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Annex II Entry 1358 08/05/2013

1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products

1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1358

Chemical identity and properties

PubChem 2D chemical structure for CAS 8003-22-3
CAS 8003-22-3PubChem CID 6731

Quinoline Yellow

Quinoline yellow is a quinoline derivative with a 1,3-dioxoindan-2-yl substituent at C-2. It has a role as a dye. It is a member of quinolines, a beta-diketone and an aromatic ketone. — ChEBI

IUPAC name
2-quinolin-2-ylindene-1,3-dione
Molecular formula
C18H11NO2
Molecular weight
273.3 g/mol
Exact mass
273.078978594 Da
XLogP3
3.4
Topological polar surface area
47.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2-(quinolin-2-yl)-1H-indene-1,3(2H)-dioneCHEBI:53700D&C Yellow No 10RefChem:581451D.C. Yellow No. 10Colour Index No. 47005QuinophthaloneSolvent yellow 33
16 more reported names
83-08-911641 YellowQuinoline Yellow 2SFErio Chinoline Yellow 4G2-(2-Quinolyl)-1,3-indandioneD&C Yellow No. 112-(2-Quinolyl)-1,3-indanedione2-(2-Quinolyl)-1H-indene-1,3(2H)-dioneC.I. SOLVENT YELLOW 33D & C Yellow 11NSC 189501H-Indene-1,3(2H)-dione, 2-(2-quinolinyl)-D&C Yellow No 11EINECS 201-453-9Quinoline Yellow SSYellow 11
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

Identified ingredients

Key data

CAS
8003-22-3
EC
232-318-2
Annex
II
Entry number
1358

Inventory links for 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products

Inventory Restriction reference
Ref 32775

CI 47000

CAS: 8003-22-3
EC: 232-318-2
Inventory Shared CAS number
Ref 84552

YELLOW 11

CAS: 83-08-9 / 8003-22-3
EC: 201-453-9 / 232-318-2

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products

1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 8003-22-3 is the unique numerical identifier assigned to 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products

This page summarizes one Annex II record for 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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