex

Ethoheptazine (INN) and its salts

CAS: 77-15-6

EC: 201-007-3

What Annex II means for 4-Aminobenzoic acid and its esters, with the free amino group

4-Aminobenzoic acid and its esters, with the free amino group is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009. No concentration limit applies — the presence of this substance in any cosmetic product placed on the EU market is not permitted regardless of use level.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 7 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4-Aminobenzoic acid and its esters, with the free amino group is listed in Annex II of EU Cosmetics Regulation 1223/2009 as a prohibited substance. It must not be present in any cosmetic product placed on the EU market at any concentration.

CAS 150-13-0 is the unique numerical identifier assigned to 4-Aminobenzoic acid and its esters, with the free amino group by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Open INCI Checker

Source note for Annex II record 4-Aminobenzoic acid and its esters, with the free amino group

This page summarizes one Annex II record for 4-Aminobenzoic acid and its esters, with the free amino group from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Aminobenzoic acid and its esters, with the free amino group, but confirm any final regulatory decision against the current official annex wording and source files.

View sources View updates

Tools & next steps

Check your formula

Paste a full INCI list to detect 4-Aminobenzoic acid and its esters, with the free amino group and other flagged EU annex records in one pass.

Compare entries

Compare 4-Aminobenzoic acid and its esters, with the free amino group side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.