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Annex II Entry 1546 CMR30/07/2020

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2]

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1546
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 25637-99-4
CAS 25637-99-4PubChem CID 33121

Hexabromocyclododecane

Hexabromocyclododecane is a white powder. Insoluble in water. (NTP, 1992) — CAMEO Chemicals

IUPAC name
1,3,5,7,9,11-hexabromocyclododecane
Molecular formula
C12H18Br6
Molecular weight
641.7 g/mol
Exact mass
641.64473 Da
XLogP3
7.1
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

SAYTEX HBCDRefChem:217126PYROVATEX 38875I9835JO3M247-148-4Cyclododecane, hexabromo-HBCDDHexabromocyclododecane (Mixture of Diastereomers)
3 more reported names
LEOCKULGXOQRTQ-UHFFFAOYSA-NMSK2337-100BHexabromocyclododecane Solution in Acetone, 100ug/mL
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3194-55-6
CAS 3194-55-6PubChem CID 18529

1,2,5,6,9,10-Hexabromocyclododecane

1,2,5,6,9,10-hexabromocyclododecane is a bromoalkane consisting of cyclododecane bearing six bromo substituents at positions 1, 2, 5, 6, 9 and 10. It has a role as a xenobiotic, a neurotoxin and a persistent organic pollutant. It is a brominated flame retardant, a bromohydrocarbon and a bromoalkane. — ChEBI

IUPAC name
1,2,5,6,9,10-hexabromocyclododecane
Molecular formula
C12H18Br6
Molecular weight
641.7 g/mol
Exact mass
641.64473 Da
XLogP3
7.1
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

Cyclododecane, 1,2,5,6,9,10-hexabromo-1,2,5,6,9,10-Hexabromocyclodecane66OON1WWOSPYROGUARD SR 104BROMKAL 73-6DCHEBI:134063RefChem:71567221-695-9
16 more reported names
HBCDC12H18Br6CAS-3194-55-6HSDB 6110EINECS 221-695-9UNII-66OON1WWOSSaytex HBCD-LM(1R,2S,5R,6R,9R,10S)-rel-1,2,5,6,9,10-Hexabromocyclododecane- d18HEXABROMOCYCLODODECANE [MI]Tox21_201402Tox21_303176DB-0685531,2,5,6,9,10-HBCDH05441,2,5,6,9,10-Hexabromocyclododecane, 95%1,2,5,6,9,10-HEXABROMOCYCLODODECANE [HSDB]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2]

Chemical / IUPAC name

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2]

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
25637-99-4 [1] 3194-55-6 [2]
EC
247-148-4 [1] 221-695-9 [2]
Annex
II
Entry number
1546

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1547
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Tetrahydrofuran

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EC: 203-726-8
Annex II 1544
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Indium phosphide

CAS: 22398-80-7
EC: 244-959-5
Annex II 1542
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Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…

CAS: 68607-11-4 [1]; 68783-06-2 [2]; 68814-67-5 [3]; 68814-90-4 [4]; 68911-58-0 [5]; 68911-59-1 [6]; 68919-01-7 [7]; 68919-02-8 [8]; 68919-03-9 [9]; 68919-04-0 [10]; 68919-07-3 [11]; 68919-08-4 [12]; 68919-11-9 [13]; 68919-12-0 [14]; 68952-79-4 [15]; 68952-80-7 [16]; 68955-33-9 [17]; 68989-88-8 [18]; 92045-15-3 [19]; 92045-16-4 [20]; 92045-17-5 [21]; 92045-18-6 [22]; 92045-19-7 [23]; 92045-20-0 [24]; 68131-75-9 [25]; 68307-98-2 [26]; 68307-99-3 [27]; 68308-00-9 [28]; 68308-01-0 [29]; 68308-10-1 [30]; 68308-03-2 [31]; 68308-04-3 [32]; 68308-05-4 [33]; 68308-06-5 [34]; 68308-07-6 [35]; 68308-09-8 [36]; 68308-11-2 [37]; 68308-12-3 [38]; 68409-99-4 [39]; 68475-57-0 [40]; 68475-58-1 [41]; 68475-59-2 [42]; 68475-60-5 [43]; 68476-26-6 [44]; 68476-29-9 [45]; 68476-40-4 [46]; 68476-42-6 [47]; 68476-49-3 [48]; 68476-85-7 [49]; 68476-86-8 [50]; 68477-33-8 [51]; 68477-35-0 [52]; 68477-69-0 [53]; 68477-70-3 [54]; 68477-71-4 [55]; 68477-72-5 [56]; 68308-08-7 [57];
EC: 271-750-6 [1]; 272-182-1 [2]; 272-338-9 [3]; 272-343-6 [4]; 272-775-5 [5]; 272-776-0 [6]; 272-873-8 [7]; 272-874-3 [8]; 272-875-9 [9]; 272-876-4 [10]; 272-880-6 [11]; 272-881-1 [12]; 272-884-8 [13]; 272-885-3 [14]; 273-173-5 [15]; 273-174-0 [16]; 273-269-7 [17]; 273-563-5 [18]; 295-397-2 [19]; 295-398-8 [20]; 295-399-3 [21]; 295-400-7 [22]; 295-401-2 [23]; 295-402-8 [24]; 268-629-5 [25]; 269-617-2 [26]; 269-618-8 [27]; 269-619-3 [28]; 269-620-9 [29]; 269-630-3 [30]; 269-623-5 [31]; 269-624-0 [32]; 269-625-6 [33]; 269-626-1 [34]; 269-627-7 [35]; 269-629-8 [36]; 269-631-9 [37]; 269-632-4 [38]; 270-071-2 [39]; 270-651-5 [40]; 270-652-0 [41]; 270-653-6 [42]; 270-654-1 [43]; 270-667-2 [44]; 270-670-9 [45]; 270-681-9 [46]; 270-682-4 [47]; 270-689-2 [48]; 270-704-2 [49]; 270-705-8 [50]; 270-724-1 [51]; 270-726-2 [52]; 270-750-3 [53]; 270-751-9 [54]; 270-752-4 [55]; 270-754-5 [56]; 269-628-2 [57];
Annex II 1541
Nearby record in the same annex

Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…

CAS: 85029-51-2 [1]; 84650-04-4 [2]; 84989-09-3 [3]; 91995-49-2 [4]; 121620-47-1 [5]; 121620-48-2 [6]; 90640-90-7 [7]; 90641-04-6 [8]; 101896-27-9 [9]; 101794-91-6 [10]; 91995-48-1 [11]; 90641-05-7 [12]; 84989-12-8 [13]; 121620-46-0 [14]; 90640-81-6 [15]; 90640-82-7 [16]; 92061-92-2 [17]; 91995-15-2 [18]; 91995-16-3 [19]; 91995-17-4 [20]; 101316-87-4 [21]; 122384-78-5 [22]; 84988-93-2 [23]; 90640-88-3 [24]; 65996-83-0 [25]; 90640-89-4 [26]; 90641-06-8 [27]; 65996-85-2 [28]; 101316-86-3 [29]; 92062-22-1 [30]; 96690-55-0 [31]; 84989-04-8 [32]; 84989-05-9 [33]; 84989-06-0 [34]; 84989-03-7 [35]; 84989-07-1 [36]; 68477-23-6 [37]; 68555-24-8 [38]; 91079-47-9 [39]; 92062-26-5 [40]; 94114-29-1 [41]; 90641-00-2 [42]; 68513-87-1 [43]; 70321-67-4 [44]; 92062-29-8 [45]; 100801-63-6 [46]; 100801-65-8 [47]; 100801-66-9 [48]; 73665-18-6 [49]; 68815-21-4 [50]; 65996-86-3 [51]; 65996-84-1 [52];
EC: 285-076-5 [1]; 283-484-8 [2]; 284-898-1 [3]; 295-310-8 [4]; 310-166-9 [5]; 310-167-4 [6]; 292-612-1 [7]; 292-627-3 [8]; 309-985-4 [9]; 309-972-3 [10]; 295-309-2 [11]; 292-628-9 [12]; 284-901-6 [13]; 310-165-3 [14]; 292-603-2 [15]; 292-604-8 [16]; 295-505-8 [17]; 295-275-9 [18]; 295-276-4 [19]; 295-278-5 [20]; 309-889-2 [21]; 310-191-5 [22]; 284-881-9 [23]; 292-610-0 [24]; 266-017-2 [25]; 292-611-6 [26]; 292-629-4 [27]; 266-019-3 [28]; 309-888-7 [29]; 295-536-7 [30]; 306-251-5 [31]; 284-892-9 [32]; 284-893-4 [33]; 284-895-5 [34]; 284-891-3 [35]; 284-896-0 [36]; 270-713-1 [37]; 271-418-0 [38]; 293-435-2 [39]; 295-540-9 [40]; 302-662-9 [41]; 292-623-1 [42]; 271-020-7 [43]; 274-560-1 [44]; 295-544-0 [45]; 309-745-9 [46]; 309-748-5 [47]; 309-749-0 [48]; 277-567-8 [49]; 272-361-4 [50]; 266-020-9 [51]; 266-018-8 [52];

What Annex II means for Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2]

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 25637-99-4 [1] 3194-55-6 [2] is the unique numerical identifier assigned to Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2]

This page summarizes one Annex II record for Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Hexabromocyclododecane [1]; 1,2,5,6,9,10-Hexabromocyclododecane [2], but confirm any final regulatory decision against the current official annex wording and source files.

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