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Annex II Entry 162 20/10/2010

Disulfiram (INN); thiram (ISO) (INN)

Disulfiram (INN); thiram (ISO) (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 162

Chemical identity and properties

PubChem 2D chemical structure for CAS 137-26-8
CAS 137-26-8PubChem CID 5455

Thiram

Thiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment. It has a role as an antibacterial drug, an antiseptic drug and an antifungal agrochemical. It contains a dimethyldithiocarbamate. It is functionally related to a dimethyldithiocarbamic acid. — ChEBI

IUPAC name
dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
Molecular formula
C6H12N2S4
Molecular weight
240.4 g/mol
Exact mass
239.98833309 Da
XLogP3
1.7
Topological polar surface area
121.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Tetramethylthiuram disulfideThiuramTMTDRezifilmPomarsolThirameArasanFernasan
16 more reported names
NobecutanNormersanAapirolPuralinSpotreteThiosanThirasanTetrathiuram disulfideTetramethylthiuramFalitiramFormalsolHexathirKregasanMercuramSadoplonTetrasipton
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 97-77-8
CAS 97-77-8PubChem CID 3117

Disulfiram

Disulfiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. It has a role as a ferroptosis inducer, a fungicide, an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor, an antineoplastic agent, an EC 3.1.1.8 (cholinesterase) inhibitor, an angiogenesis inhibitor, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an apoptosis inducer, a NF-kappaB inhibitor and an EC 3.1.1.1 (carboxylesterase) inhibitor. It is an organic disulfide and an organosulfur acaricide. — ChEBI

IUPAC name
diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Molecular formula
C10H20N2S4
Molecular weight
296.5 g/mol
Exact mass
296.05093334 Da
XLogP3
3.9
Topological polar surface area
121.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Tetraethylthiuram disulfideAntabuseBis(diethylthiocarbamoyl) disulfideEsperalTeturamAlcophobinAntabusAnticol
16 more reported names
ExhorranAbstinylAntadixAntietilAversanDicupralRefusalTeturaminHocaTETDEthyl ThiramEthyldithiurameAbstensilAbstinilAntaethylAntalcol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Disulfiram (INN); thiram (ISO) (INN)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
97-77-8 / 137-26-8
EC
202-607-8 / 205-286-2
Annex
II
Entry number
162

Inventory links for Disulfiram (INN); thiram (ISO) (INN)

Inventory Restriction reference
Ref 84655

THIRAM

CAS: 137-26-8
EC: 205-286-2

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Disulfiram (INN); thiram (ISO) (INN)

Disulfiram (INN); thiram (ISO) (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Disulfiram (INN); thiram (ISO) (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 97-77-8 / 137-26-8 is the unique numerical identifier assigned to Disulfiram (INN); thiram (ISO) (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Disulfiram (INN); thiram (ISO) (INN)

This page summarizes one Annex II record for Disulfiram (INN); thiram (ISO) (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Disulfiram (INN); thiram (ISO) (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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