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Annex II Entry 1406 CMR30/07/2020

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1406
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 101-21-3
CAS 101-21-3PubChem CID 2728

Chlorpropham

Chlorpropham is a carbamate ester that is the isopropyl ester of 3-chlorophenylcarbamic acid. It has a role as a herbicide and a plant growth retardant. It is a member of benzenes, a carbamate ester and a member of monochlorobenzenes. — ChEBI

IUPAC name
propan-2-yl N-(3-chlorophenyl)carbamate
Molecular formula
C10H12ClNO2
Molecular weight
213.66 g/mol
Exact mass
213.0556563 Da
XLogP3
3.5
Topological polar surface area
38.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

CHLOROPROPHAMChloro-IPCCIPCisopropyl (3-chlorophenyl)carbamatePreventolElbanilMetoxonNexoval
16 more reported names
Isopropyl N-(3-chlorophenyl)carbamateChlorprophameTaterpexTriherbicide CIPCMirvalePreventol 56PreweedLiro CIPCKeim-stopStopgerme-SSprout NipChlorIPCIsopropyl m-chlorocarbanilateSpud-NicSpud-NieChloro-IFK
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34630

chlorpropham

A carbamate ester that is the isopropyl ester of 3-chlorophenylcarbamic acid.

Formula
C10H12ClNO2
Average mass
213.664 g/mol
Monoisotopic mass
213.05566 Da
Formal charge
0
  • benzenes — is a (CHEBI:22712)
  • carbamate ester — is a (CHEBI:23003)
  • monochlorobenzenes — is a (CHEBI:83403)
  • herbicide — has role (CHEBI:24527)
  • plant growth retardant — has role (CHEBI:35219)
  • herbicide — has role (CHEBI:24527)
  • plant growth retardant — has role (CHEBI:35219)
  • benzenes — is a (CHEBI:22712)
  • carbamate ester — is a (CHEBI:23003)
  • monochlorobenzenes — is a (CHEBI:83403)
Additional curated names
propan-2-yl (3-chlorophenyl)carbamate1-Methylethyl (3-chlorophenyl)carbamate3-Chlorocarbanilic acid, isopropyl ester(3-Chlorophenyl)carbamic acid, 1-methylethyl esterChloroprophamChlorprophameIsopropyl 3-chlorocarbanilateisopropyl (3-chlorophenyl)carbamateIsopropyl 3-chlorophenylcarbamateIsopropyl m-chlorocarbanilateIsopropyl-m-chlorocarbanilateIsopropyl meta-chlorocarbanilateIsopropyl N-(3-chlorophenyl)carbamateIsopropyl-N-(3-chlorophenyl)carbamateIsopropyl-N-3-chlorophenyl carbamateIsopropyl-N-(3-chlorphenyl)-carbamatIsopropyl N-(m-chlorophenyl)carbamateIsopropyl-N-m-chlorophenyl-carbamatem-Chlorocarbanilic acid isopropyl esterm-Chlorocarbanilic acid, isopropyl esterN-(3-Chlorophenyl)carbamic acid, isopropyl esterN-(3-Chlorophenyl)isopropyl carbamateN-3-ChlorophenylisopropylcarbamateO-Isopropyl N-(3-chlorophenyl)carbamate
Cross-references from this source
  • CAS: 101-21-3 — ChemIDplus
  • CAS: 101-21-3 — KEGG COMPOUND
  • CAS: 101-21-3 — NIST Chemistry WebBook
  • MANUAL_X_REF: 153 — PPDB
  • MANUAL_X_REF: C14506 — KEGG COMPOUND
  • MANUAL_X_REF: Chlorpropham — Wikipedia
  • REGISTRY_NUMBER: 2211397 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-10-24. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match2728

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 1.4% (1 of 71) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H351 (98.6%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (98.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411 (98.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 71 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 71 reports by companies.; There are 9 notifications provided by 70 of 71 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, incre Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Chlorpropham is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 100 was calculated for chlorpropham(SRC), using a log Kow of 3.51(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 245 to 816(2-5), indicates that chlorpropham is expected to have moderate to low mobility in soil(SRC). Volatilization of chlorpropham from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.7X10-7 atm-cu m/mole(SRC),derived from its vapor pressure 1.8X10-4 mm Hg(6) and, water solubility, 89 mg/L(6). Chlorpropham is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 1.8X10-4 mm Hg(6). The leaching of chlorpropham from three types of soil was low and more than 90% of chlorpropham was found in the upper inch of the soil after 4 cm of rain(7). Depending on the nature of soil and climatic conditions, the field half-lives of chlorpropham in soil range from less than 30 days to 65 days(8) with an average half-life of 30 days(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 245 to 816(2-5), indicate that chlorpropham is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(6) based upon an estimated Henry's Law constant of 5.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 1.8X10-4 mm Hg(7), and water solubility, 89 mg/L(7). According to a classification scheme(8), an estimated BCF of 100(SRC), from its log Kow of 3.51(9) and a regression-derived equation(10), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Chlorpropham was found to not hydrolyze in aqueous buffer solution at pH 4, 7, and 9(11). Based on a mean rate constant of 2.6X10-14 L/organism-hr and a bacterial concn of 5X10+8 organisms/L in water, the half-life of chlorpropham has been estimated to be 2208 days(12). Therefore, biodegradation of chlorpropham should not be important in clear bodies of water(SRC). However, biodegradation may become important if the bacterial population in water is several orders of magnitude higher than 10+8 organisms(13). The estimated minimum half-life for the direct sunlight photolysis of Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chlorpropham, which has a vapor pressure of 1.8X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase chlorpropham is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9.7 hours (SRC), calculated from its rate constant of 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Chlorpropham does not absorb light with wavelengths >290 nm(4), and is therefore not expected to be susceptible to direct photolysis by sunlight. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: MOIST SOIL TREATED WITH CHLORPROPHAM TO GIVE CONCN OF 100 PPM AI WAS INCUBATED IN POLYETHYLENE BAGS @ 23 °C FOR 30 WK. CO2 EVOLUTION WAS DETERMINED WEEKLY. CHLORPROPHAM WAS DEGRADED RAPIDLY IN FIRST 6WK & 5% OF ORIGINAL AMT COULD BE DETECTED 30 WK LATER. Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a herbicide to control many annual grassy and broadleaf weeds in alfalfa, lima and snap beans, blueberries, cane berries, cranberries, carrots, ladino clover, garlic, seed grass, peas, onions, spinach, sugar beets, tomatoes, safflower, soybeans, gladioli, and woody nursery stock; Also used to inhibit potato sprouting and for systemic sucker control in tobacco; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For chloropropham (USEPA/OPP Pesticide Code: 018301) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chlorpropham acts as highly selective preemergence and early postemergence herbicide; it effectively controls many annual grassy and broadleaf weeds; application during late fall and winter for control of some perennial weeds. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For control of weeds in alfalfa, lima and snap beans, blueberries, cane berries, cranberries, carrots, ladino clover, garlic, seed grass, peas, onions, spinach, sugar beets, tomatoes, safflower, soybeans, gladioli, woody nursery stock. Also for inhibiting potato sprouting and systemic sucker control in tobacco. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chlorpropham is widely used as an insecticide or pesticide in homes, gardens and agricultural applications. It is a synthetic compound. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

Chemical / IUPAC name

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
101-21-3
EC
202-925-7
Annex
II
Entry number
1406

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Chlorpropham (ISO); isopropyl 3-chlorocarbanilate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 101-21-3 is the unique numerical identifier assigned to Chlorpropham (ISO); isopropyl 3-chlorocarbanilate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

This page summarizes one Annex II record for Chlorpropham (ISO); isopropyl 3-chlorocarbanilate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Chlorpropham (ISO); isopropyl 3-chlorocarbanilate, but confirm any final regulatory decision against the current official annex wording and source files.

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