Annex II
Entry 1420
CMR30/07/2020
Nickel dinitrate [1]; Nitric acid, nickel salt [2]
Nickel dinitrate [1]; Nitric acid, nickel salt [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1420
CMR
Chemical identity and properties
CAS 13138-45-9CAS 14216-75-2PubChem CID 25736
Nickel nitrate
Nickel nitrate is a green crystalline solid. It is soluble in water. It is noncombustible, but it will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Toxic oxides of nitrogen are produced in fires involving this material. It is used in nickel plating and to make nickel catalysts for use in chemical manufacture. — CAMEO Chemicals
- IUPAC name
- nickel(2+) dinitrate
- Molecular formula
- N2NiO6
- Molecular weight
- 182.70 g/mol
- Exact mass
- 181.910977 Da
- Topological polar surface area
- 126.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 6
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Nickel(II) nitrateNickel dinitrateNickelous nitrateNickel bis(nitrate)Nickel(2+) nitrateNitric acid, nickel(2+) saltNickel nitrate (Ni(NO3)2)Nickel(II) nitrate (1:2)
16 more reported names
Nitric acid, nickel(II) salt50L0S38I2DNiccolum NitricumRefChem:6059NICKEL(2+) ION DINITRATE236-068-5nickel(2+);dinitrateNitric acid, nickel(2+) salt (2:1)CCRIS 5562HSDB 1829N2NiO6Nitric acid, nickel saltEINECS 236-068-5UN2725UNII-50L0S38I2DNickel Nitrate GFAA Matrix Modifier: 1% Ni(NO3)2 in 2% HNO3
External database identifiers
- EPA DTXSID:DTXSID70872958
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match25736
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 137 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: GREEN CRYSTALS Source: Hazardous Substances Data Bank (HSDB)
- Density: 2.05 at 68 °F (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 2.05 no temp Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: 56.7 °C Source: PAC Chemical Database, U.S. Department of Energy
- Physical Description: Nickel nitrate is a green crystalline solid. It is soluble in water. It is noncombustible, but it will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Toxic oxides of nitrogen are produced in fires involving this material. It is used in nickel plating and to make nickel catalysts for use in chemical manufacture. Source: CAMEO Chemicals
- Physical Description: Liquid; Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Hexahydrate: green, deliquescent crystals with a mp of 56.7 deg C; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Green odorless solid; [CHRIS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: SOL IN 238.5 G/100 CC WATER AT 0 °C /HEXAHYDRATE/ Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOL IN ALCOHOL; AMMONIUM HYDROXIDE /HEXAHYDRATE/ Source: Hazardous Substances Data Bank (HSDB)
- Solubility: VERY SOL IN HOT WATER /HEXAHYDRATE/ Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3 G/100 ML HYDRAZINE AT 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 7.5 WT% IN ETHYLENE GLYCOL AT 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 48.5 WT% IN WATER AT 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Inhalation (L41) ; oral (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- First Aid: INHALATION: move to fresh air; got medical attention if exposure has been severe.; INGESTION: give large amount of water.; EYES: flush with water for at least 15 min.; SKIN: wash with soap and water. (USCG, 1999) Source: CAMEO Chemicals
- ERG2024, Guide 140 (Nickel nitrate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H360D ***: May damage the unborn child [Danger Reproductive toxicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H272 (94.3%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (99.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (99.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (99.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (98.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (99.3%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (90.1%): May cause cancer [Danger Carcinogenicity]; H360 (90.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (99.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (99.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 283 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H272 (100%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P318, P321, P333+P317, P342+P316, P362+P364, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. Nitrat Source: Toxin and Toxin Target Database (T3DB)
- Consumer Uses: Catalyst Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Catalyst; Adhesion/cohesion promoter; Intermediate; Plating agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used in nickel plating and to make brown ceramic pigments; [Merck Index] Used in batteries; [HSDB] Used to make nickel catalysts; [CAMEO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Battery Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Activities with risk of exposure: Ceramics making [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Sources/Uses: Used in nickel plating and ceramics; [EPA OHM/TADS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Electroplating [Category: Plate] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Nickel-plating; mfr of brown ceramic colors Source: Hazardous Substances Data Bank (HSDB)
- Uses: Nickel plating; prepn of nickel catalysts; mfr of brown ceramic colors /Hexahydrate/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: IN BATTERIES Source: Hazardous Substances Data Bank (HSDB)
- Uses: COLORANT FOR GLASS Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for NICKEL NITRATE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Nickel dinitrate [1]; Nitric acid, nickel salt [2]
Chemical / IUPAC name
Nickel dinitrate [1]; Nitric acid, nickel salt [2]
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | ✓ | — | ✓ |
| Cat. 2 | — | ✓ | — |
Key data
Related records for Nickel dinitrate [1]; Nitric acid, nickel salt [2]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Annex II
1422
Nearby record in the same annex
Slimes and sludges, copper electrolytic refining, decopperised, nickel sulfate
CAS: 92129-57-2
EC: 295-859-3
Annex II
1423
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Slimes and sludges, copper electrolyte refining, decopperised
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EC: 305-433-1
Annex II
1424
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Nickel diperchlorate; perchloric acid, nickel(II) salt
CAS: 13637-71-3
EC: 237-124-1
Annex II
1415
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Potassium titanium oxide (K2Ti6O13)
CAS: 12056-51-8
EC: 432-240-0
Annex II
1425
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Nickel dipotassium bis(sulfate) [1]; Diammonium nickel bis(sulfate) [2]
CAS: 13842-46-1 [1] 15699-18-0 [2]
EC: 237-563-9 [1] 239-793-2 [2]
Annex II
1414
Nearby record in the same annex
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EC: 427-050-1
Annex II
1426
Nearby record in the same annex
Nickel bis(sulfamidate); nickel sulfamate
CAS: 13770-89-3
EC: 237-396-1
What Annex II means for Nickel dinitrate [1]; Nitric acid, nickel salt [2]
Nickel dinitrate [1]; Nitric acid, nickel salt [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Yes. Nickel dinitrate [1];
Nitric acid, nickel salt [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 13138-45-9 [1] 14216-75-2 [2] is the unique numerical identifier assigned to Nickel dinitrate [1];
Nitric acid, nickel salt [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
Nickel dinitrate [1];
Nitric acid, nickel salt [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record Nickel dinitrate [1]; Nitric acid, nickel salt [2]
This page summarizes one Annex II record for Nickel dinitrate [1]; Nitric acid, nickel salt [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Nickel dinitrate [1]; Nitric acid, nickel salt [2], but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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