Annex II
Entry 1545
CMR30/07/2020
Trixylyl phosphate
Trixylyl phosphate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1545
CMR
Chemical identity and properties
CAS 25155-23-1PubChem CID 19736
Trixylenyl phosphate
Toxic by ingestion and skin absorption when pure. Produces phosphorus oxide gases during combustion. Primary hazard is threat to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates soil to contaminate groundwater and nearby waterways. — CAMEO Chemicals
- IUPAC name
- tris(2,4-dimethylphenyl) phosphate
- Molecular formula
- C24H27O4P
- Molecular weight
- 410.4 g/mol
- Exact mass
- 410.16469634 Da
- XLogP3
- 7.2
- Topological polar surface area
- 44.8 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Tri-xylenyl phosphateXylyl phosphateCoalite NTPPhosflex 179Reofos 95Xylenol, phosphate (3:1)Tri-dimethyl phenyl phosphateTris(dimethylphenol) phosphate
16 more reported names
Phosphoric acid, trixylyl esterDimethylphenol phosphate (3:1)7M08K25Q1JPhenol, dimethyl-, phosphate (3:1)ANTIBLAZE TXPDURAD TXPFYRQUEL LRefChem:192072ANTIBLAZE 524DURAD 220XPHOSPHORIC ACID TRIXYLYL ESTER246-677-8Trixylyl phosphate3862-12-2Phenol, dimethyl-, 1,1',1''-phosphateTri-2,4-xylyl phosphate
External database identifiers
- EPA DTXSID:DTXSID80959466
- PubMed:38603619
- PubMed:21362439
- PubMed:18809204
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Trixylyl phosphate
Chemical / IUPAC name
Trixylyl phosphate
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | — | — | ✓ |
Key data
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Annex II
1551
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What Annex II means for Trixylyl phosphate
Trixylyl phosphate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Yes. Trixylyl phosphate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 25155-23-1 is the unique numerical identifier assigned to Trixylyl phosphate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
Trixylyl phosphate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record Trixylyl phosphate
This page summarizes one Annex II record for Trixylyl phosphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Trixylyl phosphate, but confirm any final regulatory decision against the current official annex wording and source files.
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