Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Hydroxylamine sulfate
Hydroxylamine sulfate is a colorless crystalline solid. Contact may cause severe irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. — CAMEO Chemicals
- IUPAC name
- hydroxyazanium;sulfate
- Molecular formula
- H8N2O6S
- Molecular weight
- 164.14 g/mol
- Exact mass
- 164.01030715 Da
- Topological polar surface area
- 184.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 6
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID2025424
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Density: greater than 1 at 68 °F (USCG, 1999) Source: CAMEO Chemicals
- Density: 1.88 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: -3.6 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 338 °F (decomposes) (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 170 °C Source: PAC Chemical Database, U.S. Department of Energy
- Physical Description: Hydroxylamine sulfate is a colorless crystalline solid. Contact may cause severe irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Source: CAMEO Chemicals
- Physical Description: Liquid; Other Solid; Liquid; Dry Powder; Liquid; Large Crystals; Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Solid; [Merck Index] White odorless solid; [CHRIS] Colorless crystals; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: WHITE CRYSTALS OR POWDER. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Solubility in water, g/100ml at 20 °C: 58.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
- ERG2024, Guide 154 (Hydroxylamine sulfate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H290: May be corrosive to metals [Warning Corrosive to Metals]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P234, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P390, P391, P405, P406, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H290 (97.9%): May be corrosive to metals [Warning Corrosive to Metals]; H302+H312 (15.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (98%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351 (97.9%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (98%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (97.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H412 (62%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P234, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P390, P391, P405, P406, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1096 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Consumer Uses: Not Known or Reasonably Ascertainable; Reducing agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Chelating agent; Etching agent; Intermediate; Reducing agent; Not Known or Reasonably Ascertainable; Plating agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a reducing agent in photography, an antioxidant for fatty acids and soaps, and a dehairing agent for hides; [Merck Index] Used mainly as an intermediate for cyclohexanone oxime or caprolactum; Also used as an intermediate (pharmaceuticals, insecticides, herbicides, and artificial sweeteners), photographic developer, vulcanizing accelerator, antioxidant for natural rubber, and inhibitor in plastic polymerizations; Other uses are surface treatment of steel, separation of uranium and plutonium, electroplating of metals and plastics, and fixing textile dyes; [EU Risk Assessment] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Steel Producing [Category: Industry]; Electroplating [Category: Plate]; Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Hydroxyamine hydrochloride
Hydroxylamine hydrochloride is an organic molecular entity. — ChEBI
- IUPAC name
- hydroxylamine;hydrochloride
- Molecular formula
- ClH4NO
- Molecular weight
- 69.49 g/mol
- Exact mass
- 68.9981414 Da
- Topological polar surface area
- 46.3 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 2
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:5807
- ChEMBL:CHEMBL542448
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Chemical / IUPAC name
Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 2 | ✓ | — | — |
Key data
Inventory links for Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Related records for Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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What Annex II means for Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]
This page summarizes one Annex II record for Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Hydroxylammonium chloride; hydroxylamine hydrochloride [1]; Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2], but confirm any final regulatory decision against the current official annex wording and source files.
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