EU cosmetic ingredients, restrictions and safety

Annex II Entry 1431 CMR30/07/2020

Nickel bis(4-cyclohexylbutyrate)

Nickel bis(4-cyclohexylbutyrate) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1431

CMR

Record details

Chemical name

Nickel bis(4-cyclohexylbutyrate)

Chemical / IUPAC name

Nickel bis(4-cyclohexylbutyrate)

Regulatory information

Regulation

(EU) 2019/831

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1B	✓	—	✓
Cat. 2	—	✓	—

Key data

CAS

EC

Annex

Entry number

1431

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1430

Nearby record in the same annex

Nickel dibenzoate

CAS: 553-71-9

EC: 209-046-8

Annex II 1432

Nearby record in the same annex

Nickel(II) stearate; nickel(II) octadecanoate

CAS: 2223-95-2

EC: 218-744-1

Annex II 1429

Nearby record in the same annex

Nickel di(acetate) [1]; Nickel acetate [2]

CAS: 373-02-4 [1] 14998-37-9 [2]

EC: 206-761-7 [1] 239-086-1 [2]

Annex II 1433

Nearby record in the same annex

Nickel dilactate

CAS: 16039-61-5

Annex II 1428

Nearby record in the same annex

Nickel diformate [1]; Formic acid, nickel salt [2]; Formic acid, copper nickel salt [3]

CAS: 3349-06-2 [1] 15843-02-4 [2] 68134-59-8 [3]

EC: 222-101-0 [1] 239-946-6 [2] 268-755-0 [3]

Annex II 1434

Nearby record in the same annex

Nickel(II) octanoate

CAS: 4995-91-9

EC: 225-656-7

Annex II 1426

Nearby record in the same annex

Nickel bis(sulfamidate); nickel sulfamate

CAS: 13770-89-3

EC: 237-396-1

Annex II 1435

Nearby record in the same annex

Nickel difluoride [1]; Nickel dibromide [2]; Nickel diiodide [3]; Nickel potassium fluoride [4]

CAS: 10028-18-9 [1] 13462-88-9 [2] 13462-90-3 [3] 11132-10-8 [4]

EC: 233-071-3 [1] 236-665-0 [2] 236-666-6 [3] - [4]

Annex II 1425

Nearby record in the same annex

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

CAS: 13842-46-1 [1] 15699-18-0 [2]

EC: 237-563-9 [1] 239-793-2 [2]

Annex II 1436

Nearby record in the same annex

Nickel hexafluorosilicate

CAS: 26043-11-8

EC: 247-430-7

Annex II 1424

Nearby record in the same annex

Nickel diperchlorate; perchloric acid, nickel(II) salt

CAS: 13637-71-3

EC: 237-124-1

Annex II 1437

Nearby record in the same annex

Nickel selenate

CAS: 15060-62-5

EC: 239-125-2

What Annex II means for Nickel bis(4-cyclohexylbutyrate)

Nickel bis(4-cyclohexylbutyrate) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009. No concentration limit applies — the presence of this substance in any cosmetic product placed on the EU market is not permitted regardless of use level.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).
This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel bis(4-cyclohexylbutyrate) is listed in Annex II of EU Cosmetics Regulation 1223/2009 as a prohibited substance. It must not be present in any cosmetic product placed on the EU market at any concentration.

CAS 3906-55-6 is the unique numerical identifier assigned to Nickel bis(4-cyclohexylbutyrate) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel bis(4-cyclohexylbutyrate) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex II record Nickel bis(4-cyclohexylbutyrate)

This page summarizes one Annex II record for Nickel bis(4-cyclohexylbutyrate) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel bis(4-cyclohexylbutyrate), but confirm any final regulatory decision against the current official annex wording and source files.

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