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Annex II Entry 137 20/10/2010

Piprocurarium iodide (INN)

Piprocurarium iodide (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 137

Chemical identity and properties

PubChem 2D chemical structure for CAS 3562-55-8
CAS 3562-55-8PubChem CID 24418

Piprocurarium Iodide

IUPAC name
diethyl-methyl-[2-[2-[2-(1-methylpiperidin-1-ium-1-yl)-2-phenylacetyl]oxyethoxy]ethyl]azanium diiodide
Molecular formula
C23H40I2N2O3
Molecular weight
646.4 g/mol
Exact mass
646.11284 Da
Topological polar surface area
35.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

BrevicurarineIoduro de piprocurarioIodure de piprocurariumPiprocurarii iodidumLD 2480KJZ34B234TLD-2480piprocurarium (cation)
16 more reported names
RefChem:1096351222-627-0Piprocurarium iodide [INN]diethyl-methyl-[2-[2-[2-(1-methylpiperidin-1-ium-1-yl)-2-phenylacetyl]oxyethoxy]ethyl]azanium;diiodidePiprocurarii iodidum [INN-Latin]EINECS 222-627-0Iodure de piprocurarium [INN-French]Ioduro de piprocurario [INN-Spanish]UNII-KJZ34B234TL.D. 2480RFWPUUOBQMRONB-UHFFFAOYSA-L1-alpha-Carboxybenzyl-1-methylpiperidinium iodide diethyl(2-(2-hydroxyethoxy)ethyl)methylammonium iodide ester7732-96-9Piperidinium, 1-alpha-carboxybenzyl-1-methyl-, iodide, ester with diethyl(2-(2-hydroxyethoxy)ethyl)methylammonium iodide1-(.ALPHA.-CARBOXYBENZYL)-1-METHYLPIPERIDINIUM IODIDE, ESTER WITH DIETHYL(2-(2-HYDROXYETHOXY)ETHYL)METHYLAMMONIUM IODIDE1-.ALPHA.-CARBOXYBENZYL-1-METHYLPIPERIDINIUM IODIDE DIETHYL(2-(2-HYDROXYETHOXY)ETHYL)METHYLAMMONIUM IODIDE ESTER
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Piprocurarium iodide (INN)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
3562-55-8
EC
222-627-0
Annex
II
Entry number
137

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 142
Nearby record in the same annex

Dimethylamine

CAS: 124-40-3
EC: 204-697-4

What Annex II means for Piprocurarium iodide (INN)

Piprocurarium iodide (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Piprocurarium iodide (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 3562-55-8 is the unique numerical identifier assigned to Piprocurarium iodide (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Piprocurarium iodide (INN)

This page summarizes one Annex II record for Piprocurarium iodide (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Piprocurarium iodide (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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