Annex II
Entry 1397
15/01/2026
Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1397
Chemical identity and properties
CAS 10332-33-9PubChem CID 23695970
Sodium Perborate Monohydrate
- IUPAC name
- sodium;oxidooxy(oxo)borane;hydrate
- Molecular formula
- BH2NaO4
- Molecular weight
- 99.82 g/mol
- Exact mass
- 99.9943830 Da
- Topological polar surface area
- 50.4 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Caswell No. 784ASodium borate, monohydrateY9UKD0XE6FUNII-Y9UKD0XE6FEPA Pesticide Chemical Code 011105SODIUM BORATE MONOHYDRATESODIUM PERBORATE MONOHYDRATE (MART.)SODIUM PERBORATE MONOHYDRATE [MART.]
11 more reported names
Amosan Wound CleanserRefChem:56246Amosan Oral Wound CleanserAmosan Wound CleanserCherry FlavourPerboric acid, sodium salt, monohydrateSodium perborate monohydrate [USAN]Sodium perborate monohydrate (USAN)Perboric acid sodium salt monohydrateSodium oxoboraneperoxolate--water (1/1/1)SODIUM PERBORATE MONOHYDRATE [WHO-DD]Perboric acid (HBO(O2)), sodium salt, monohydrate
External database identifiers
- EPA DTXSID:DTXSID9035676
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match23695970
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
- ERG2024, Guide 140 (Sodium perborate monohydrate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Note: This chemical does not meet GHS hazard criteria for 2.6% (5 of 192) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H272 (97.4%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302+H332 (19.3%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]; H302 (97.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H318 (97.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331 (20.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (22.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360 (97.4%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 192 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 192 reports by companies.; There are 5 notifications provided by 187 of 192 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P354+P338, P316, P317, P318, P321, P330, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P203, P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P354+P338, P317, P318, P319, P330, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Consumer Uses: Not Known or Reasonably Ascertainable; Oxidizing agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 11138-47-9PubChem CID 23711812
Perboric acid, sodium salt
- IUPAC name
- sodium dihydrogen borate
- Molecular formula
- BH2NaO3
- Molecular weight
- 83.82 g/mol
- Exact mass
- 83.9994684 Da
- Topological polar surface area
- 63.5 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 3
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
sodium;dihydrogen borateEINECS 234-390-0EC 234-390-0NaH2BO3WBQSJYNAUANADO-UHFFFAOYSA-Nboric acid (H3BO3), sodium salt (1:1)
External database identifiers
- EPA DTXSID:DTXSID401360726
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match23711812
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H272 (62.4%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302 (62.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (62.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P354+P338, P317, P318, P319, P330, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 165 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P354+P338, P317, P318, P319, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 121-43-7PubChem CID 8470
Trimethyl borate
Trimethyl borate is a member of the class of borate esters obtained by the formal condensation of three equivalents of methanol with boric acid. — ChEBI
- IUPAC name
- trimethyl borate
- Molecular formula
- C3H9BO3
- Molecular weight
- 103.92 g/mol
- Exact mass
- 104.0644743 Da
- Topological polar surface area
- 27.7 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
TrimethoxyboraneMethyl boratetrimethylborateTrimethoxyboronBoric acid trimethyl esterBorester OBoric acid, trimethyl esterTrimethoxyborine
16 more reported names
Boric acid (H3BO3), trimethyl esterTrimethylester kyseliny boriteNSC-77782U64J6F5NCHEBI:38913RefChem:191751204-468-9934-685-0B(OMe)3B(OCH3)3NSC 777(MeO)3B3349-42-6Trimethyl borate-11BHSDB 5589EINECS 204-468-9
External database identifiers
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8470
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 67.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 68 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 68 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: Colorless, moisture-sensitive liquid; fumes in air Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.915 g/cu cm Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.915 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.92 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: less than 80 °F (NFPA, 2010) Source: CAMEO Chemicals
- Flash Point: < 80 °F (< 27 °C) (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: - 7 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: -1.9 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -29.3 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -29 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -29 °C Source: PAC Chemical Database, U.S. Department of Energy
- Physical Description: Trimethyl borate appears as a water-white liquid. Denser than water. Vapors heavier than air. Used as a solvent and fungicide for fruit. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid; [ICSC] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: COLOURLESS LIQUID. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Refractive Index: Index of refraction: 1.3568 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with tetrahydrofuran, ether, isoporpylamine, hexane, methanol, nujol, and other organic liquids Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with alcohol, ether; soluble in polar nonhydroxylic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water: reaction Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 137.0 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 137 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 25 °C: 18 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 137 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Exposure Routes: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:; Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 129 (Trimethyl borate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P280, P302+P352, P303+P361+P353, P317, P318, P321, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (40.5%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H226 (59.5%): Flammable liquid and vapor [Warning Flammable liquids]; H301 (14.9%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (14.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (85.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H319 (30.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (14.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H360 (11%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (19.3%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H370 (19.8%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P317, P318, P321, P330, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 383 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H312 (97.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264+P265, P280, P302+P352, P303+P361+P353, P305+P351+P338, P317, P321, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H370 (100%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P317, P303+P361+P353, P305+P351+P338, P308+P316, P318, P321, P330, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Bioconcentration is not considered an important environmental fate for trimethyl borate(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl borate, which has a vapor pressure of 136 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(3,4). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Industry Uses: Not Known or Reasonably Ascertainable; Reducing agent; Intermediate Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a flame retardant, welding and brazing flux, chemical intermediate, fungicide, and a solvent for waxes, resins, and oils; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Welding [Category: Weld]; Brazing [Category: Heat or Machine]; Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: As solvent for waxes, resins, oils; catalyst in manufacture of ketones; analysis of paint and varnish ingredients; as neutron detector gas in presence of a scintillation counter; as promoter of diborane reactions Source: Hazardous Substances Data Bank (HSDB)
- Uses: Dehydrating agent; fungicide for citrus fruit Source: Hazardous Substances Data Bank (HSDB)
- Uses: Intermediate in preparation of metal borohydrides Source: Hazardous Substances Data Bank (HSDB)
- Uses: Azeotropic gaseous flux for welding and brazing Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for TRIMETHYL BORATE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 13517-20-9PubChem CID 177839929
Perboric acid (H3BO2(O2)), monosodium salt, trihydrate
- IUPAC name
- sodium;oxidooxyboronic acid;trihydrate
- Molecular formula
- BH8NaO7
- Molecular weight
- 153.86 g/mol
- Exact mass
- 154.0260770 Da
- Topological polar surface area
- 75.8 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 7
- Covalent units
- 5
- Defined stereocentres
- 0
External database identifiers
- EPA DTXSID:DTXSID501346206
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
Chemical / IUPAC name
Sodium perborate [1]; Sodium peroxometaborate; sodium peroxoborate [2]
Regulatory information
SCCS opinions
Identified ingredients
Key data
CAS
13517-20-9 [1], 37244-98-7 [2], 10486-00-7 [3], — [4], 15120-21-5 [5], 7632-04-4/10332-33-9/10486-00-7 [6], 11138-47-9 [7], 12040-72-1 [8], 10332-33-9 [9], 121-43-7 [10]
EC
239-172-9 [1], 234-390-0 [2], — [3], — [4], 239-172-9 [5], 231-556-4 [6], 234-390-0 [7], 234-390-0 [8], — [9], 204-468-9 [10]
Annex
Entry number
1397
Inventory links for Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
Inventory
Restriction reference
Ref 38025
SODIUM PERBORATE
CAS: 15120-21-5 / 7632-04-4 / 11138-47-9
EC: 239-172-9 / 231-556-4 / 234-390-0
Related records for Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Annex II
1396
Nearby record in the same annex
Borates, tetraborates, octaborates and boric acid salts and esters, including: Disodium octaborate …
CAS: 12008-41-2 [1]/ 12280-03-4 [2]/ 10377-81-8 [3]/ 68003-13-4 [4]/ 12712-38-8 [5]/ -[6]/ 1332-07-6 [7]/ 1330-43-4 [8]/ 12267-73-1 [9]/ 13840-56-7 [10]/ 1303-96-4 [11]/ 12179-04-3 [12]
EC: 234-541-0 [1]/ 234-541-0 [2]/ 233-829-3 [3]/ 268-109-8 [4]/ 603-184-6 [5]/ -[6]/ 215-566-6 [7]/ 215-540-4 [8]/ 235-541-3 [9]/ 237-560-2 [10]/ 215-540-4 [11]/ 215-540-4 [12]
Annex II
1400
Nearby record in the same annex
Dibutyltin hydrogen borate
CAS: 75113-37-0
EC: 401-040-5
Annex II
1395
Nearby record in the same annex
Boric acid [1]; Boric acid [2]
CAS: 10043-35-3 [1] 11113-50-1 [2]
EC: 233-139-2 [1] 234-343-4 [2]
Annex II
1401
Nearby record in the same annex
Nickel bis(tetrafluoroborate)
CAS: 14708-14-6
EC: 238-753-4
Annex II
1394
Nearby record in the same annex
Diboron trioxide; boric oxide
CAS: 1303-86-2
EC: 215-125-8
Annex II
1402
Nearby record in the same annex
Mancozeb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt
CAS: 8018-01-7
EC: 616-995-5
Annex II
1393
Nearby record in the same annex
N-Methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
CAS: 872-50-4
EC: 212-828-1
Annex II
1403
Nearby record in the same annex
Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)
CAS: 12427-38-2
EC: 235-654-8
Annex II
1392
Nearby record in the same annex
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CAS: 93107-30-3
EC: 413-760-7
Annex II
1404
Nearby record in the same annex
Benfuracarb (ISO); ethyl N-[2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-…
CAS: 82560-54-1
EC: 617-356-3
What Annex II means for Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Yes. Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1]
Perboric acid, sodium salt, tetrahydrate [2]
Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3]
Sodium peroxoborate, hexahydrate [4]
Sodium perborate [5]
Sodium peroxometaborate; sodium peroxoborate [6]
Perboric acid, sodium salt [7]
Perboric acid, sodium salt, monohydrate [8]
Perboric acid (HBO(O2)), sodium salt, monohydrate [9]
Trimethyl borate [10] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 13517-20-9 [1], 37244-98-7 [2], 10486-00-7 [3], — [4], 15120-21-5 [5], 7632-04-4/10332-33-9/10486-00-7 [6], 11138-47-9 [7], 12040-72-1 [8], 10332-33-9 [9], 121-43-7 [10] is the unique numerical identifier assigned to Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1]
Perboric acid, sodium salt, tetrahydrate [2]
Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3]
Sodium peroxoborate, hexahydrate [4]
Sodium perborate [5]
Sodium peroxometaborate; sodium peroxoborate [6]
Perboric acid, sodium salt [7]
Perboric acid, sodium salt, monohydrate [8]
Perboric acid (HBO(O2)), sodium salt, monohydrate [9]
Trimethyl borate [10] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10]
This page summarizes one Annex II record for Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10], but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
Check your formula
Paste a full INCI list to detect Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10] and other flagged EU annex records in one pass.
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Compare Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O2)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] Sodium perborate [5] Sodium peroxometaborate; sodium peroxoborate [6] Perboric acid, sodium salt [7] Perboric acid, sodium salt, monohydrate [8] Perboric acid (HBO(O2)), sodium salt, monohydrate [9] Trimethyl borate [10] side by side with another annex record to review differences in restrictions, concentrations and annex placement.
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