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Annex II Entry 1405 CMR30/07/2020

O-Isobutyl-N-ethoxy carbonylthiocarbamate

O-Isobutyl-N-ethoxy carbonylthiocarbamate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1405
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 103122-66-3
CAS 103122-66-3PubChem CID 3034440

Thioimidodicarbonic acid ((HO)C(O)NHC(S)(OH)), O1-ethyl O3-(2-methylpropyl) ester

IUPAC name
ethyl N-(2-methylpropoxycarbothioyl)carbamate
Molecular formula
C8H15NO3S
Molecular weight
205.28 g/mol
Exact mass
205.07726451 Da
XLogP3
2.4
Topological polar surface area
79.7 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Carbamic acid, ((2-methylpropoxy)thioxomethyl)-, ethyl esterEC 434-350-4Thioimidodicarbonic acid ((HO)C(O)NHC(S)(OH)), 1-ethyl 3-(2-methylpropyl) estero-Isobutyl-N-ethoxy carbonylthiocarbamateCarbamic acid, [(2-methylpropoxy)thioxomethyl]-, ethyl esterRefChem:897817434-350-4XNMRLZYOSGDPRB-UHFFFAOYSA-N
1 more reported name
O-Ethyl O-(2-methylpropyl) 2-imidothiodicarbonate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match3034440

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P318, P319, P321, P330, P333+P317, P362+P364, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P318, P319, P321, P330, P333+P317, P362+P364, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

O-Isobutyl-N-ethoxy carbonylthiocarbamate

Chemical / IUPAC name

O-Isobutyl-N-ethoxy carbonylthiocarbamate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓✓—

Key data

CAS
103122-66-3
EC
434-350-4
Annex
II
Entry number
1405

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for O-Isobutyl-N-ethoxy carbonylthiocarbamate

O-Isobutyl-N-ethoxy carbonylthiocarbamate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. O-Isobutyl-N-ethoxy carbonylthiocarbamate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 103122-66-3 is the unique numerical identifier assigned to O-Isobutyl-N-ethoxy carbonylthiocarbamate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

O-Isobutyl-N-ethoxy carbonylthiocarbamate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record O-Isobutyl-N-ethoxy carbonylthiocarbamate

This page summarizes one Annex II record for O-Isobutyl-N-ethoxy carbonylthiocarbamate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for O-Isobutyl-N-ethoxy carbonylthiocarbamate, but confirm any final regulatory decision against the current official annex wording and source files.

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