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Annex II Entry 1513 CMR30/07/2020

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1513
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 87691-88-1
CAS 87691-88-1PubChem CID 11521711

3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride

IUPAC name
3-piperazin-1-yl-1,2-benzothiazole;hydrochloride
Molecular formula
C11H14ClN3S
Molecular weight
255.77 g/mol
Exact mass
255.0596963 Da
Topological polar surface area
56.4 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0

Also known as

UNII-OSY1987N5VOSY1987N5V4-(1,2-Benzisothiazol-3-yl)piperazine hydrochloride1,2-Benzisothiazole, 3-(1-piperazinyl)-, hydrochloride (1:1)EC 421-310-6RefChem:92069618-049-73-Piperazinobenzisothiazole hydrochloride
16 more reported names
3-Piperazinyl-1,2-Benzisothiazole Hydrochloride3-(Piperazin-1-yl)benzo[d]isothiazole hydrochloride3-(1-piperazinyl)-1,2-Benzisothiazole hydrochloride3-(Piperazin-1-yl)benzo[d]isothiazole xhydrochloride3-Piperazin-1-yl-benzo[d]isothiazole hydrochloride3-(piperazin-1-yl)-1,2-benzothiazole hydrochlorideC11H14ClN3S3-PIPERAZINOBENZISOTHIAZOLE3-(Piperazin-1-yl)benzo[d]isothiazolexhydrochloride3-piperazin-1-yl-1,2-benzisothiazole hydrochlorideZiprasidone EP Impurity A HCl3-(1-Piperazinyl)-1,2-benzisothiazole HClBITP HCl1,2-Benzisothiazole, 3-(1-piperazinyl)-, hydrochloride1,2-Benzisothiazole, 3-(1-piperazinyl)-, monohydrochloride3-Piperazinyl-1,2-benzisothiazolehydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride

Chemical / IUPAC name

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
87691-88-1
EC
421-310-6
Annex
II
Entry number
1513

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 87691-88-1 is the unique numerical identifier assigned to 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride

This page summarizes one Annex II record for 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 3-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride, but confirm any final regulatory decision against the current official annex wording and source files.

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