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Annex II Entry 1516 CMR30/07/2020

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1516
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 159939-85-2
CAS 159939-85-2PubChem CID 91980975

4-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1,2-benzenediamine dihydrochloride

IUPAC name
4-[(3-chlorophenyl)-imidazol-1-ylmethyl]benzene-1,2-diamine;dihydrochloride
Molecular formula
C16H17Cl3N4
Molecular weight
371.7 g/mol
Exact mass
370.051880 Da
Topological polar surface area
69.9 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
3
Covalent units
3
Defined stereocentres
0

Also known as

4-[(3-CHLOROPHENYL)(1H-IMIDAZOL-1-YL)METHYL]-1,2-BENZENEDIAMINE DIHYDROCHLORIDERefChem:509191EC 425-030-5425-030-5KQJIWUSBJURZNV-UHFFFAOYSA-N4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]benzene-1,2-diamine--hydrogen chloride (1/2)4-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1,2-benzenediamine hydrochloride (1:2)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

Chemical / IUPAC name

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
159939-85-2
EC
425-030-5
Annex
II
Entry number
1516

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 159939-85-2 is the unique numerical identifier assigned to 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

This page summarizes one Annex II record for 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride, but confirm any final regulatory decision against the current official annex wording and source files.

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