Annex II
Entry 1544
CMR30/07/2020
Indium phosphide
Indium phosphide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1544
CMR
Chemical identity and properties
CAS 22398-80-7PubChem CID 31170
Indium phosphide
Indium phosphide is a phosphide of indium. It is a semiconductor used in high-power and high-frequency electronics because of its superior electron velocity with respect to the more common semiconductors silicon and gallium arsenide. It also has a direct bandgap, making it useful for optoelectronics devices like laser diodes. Metal phosphides are hydrolysed to phosphine upon contact with water or stomach acid. Phosphine is a colorless, flammable, explosive, and toxic gas. (L980, L986) — Toxin and Toxin Target Database (T3DB)
- IUPAC name
- indiganylidynephosphane
- Molecular formula
- InP
- Molecular weight
- 145.792 g/mol
- Exact mass
- 145.8776408 Da
- Topological polar surface area
- 0.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 0
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Indium phosphide (InP)Indium(III) phosphideIndium monophosphideSD36LG60G1Indium (III) phosphideRefChem:148161244-959-5HSDB 6935
13 more reported names
EINECS 244-959-5UNII-SD36LG60G1CCRIS 8799Indium(III)phosphideDSSTox_CID_11444DSSTox_RID_78875DSSTox_GSID_31444INDIUM PHOSPHIDE [MI]INDIUM PHOSPHIDE [IARC]Tox21_302280CAS-22398-80-7Indium(III) phosphide, flakess, 3-20 mesh, 99.998% metals basisIndium(III) phosphide, pieces, 3-20 mesh, 99.998% trace metals basis
External database identifiers
- EPA DTXSID:DTXSID3031444
- PubMed:25527823
- PubMed:11921183
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Indium phosphide
Chemical / IUPAC name
Indium phosphide
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | ✓ | — | — |
| Cat. 2 | — | — | ✓ |
Key data
Related records for Indium phosphide
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Annex II
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Annex II
1542
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EC: 271-750-6 [1]; 272-182-1 [2]; 272-338-9 [3]; 272-343-6 [4]; 272-775-5 [5]; 272-776-0 [6]; 272-873-8 [7]; 272-874-3 [8]; 272-875-9 [9]; 272-876-4 [10]; 272-880-6 [11]; 272-881-1 [12]; 272-884-8 [13]; 272-885-3 [14]; 273-173-5 [15]; 273-174-0 [16]; 273-269-7 [17]; 273-563-5 [18]; 295-397-2 [19]; 295-398-8 [20]; 295-399-3 [21]; 295-400-7 [22]; 295-401-2 [23]; 295-402-8 [24]; 268-629-5 [25]; 269-617-2 [26]; 269-618-8 [27]; 269-619-3 [28]; 269-620-9 [29]; 269-630-3 [30]; 269-623-5 [31]; 269-624-0 [32]; 269-625-6 [33]; 269-626-1 [34]; 269-627-7 [35]; 269-629-8 [36]; 269-631-9 [37]; 269-632-4 [38]; 270-071-2 [39]; 270-651-5 [40]; 270-652-0 [41]; 270-653-6 [42]; 270-654-1 [43]; 270-667-2 [44]; 270-670-9 [45]; 270-681-9 [46]; 270-682-4 [47]; 270-689-2 [48]; 270-704-2 [49]; 270-705-8 [50]; 270-724-1 [51]; 270-726-2 [52]; 270-750-3 [53]; 270-751-9 [54]; 270-752-4 [55]; 270-754-5 [56]; 269-628-2 [57];
Annex II
1546
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EC: 247-148-4 [1] 221-695-9 [2]
Annex II
1541
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EC: 285-076-5 [1]; 283-484-8 [2]; 284-898-1 [3]; 295-310-8 [4]; 310-166-9 [5]; 310-167-4 [6]; 292-612-1 [7]; 292-627-3 [8]; 309-985-4 [9]; 309-972-3 [10]; 295-309-2 [11]; 292-628-9 [12]; 284-901-6 [13]; 310-165-3 [14]; 292-603-2 [15]; 292-604-8 [16]; 295-505-8 [17]; 295-275-9 [18]; 295-276-4 [19]; 295-278-5 [20]; 309-889-2 [21]; 310-191-5 [22]; 284-881-9 [23]; 292-610-0 [24]; 266-017-2 [25]; 292-611-6 [26]; 292-629-4 [27]; 266-019-3 [28]; 309-888-7 [29]; 295-536-7 [30]; 306-251-5 [31]; 284-892-9 [32]; 284-893-4 [33]; 284-895-5 [34]; 284-891-3 [35]; 284-896-0 [36]; 270-713-1 [37]; 271-418-0 [38]; 293-435-2 [39]; 295-540-9 [40]; 302-662-9 [41]; 292-623-1 [42]; 271-020-7 [43]; 274-560-1 [44]; 295-544-0 [45]; 309-745-9 [46]; 309-748-5 [47]; 309-749-0 [48]; 277-567-8 [49]; 272-361-4 [50]; 266-020-9 [51]; 266-018-8 [52];
Annex II
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Annex II
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Annex II
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Annex II
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Annex II
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What Annex II means for Indium phosphide
Indium phosphide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Yes. Indium phosphide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 22398-80-7 is the unique numerical identifier assigned to Indium phosphide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
Indium phosphide has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record Indium phosphide
This page summarizes one Annex II record for Indium phosphide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Indium phosphide, but confirm any final regulatory decision against the current official annex wording and source files.
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