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Annex II Entry 131 20/10/2010

O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO)

O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 131

Chemical identity and properties

PubChem 2D chemical structure for CAS 56-38-2
CAS 56-38-2PubChem CID 991

Parathion

Parathion is an organothiophosphate insecticide, a C-nitro compound and an organic thiophosphate. It has a role as an acaricide, an agrochemical, an avicide, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a mouse metabolite. It is functionally related to a 4-nitrophenol. — ChEBI

IUPAC name
diethoxy-(4-nitrophenoxy)-sulfanylidene-lambda5-phosphane
Molecular formula
C10H14NO5PS
Molecular weight
291.26 g/mol
Exact mass
291.03303072 Da
XLogP3
3.8
Topological polar surface area
106.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

ethyl parathionParathion-ethylThiophosalkronParaphosdanthionphosphostigminestathion
16 more reported names
AphamiteFosfernoRhodiatoxAlleronEtilonFolidolParawetPhoskilNirancorothioncorthionefosfivefosovagearphosgenithionkolphos
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO)

Chemical / IUPAC name

O,O-Diethyl O-4-nitrophenyl phosphorothioate

Regulatory information

Regulation

(EC) 2009/1223

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Key data

CAS
56-38-2
EC
200-271-7
Annex
II
Entry number
131

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO)

O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 56-38-2 is the unique numerical identifier assigned to O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO)

This page summarizes one Annex II record for O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for O,O'-Diethyl-O-4-nitrophenyl phosphorothioate (Parathion - ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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