EU cosmetic ingredients, restrictions and safety

Annex II Entry 1458 CMR30/07/2020

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1458

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 68610-24-2

CAS 68610-24-2PubChem CID 225469

6,8-Dichloroquinazoline-2,4(1h,3h)-dione

IUPAC name: 6,8-dichloro-1H-quinazoline-2,4-dione

Molecular formula: C8H4Cl2N2O2
Molecular weight: 231.03 g/mol
Exact mass: 229.9649828 Da
XLogP3: 1.7
Topological polar surface area: 58.2 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

610-24-2RefChem:3063146,8-dichloro-1,2,3,4-tetrahydroquinazoline-2,4-dioneNSC-14883BAS 075714016,8-dichloroquinazolin-2,4(1H,3H)-dione6,8-Dichloro-2,4-[1H.3H]-quinazolinedione6,8-Dichloro-2,4(1H,3H)-quinazolinedione #

2 more reported names

SR-01000363695SR-01000363695-1

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID80279974

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900

Chemical / IUPAC name

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900

Regulatory information

Regulation

See every entry this act set

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1A	✓	—	—

Key data

CAS

EC

Annex

Entry number

1458

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1457

Nearby record in the same annex

Nickel diarsenide [1]; Nickel arsenide [2]

CAS: 12068-61-0 [1] / 27016-75-7 [2]

EC: 235-103-1 [1] / 248-169-1 [2]

Annex II 1459

Nearby record in the same annex

Nickel dichlorate [1]; Nickel dibromate [2]; Ethyl hydrogen sulfate, nickel(II) salt [3]

CAS: 67952-43-6 [1] 14550-87-9 [2] 71720-48-4 [3]

EC: 267-897-0 [1] 238-596-1 [2] 275-897-7 [3]

Annex II 1456

Nearby record in the same annex

Silicic acid, lead nickel salt

CAS: 68130-19-8

Annex II 1460

Nearby record in the same annex

Nickel(II) trifluoroacetate; [1] Nickel(II) propionate; [2] Nickel bis(benzenesulfonate); [3] Nicke…

CAS: 16083-14-0 [1] 3349-08-4 [2] 39819-65-3 [3] 18721-51-2 [4] 18283-82-4 [5] 22605-92-1 [6] 4454-16-4 [7] 7580-31-6 [8] 93983-68-7 [9] 29317-63-3 [10] 27637-46-3 [11] 84852-37-9 [12] 93920-10-6 [13] 85508-43-6 [14] 85508-44-7 [15] 51818-56-5 [16] 93920-

EC: 240-235-8 [1] 222-102-6 [2] 254-642-3 [3] 242-533-3 [4] 242-161-1 [5] 245-119-0 [6] 224-699-9 [7] 231-480-1 [8] 301-323-2 [9] 249-555-2 [10] 248-585-3 [11] 284-349-6 [12] 300-094-6 [13] 287-468-1 [14] 287-469-7 [15] 257-447-1 [16] 300-093-0 [17] 276-

Annex II 1455

Nearby record in the same annex

Nickel selenide

CAS: 1314-05-2

EC: 215-216-2

Annex II 1461

Nearby record in the same annex

Nickel(II) sulfite [1]; Nickel tellurium trioxide [2]; Nickel tellurium tetraoxide [3]; Molybdenum …

CAS: 7757-95-1 [1] / 15851-52-2 [2] / 15852-21-8 [3] / 68130-36-9 [4]

EC: 231-827-7 [1] / 239-967-0 [2] / 239-974-9 [3] / 268-585-7 [4]

Annex II 1454

Nearby record in the same annex

Nickel(II) selenite

CAS: 10101-96-9

EC: 233-263-7

Annex II 1462

Nearby record in the same annex

Nickel boride (NiB) [1]; Dinickel boride [2]; Trinickel boride [3]; Nickel boride [4]; Dinickel sil…

CAS: 12007-00-0 [1] / 12007-01-1 [2] / 12007-02-2 [3] / 12619-90-8 [4] / 12059-14-2 [5] / 12201-89-7 [6] / 12035-64-2 [7] / 65229-23-4 [8]

EC: 234-493-0 [1] / 234-494-6 [2] / 234-495-1 [3] / 235-723-2 [4] / 235-033-1 [5] / 235-379-3 [6] / 234-828-0 [7] / - [8]

Annex II 1453

Nearby record in the same annex

Nickel dichromate

CAS: 15586-38-6

EC: 239-646-5

Annex II 1463

Nearby record in the same annex

Dialuminium nickel tetraoxide [1]; Nickel titanium trioxide [2]; Nickel titanium oxide [3]; Nickel …

CAS: 12004-35-2 [1] / 12035-39-1 [2] / 12653-76-8 [3] / 52502-12-2 [4] / 68016-03-5 [5] / 70692-93-2 [6] / 14177-55-0 [7] / 14177-51-6 [8] / 68515-84-4 [9] / 12031-65-1 [10] / 12673-58-4 [11]

EC: 234-454-8 [1] / 234-825-4 [2] / 235-752-0 [3] / 257-970-5 [4] / 268-169-5 [5] / 274-755-1 [6] / 238-034-5 [7] / 238-032-4 [8] / 271-112-7 [9] / - [10] / - [11]

Annex II 1452

Nearby record in the same annex

Nickel dithiocyanate

CAS: 13689-92-4

EC: 237-205-1

Annex II 1464

Nearby record in the same annex

Cobalt lithium nickel oxide

EC: 442-750-5

What Annex II means for Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).
This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 68610-24-2 is the unique numerical identifier assigned to Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex II record Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900

This page summarizes one Annex II record for Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 77900, but confirm any final regulatory decision against the current official annex wording and source files.

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