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Annex II Entry 1548 CMR30/07/2020

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2]

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1548
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 65195-55-3
CAS 65195-55-3PubChem CID 6434889

avermectin B1a

Avermectin B1a is an avermectin. — ChEBI

IUPAC name
(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
Molecular formula
C48H72O14
Molecular weight
873.1 g/mol
Exact mass
872.49220697 Da
XLogP3
3.8
Topological polar surface area
170.0 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
14
Covalent units
1
Defined stereocentres
20

Also known as

Abamectin B1aabamectin component B1a5-O-Demethylavermectin A1aAvermectin B(1)aAvermectin A1a, 5-O-demethyl-Antibiotic C 076B1aCaswell No. 063ABAbamectin komponente B1a
16 more reported names
K54ZMM929KCHEBI:29534RefChem:6604C-076avermectin B1a (purity >=80 %)265-610-3Ivermectin EP Impurity AC48H72O14DSSTox_CID_3892DSSTox_RID_77221DSSTox_GSID_23892Abamectine [French]Abamectinum [Latin]Abamectina [Spanish]EINECS 265-610-3Antibiotic C 076A1a, 5-O-demethyl-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 71751-41-2
CAS 71751-41-2PubChem CID 9920327

Abamectin

Abamectin appears as odorless off-white to yellow crystals from methanol. Does not hydrolyze in water at pH 3, 5, 7. Used as an acaricide and insecticide. — CAMEO Chemicals

IUPAC name
(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one;(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethyl-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
Molecular formula
C95H142O28
Molecular weight
1732.1 g/mol
Exact mass
1731.97211870 Da
Topological polar surface area
340.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
28
Covalent units
2
Defined stereocentres
39

Also known as

AvomecAbamectinaAbamectineBovitinDoratectDuomectinDuotinAgri-Mek
16 more reported names
MK-936AbamectinumNSC-758202MK-0936AgrimekVertimecAffirmZephyrAvidMK 936Avermectin B(sub 1)vertimec 18ECAVID ECEndectoParafoilVertimil
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2]

Chemical / IUPAC name

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2]

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
71751-41-2 [1] 65195-55-3 [2]
EC
615-339-5 [1] 265-610-3 [2]
Annex
II
Entry number
1548

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1547
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Tetrahydrofuran

CAS: 109-99-9
EC: 203-726-8
Annex II 1544
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Indium phosphide

CAS: 22398-80-7
EC: 244-959-5
Annex II 1542
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Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…

CAS: 68607-11-4 [1]; 68783-06-2 [2]; 68814-67-5 [3]; 68814-90-4 [4]; 68911-58-0 [5]; 68911-59-1 [6]; 68919-01-7 [7]; 68919-02-8 [8]; 68919-03-9 [9]; 68919-04-0 [10]; 68919-07-3 [11]; 68919-08-4 [12]; 68919-11-9 [13]; 68919-12-0 [14]; 68952-79-4 [15]; 68952-80-7 [16]; 68955-33-9 [17]; 68989-88-8 [18]; 92045-15-3 [19]; 92045-16-4 [20]; 92045-17-5 [21]; 92045-18-6 [22]; 92045-19-7 [23]; 92045-20-0 [24]; 68131-75-9 [25]; 68307-98-2 [26]; 68307-99-3 [27]; 68308-00-9 [28]; 68308-01-0 [29]; 68308-10-1 [30]; 68308-03-2 [31]; 68308-04-3 [32]; 68308-05-4 [33]; 68308-06-5 [34]; 68308-07-6 [35]; 68308-09-8 [36]; 68308-11-2 [37]; 68308-12-3 [38]; 68409-99-4 [39]; 68475-57-0 [40]; 68475-58-1 [41]; 68475-59-2 [42]; 68475-60-5 [43]; 68476-26-6 [44]; 68476-29-9 [45]; 68476-40-4 [46]; 68476-42-6 [47]; 68476-49-3 [48]; 68476-85-7 [49]; 68476-86-8 [50]; 68477-33-8 [51]; 68477-35-0 [52]; 68477-69-0 [53]; 68477-70-3 [54]; 68477-71-4 [55]; 68477-72-5 [56]; 68308-08-7 [57];
EC: 271-750-6 [1]; 272-182-1 [2]; 272-338-9 [3]; 272-343-6 [4]; 272-775-5 [5]; 272-776-0 [6]; 272-873-8 [7]; 272-874-3 [8]; 272-875-9 [9]; 272-876-4 [10]; 272-880-6 [11]; 272-881-1 [12]; 272-884-8 [13]; 272-885-3 [14]; 273-173-5 [15]; 273-174-0 [16]; 273-269-7 [17]; 273-563-5 [18]; 295-397-2 [19]; 295-398-8 [20]; 295-399-3 [21]; 295-400-7 [22]; 295-401-2 [23]; 295-402-8 [24]; 268-629-5 [25]; 269-617-2 [26]; 269-618-8 [27]; 269-619-3 [28]; 269-620-9 [29]; 269-630-3 [30]; 269-623-5 [31]; 269-624-0 [32]; 269-625-6 [33]; 269-626-1 [34]; 269-627-7 [35]; 269-629-8 [36]; 269-631-9 [37]; 269-632-4 [38]; 270-071-2 [39]; 270-651-5 [40]; 270-652-0 [41]; 270-653-6 [42]; 270-654-1 [43]; 270-667-2 [44]; 270-670-9 [45]; 270-681-9 [46]; 270-682-4 [47]; 270-689-2 [48]; 270-704-2 [49]; 270-705-8 [50]; 270-724-1 [51]; 270-726-2 [52]; 270-750-3 [53]; 270-751-9 [54]; 270-752-4 [55]; 270-754-5 [56]; 269-628-2 [57];

What Annex II means for Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2]

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 71751-41-2 [1] 65195-55-3 [2] is the unique numerical identifier assigned to Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2]

This page summarizes one Annex II record for Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; Avermectin B1a [2], but confirm any final regulatory decision against the current official annex wording and source files.

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