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Annex II Entry 1425 CMR30/07/2020

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1425
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 13842-46-1
CAS 13842-46-1PubChem CID 25021995

Nickel dipotassium bis(sulphate)

IUPAC name
dipotassium;nickel(2+);disulfate
Molecular formula
K2NiO8S2
Molecular weight
329.02 g/mol
Exact mass
327.766214 Da
Topological polar surface area
177.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Covalent units
5
Defined stereocentres
0

Also known as

EINECS 237-563-9RefChem:853870237-563-9nickel dipotassium disulfatePBOHWEFYZPOHIB-UHFFFAOYSA-JNickel(2+) potassium sulfate (1/2/2)
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 15699-18-0
CAS 15699-18-0PubChem CID 27455

Sulfuric acid, ammonium nickel(2+) salt (2:2:1)

Ammonium nickel sulfate is a nickel coordination entity comprising ammonium, nickel and sulfate in which the ratio of ammonium to iron(2+) to sulfate ions is 2:1:2. It is a nickel coordination entity, an ammonium salt and a metal sulfate. It contains a nickel(2+). — ChEBI

IUPAC name
diazanium;nickel(2+);disulfate
Molecular formula
H8N2NiO8S2
Molecular weight
286.90 g/mol
Exact mass
285.907549 Da
Topological polar surface area
179.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
8
Covalent units
5
Defined stereocentres
0

Also known as

Ammonium nickel sulfateNICKEL AMMONIUM SULFATEAmmonium disulfatonickelate(II)616U208TNXNickel ammonium sulfate (Ni(NH4)2(SO4)2)CHEBI:86151DIAMMONIUM NICKEL DISULFATENiccolum Causticum
14 more reported names
RefChem:853830239-793-5Nickel(II) ammonium sulfateDiammonium nickel bis(sulphate)ammonium nickel(2+) sulfate (2/1/2)HSDB 1241EINECS 239-793-5Nickel ammonium sulfatesUNII-616U208TNXammonium nickel sulfate (anhydrous)nickel ammonium sulfate (anhydrous)NICKEL AMMONIUM SULFATE [MI]NICKEL AMMONIUM SULFATE [HSDB]SULFURIC ACID AMMONIUM NICKEL(2+) SALT (2:2:1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

Chemical / IUPAC name

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓—✓
Cat. 2—✓—

Key data

CAS
13842-46-1 [1] 15699-18-0 [2]
EC
237-563-9 [1] 239-793-2 [2]
Annex
II
Entry number
1425

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1421
Nearby record in the same annex

Nickel matte

CAS: 69012-50-6
EC: 273-749-6

What Annex II means for Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 13842-46-1 [1] 15699-18-0 [2] is the unique numerical identifier assigned to Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]

This page summarizes one Annex II record for Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2], but confirm any final regulatory decision against the current official annex wording and source files.

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