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Annex II Entry 1512 CMR30/07/2020

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3]

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1512
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 142-64-3
CAS 142-64-3PubChem CID 8893

Piperazine Dihydrochloride

Piperazine dihydrochloride appears as white to cream-colored needles or powder. Mp: 318-20 °C (with decomposition). — CAMEO Chemicals

IUPAC name
piperazine;dihydrochloride
Molecular formula
C4H12Cl2N2
Molecular weight
159.05 g/mol
Exact mass
158.0377538 Da
Topological polar surface area
24.1 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

Dowzene DHCPiperazine, dihydrochloridePiperazine wormer premixDihydro Pip WormerDiethylenediamine dihydrochlorideAscarex DDihydrochloride salt of diethylenediamine17VU4Z4W88
16 more reported names
Piperazine, hydrochloride (1:2)RefChem:58255205-551-2Piperazine dihydrochloride [USP]Piperazinium chlorideCaswell No. 668HSDB 1182EINECS 205-551-2EPA Pesticide Chemical Code 067401UNII-17VU4Z4W88Piperazinium dichlorideOlaparib Impurity 72 2HClpiperazine-1,4-diium chlorideTox21_302343Piperazine--hydrogen chloride (1/2)GS-5897
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1951-97-9
CAS 1951-97-9PubChem CID 64733

Piperazine, phosphate (1:?)

IUPAC name
phosphoric acid;piperazine
Molecular formula
C4H13N2O4P
Molecular weight
184.13 g/mol
Exact mass
184.06129390 Da
Topological polar surface area
102.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

PinrouPiperazine, phosphateRefChem:863449217-775-8PiperazinephosphatePiperazatePiperazine phosphate anhydrousPiperazine, phosphate (1:1)
16 more reported names
PIPERVERMTASNON (TABL.)P7S1V82385Anthalazine phosphatephosphoric acid; piperazineEINECS 217-775-8Piperazine, compound with phosphoric acidPIPERAZINE MONOPHOSPHATEUNII-P7S1V82385EINECS 238-572-0Piperazine xphosphatepiperazine orthophosphatephosphoric acid,piperazineEC 217-775-8C4H13N2O4PPIPERAZINE PHOSPHATE [MI]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6094-40-2
CAS 6094-40-2PubChem CID 82044

Piperazine, hydrochloride (1:?)

IUPAC name
piperazine;hydrochloride
Molecular formula
C4H11ClN2
Molecular weight
122.60 g/mol
Exact mass
122.0610761 Da
Topological polar surface area
24.1 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
2
Covalent units
2
Defined stereocentres
0

Also known as

PIPERAZINE HYDROCHLORIDERefChem:863447228-042-7Piperazine monohydrochloridePiperazine HCl7542-23-6Piperazinium chloridePiperazine, monohydrochloride
13 more reported names
Piperazine hydrochloride hydrate7N36JHA4P6UNII-7N36JHA4P6Piperazine, hydrochloride (1:1)EINECS 228-042-7EINECS 231-422-5SCHEMBL7690piperazine hydrochloride saltpiperazine hydrochloric acid saltPiperazine--hydrogen chloride (1/1)8006-71-1DB-309178PIPERAZINE MONOHYDROCHLORIDE [GREEN BOOK]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3]

Chemical / IUPAC name

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3]

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
6094-40-2 [1] 142-64-3 [2] 1951-97-9 [3]
EC
228-042-7 [1] 205-551-2 [2] 217-775-8 [3]
Annex
II
Entry number
1512

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3]

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 6094-40-2 [1] 142-64-3 [2] 1951-97-9 [3] is the unique numerical identifier assigned to Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3]

This page summarizes one Annex II record for Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Piperazine hydrochloride [1]; Piperazine dihydrochloride [2]; Piperazine phosphate [3], but confirm any final regulatory decision against the current official annex wording and source files.

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