What is CAS 12427-38-2 for Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)?

CAS 12427-38-2 is the unique numerical identifier assigned to Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 1403 CMR30/07/2020

Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)

Q: Is Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) banned in EU cosmetics?

Yes. Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

Q: How do I check if my product formula contains Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1403

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 12427-38-2

CAS 12427-38-2PubChem CID 3032581

Maneb

Maneb is a yellow powder or crystalline solid. It is denser than water. Contact may irritate skin, eyes and mucous membranes. It may be toxic by ingestion. Likely to generate heat spontaneously upon exposure to air or water. May be sufficient to ignite the material. Maneb is used as a fungicide. Formulations of Maneb include mixing it with many other chemicals such as sulfur, zinc oxide and others to desensitize it. This is done to make it easer for application. — CAMEO Chemicals

IUPAC name: manganese(2+);N-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate

Molecular formula: C4H6MnN2S4
Molecular weight: 265.3 g/mol
Exact mass: 264.879426 Da
Topological polar surface area: 90.2 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

ManebganTrimangolManeb 80Manzate1,2-Ethylenediylbis(carbamodithioato)manganeseManganese, ((1,2-ethanediylbis(carbamodithioato))(2-))-Ethylenebis(dithiocarbamic acid) manganous saltK221E12G7T

16 more reported names

FarmanebManesanRhodianebeSopranebeTubothaneManebaNesporManexNerebAAmanganAgrox flowableGriffin manexUnicrop manebChem nebChloroble MCurzate M

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

PubMed:36842454
PubMed:36117858
PubMed:34897981
PubMed:34830855
PubMed:34052309
PubMed:33368748
PubMed:32553615
PubMed:32375810
PubMed:32194361
PubMed:32169474
PubMed:30797899
PubMed:30740124

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match3032581

Attributed physical-property, hazard, environmental and use annotations.

Color/Form: Yellow powder; crystals from alcohol Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Brown powder Source: Hazardous Substances Data Bank (HSDB)

Density: 1.92 at 25 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
Density: 1.92 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 200 °C (decomposes) Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 392 °F Source: Occupational Safety and Health Administration (OSHA)

Odor: Practically odorless Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Maneb is a yellow powder or crystalline solid. It is denser than water. Contact may irritate skin, eyes and mucous membranes. It may be toxic by ingestion. Likely to generate heat spontaneously upon exposure to air or water. May be sufficient to ignite the material. Maneb is used as a fungicide. Formulations of Maneb include mixing it with many other chemicals such as sulfur, zinc oxide and others to desensitize it. This is done to make it easer for application. Source: CAMEO Chemicals
Physical Description: Yellow or brown powder; crystals from alcohol; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: YELLOW POWDER OR CRYSTALS. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: Yellow powder or crystalline solid. Source: Occupational Safety and Health Administration (OSHA)

Solubility: For more Solubility (Complete) data for Maneb (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Solubility: Soluble in chloroform, pyridine Source: Hazardous Substances Data Bank (HSDB)
Solubility: Practically insoluble in common organic solvents. Soluble in chelating agents (e.g. sodium salts of ethylenediaminetetraacetic acid) with the formation of complexes. Source: Hazardous Substances Data Bank (HSDB)
Solubility: In water, 6.0 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water: very poor Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Vapor Pressure: 0.00000008 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: Vapor pressure: Negligible at 20 °C Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: 7.5X10-8 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: 7.5x10-8 mmHg Source: Occupational Safety and Health Administration (OSHA)

IARC Carcinogenic Agent: Maneb Source: International Agency for Research on Cancer (IARC)
IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
IARC Monographs: Volume 12: (1976) Some Carbamates, Thiocarbamates and Carbazides; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification: 3, not classifiable as to its carcinogenicity to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

First Aid: Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:; Refer to the "General First Aid" section. (ERG, 2024) Source: CAMEO Chemicals
ERG2024, Guide 135 (Maneb, stabilized; Maneb): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
ERG2024, Guide 135 (Maneb; Maneb, stabilized): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H361d ***: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P261, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (96.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (96.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H361 (61.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361d (34.5%): Suspected of damaging the unborn child [Warning Reproductive toxicity]; H400 (96.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (96.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P261, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 84 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H252: Self-heating in large quantities; may catch fire [Warning Self-heating substances and mixtures]; H261: In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P203, P231+P232, P235, P260, P261, P264, P264+P265, P270, P272, P273, P280, P302+P352, P305+P351+P338, P318, P319, P321, P333+P317, P337+P317, P362+P364, P370+P378, P391, P402+P404, P405, P407, P410, P413, P420, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H252: Self-heating in large quantities; may catch fire [Warning Self-heating substances and mixtures]; H261: In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P231+P232, P235, P260, P261, P264+P265, P272, P280, P302+P352, P304+P317, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P402+P404, P407, P410, P413, P420, and P501 (click each P-code to see the statement) Source: NITE-CMC

Target Organs: Endocrine Source: EPA Integrated Risk Information System (IRIS)

Environmental Bioconcentration: In a 3-day static system study, a BCF for maneb of <10 was measured in golden ide (Leuciscus idus melanotus) fish(1). According to a classification scheme(2), this BCF suggests bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 240(2) indicates that maneb is expected to have moderate mobility in soil(SRC). Volatilization from moist soil surfaces is not expected to be an important fate process based upon rapid degradation of maneb in the environment by hydrolysis, oxidation, and photolysis, although microbial degradation may also contribute to soil transformation(3). Maneb is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.5X10-8 mm Hg(2). Aqueous solutions of maneb absorb UV light in the spectrum between 290 and 360 nm(4) which indicates a potential for direct photolysis from moist soil and plant surfaces(SRC). In a 5-day CO2 evolution study using an activated sludge inoculum, 0.6% of applied maneb was detected as 14C-labeled CO2(4), suggesting biodegradation may occur in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 240(2) indicates that maneb is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected based upon rapid degradation of maneb in the environment by hydrolysis, oxidation, and photolysis, although microbial degradation may also contribute to soil transformation(3). According to a classification scheme(4), a BCF of <10, measured in golden ide (Leuciscus idus melanotus) fish(5), suggests bioconcentration in aquatic organisms is low(SRC). Hydrolytic decomposition depends upon the aeration of the water and the pH with faster decomposition in aerated water and with increasing acidity(6). Aqueous solutions of maneb absorb UV light in the spectrum between 290 and 360 nm(5) which indicates a potential for direct photolysis in sunlit water(SRC). 14C-maneb was degraded 9.73-16.18% after 67 days in July and 11.18-27.37% in Sept in sediment at 5 sites from a Nicaraguan estuary incubated under anaerobic conditions(7). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), maneb, which has a vapor pressure of 7.5X10-8 mm Hg at 20 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase maneb may be removed from the air by wet or dry deposition(SRC). Aqueous solutions of maneb absorb UV light in the spectrum between 290 and 360 nm(3) and this indicates a potential for direct photolysis in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)

Sources/Uses: Used to control potato and tomato blights; [EXTOXNET] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For maneb (USEPA/OPP Pesticide Code: 014505) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Fungicide for vegetables, for seed treatment of vegetables and field crops, for deciduous fruits and nuts. Source: Hazardous Substances Data Bank (HSDB)
Uses: Maneb is used on a wide variety of food/feed crops, including fruit and nut crops, vegetable crops, field and forage crops, grapes, field crop seeds, and others; ornamental plants in nurseries and greenhouses; and sod farms. There are no residential uses, and no agricultural uses that could result in exposure to maneb in residential settings. Source: Hazardous Substances Data Bank (HSDB)
Uses: Controls many fungal diseases ... in field crops, fruits, nuts, vegetables, ornaments, turf, etc. Particularly used to control early and late blight of potatoes and tomatoes... Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for Maneb (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Uses: This is a man-made compound that is used as a pesticide. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)

Chemical / IUPAC name

Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 2	—	—	✓

Key data

CAS

12427-38-2

235-654-8

Annex

Entry number

1403

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1402