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Annex II Entry 142 15/10/2010

Dimethylamine

Dimethylamine is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 142

Chemical identity and properties

PubChem 2D chemical structure for CAS 124-40-3
CAS 124-40-3PubChem CID 674

Dimethylamine

Dimethylamine is a secondary aliphatic amine where both N-substituents are methyl. It has a role as a metabolite. It is a member of methylamines and a secondary aliphatic amine. It is a conjugate base of a dimethylaminium. — ChEBI

IUPAC name
N-methylmethanamine
Molecular formula
C2H7N
Molecular weight
45.08 g/mol
Exact mass
45.057849228 Da
XLogP3
-0.2
Topological polar surface area
12.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

N,N-DimethylamineMethanamine, N-methyl-Dimethylamine (anhydrous)RCRA waste number U092Ai3-15638-XARQ8157E0QDimethylamine, anhydrousNSC-8650
16 more reported names
CHEBI:17170methanamine, N-methylRefChem:5765204-697-4Dimethylamine anhydrousDIMETHYLAMINE-N-D1(CH3)2NHDimethylamine aqNSC 8650HNMe2Me2NHDimethylamine (40% aq.)Dimethylamine (~2.0 M in THF)Dimethylamine, 40% aqueous solutiondimethyl amine917-72-6
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External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match674

Attributed physical-property, hazard, environmental and use annotations.

  • Physical Description: Dimethylamine, anhydrous appears as a colorless gas smelling of fish at low concentrations and of ammonia at higher concentrations. Shipped as a liquid under its vapor pressure. Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. The gas, which is corrosive, dissolves readily in water to form flammable corrosive solutions. The gas is heavier than air and can asphyxiate by the displacement of air. Gas is easily ignited and produces toxic oxides of nitrogen when burned. Long-term inhalation of low concentrations or short-term inhalation of low concentrations has adverse health effects. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket. Used to make other chemicals and as a solvent. Source: CAMEO Chemicals
  • Physical Description: Dimethylamine, aqueous solution appears as a solution of a gas in water. Odor ranging from a fishlike to ammonia-like depending on vapor concentration. Corrosive to skin and eyes. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Source: CAMEO Chemicals
  • Physical Description: Gas Vapor; Liquid; Liquid Source: EPA Chemical Data Reporting (CDR)
  • Physical Description: Colorless gas with an ammonia- or fish-like odor; Note: A liquid below 44 degrees F. Shipped as a liquefied compressed gas; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Physical Description: Liquid Source: Human Metabolome Database (HMDB)
  • Physical Description: COLOURLESS COMPRESSED LIQUEFIED GAS WITH PUNGENT ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
  • Physical Description: SOLUTION IN WATER WITH PUNGENT ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
  • Physical Description: Colorless gas with an ammonia- or fish-like odor. Source: Occupational Safety and Health Administration (OSHA)
  • Physical Description: Colorless gas with an ammonia- or fish-like odor. [Note: A liquid below 44 °F. Shipped as a liquefied compressed gas.] Source: The National Institute for Occupational Safety and Health (NIOSH)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a ho Source: CAMEO Chemicals
  • First Aid: Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:; Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024) Source: CAMEO Chemicals
  • ERG2024, Guide 132 (Dimethylamine, aqueous solution; Dimethylamine, solution): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • ERG2024, Guide 118 (Dimethylamine, anhydrous): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately (liquid)/Frostbite; Skin: Water flush immediately (liquid)/Frostbite; Breathing: Respiratory support Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H220: Extremely flammable gas [Danger Flammable gases]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P222, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P377, P381, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H224: Extremely flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H220 (65.5%): Extremely flammable gas [Danger Flammable gases]; H224 (47.3%): Extremely flammable liquid and vapor [Danger Flammable liquids]; H280 (30.1%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H302 (47.1%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (47.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (66.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (88.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (99.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (92.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H411 (12.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]; H412 (33.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P222, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P362+P364, P363, P370+P378, P377, P381, P391, P403, P403+P233, P403+P235, P405, P410+P403, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3043 reports by companies from 43 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H220: Extremely flammable gas [Danger Flammable gases]; H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P222, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P333+P317, P362+P364, P363, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Dimethylamine (DMA) is a colorless gas. It is used as acid-gas absorbent, solvent antioxidants, manufacture of dimethylformamide and dimethylacetamide, dyes, flotation agent, gasoline stabilizers, pharmaceuticals, textile chemicals, rubber accelerators, electroplating, dehairing agent, missile fuels, pesticide propellant, rocket propellants, surfactants, reagent for magnesium. HUMAN STUDIES: Workers in a foundry complaining of breathlessness and choking were found to be exposed to 1-46 mg/cu m DMA in the air. Vision has become misty and halos have appeared several hours after workmen have been exposed to the vapors of DMA at concentration too low to cause discomfort or disability during several hours of exposure. The edema of the corneal epithelium, which is principally responsible for the disturbance of vision, clears spontaneously by the next day, but after exceptionally intense exposures the edema and blurring have taken several days to clear and have been accompanied by photophobia and discomfort from roughness of the corneal surface. ANIMAL STUDIES: A 6% solution of DMA, when applied to the skin of rabbits, caused reddening, then thickening and ulcerati Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Uremic toxins such as dimethylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for dimethylamine(SRC), using a log Kow of -0.38(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a mean Koc value of 434.9 measured in 5 soils(2), indicates that dimethylamine is expected to have moderate mobility in soil(SRC). The pKa of dimethylamine is 10.73(3), indicating that this compound will exist almost entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the cation from moist soil is not expected because cations do not volatilize(SRC). Dimethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1520 mm Hg at 25 °C(5). Dimethylamine was biodegraded 69-89% in three Saskatchewan soils during a 7 day incubation period(6), suggesting that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a measured Koc value of 508 in lake sediment(2), indicates that dimethylamine is expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.73(3) indicates dimethylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Dimethylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -0.38(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Dimethylamine is expected to biodegrade in water based on a half-life of 1.6 days in Vistula River water (Warsaw, Poland) following a 0.3 day lag period(8). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dimethylamine, which has a vapor pressure of 1520 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase dimethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.54X10-11 cu cm/molecule-sec at 25 °C(3). Dimethylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Binder; Not Known or Reasonably Ascertainable; Soil amendments (fertilizers); pH regulating agent; Intermediate Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as an accelerator in the manufacturing of rubber, detergents, and pesticides; Used in leather tanning; Urinary excretion in humans increased after eating certain fish, meat, dairy, and grains containing DMA; [ACGIH] Used in electroplating, epoxy resin curing, textile manufacturing, photographic processing, hide dehairing, and pharmaceutical production; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Plastic Composites Manufacturing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: It is used ... for the production of the solvents dimethylformamide (DMF) and dimethylacetamide (DMAC), for water-treating agents, surfactants, rubber-processing compounds, and a range of agrochemicals. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: As accelerator in vulcanizing rubber, tanning, manufacturing detergent soaps, or attracting boll weevils to exterminate them /former use/. As reagent for magnesium. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Acid-gas absorbent, solvent antioxidants, manufacture of dimethylformamide and dimethylacetamide, dyes, flotation agent, gasoline stabilizers, pharmaceuticals, textile chemicals, rubber accelerators, electroplating, dehairing agent, missile fuels, pesticide propellant, rocket propellants, surfactants, reagent for magnesium. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use as an antiknock agent in fuels. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chemical intermediate in pesticide production, solvents, surfactants, rubber processing, and epoxy resin accelerators. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Naturally produced by the body (endogenous). Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
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NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Dimethylamine

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
124-40-3
EC
204-697-4
Annex
II
Entry number
142

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Dimethylamine

Dimethylamine is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Dimethylamine is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 124-40-3 is the unique numerical identifier assigned to Dimethylamine by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Dimethylamine

This page summarizes one Annex II record for Dimethylamine from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Dimethylamine, but confirm any final regulatory decision against the current official annex wording and source files.

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