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Annex II Entry 1426 CMR30/07/2020

Nickel bis(sulfamidate); nickel sulfamate

Nickel bis(sulfamidate); nickel sulfamate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1426
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 13770-89-3
CAS 13770-89-3PubChem CID 83720

Nickel sulfamate

Nickel sulfamate is a chemical compound of nickel. Nickel is a chemical compound with the atomic number 28. It is found abundantly in nature in laterite ore minerals, such as limonite, garnierite, and pentlandite. Nickel has a biological role and is found in certain enzymes, including urease, hydrogenase, methylcoenzyme M reductase, and carbon monoxide dehydrogenase. (L40, L41) — Toxin and Toxin Target Database (T3DB)

IUPAC name
nickel(2+) disulfamate
Molecular formula
H4N2NiO6S2
Molecular weight
250.87 g/mol
Exact mass
249.886420 Da
Topological polar surface area
183.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
8
Covalent units
3
Defined stereocentres
0

Also known as

Sulfamic acid, nickel(2+) salt (2:1)EINECS 237-396-1NSC 78888AI3-18003EC 237-396-1NICKEL SULFAMINATENickel sulfamate (6CI,7CI)Nickel sulphamate
16 more reported names
Nickel sulfamic acidNickel sulphamic acidNickel(2+) sulfamateRefChem:165681(SULFAMOYLOXY)NICKELIO SULFAMATEnickel bis(sulfamidate);nickel sulfamate237-396-1nickel bis(sulphamidate)Nickel(II) sulfamatenickel(2+);disulfamateAeronikl 250Aeronikl 400Aeronikl 575Nickel (II) sulfamateNICKEL BIS(SULFAMIDATE)DB-352578
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel bis(sulfamidate); nickel sulfamate

Chemical / IUPAC name

Nickel bis(sulfamidate); nickel sulfamate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓—✓
Cat. 2—✓—

Key data

CAS
13770-89-3
EC
237-396-1
Annex
II
Entry number
1426

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1421
Nearby record in the same annex

Nickel matte

CAS: 69012-50-6
EC: 273-749-6

What Annex II means for Nickel bis(sulfamidate); nickel sulfamate

Nickel bis(sulfamidate); nickel sulfamate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel bis(sulfamidate); nickel sulfamate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 13770-89-3 is the unique numerical identifier assigned to Nickel bis(sulfamidate); nickel sulfamate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel bis(sulfamidate); nickel sulfamate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nickel bis(sulfamidate); nickel sulfamate

This page summarizes one Annex II record for Nickel bis(sulfamidate); nickel sulfamate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel bis(sulfamidate); nickel sulfamate, but confirm any final regulatory decision against the current official annex wording and source files.

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