Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 1337 07/05/2013

2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products

2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1337

Chemical identity and properties

PubChem 2D chemical structure for CAS 12227-78-0
CAS 12227-78-0PubChem CID 67042721

Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, aluminum salt (3:2)

Molecular formula
C20H8AlI4O5
Molecular weight
862.9 g/mol
Exact mass
862.6366 Da
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
2
Defined stereocentres
0

Also known as

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, aluminum salt (3:2)RefChem:184799C20H8AlI4O5
Open full PubChem recordPubChem annotations3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match67042721

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 92.7% (76 of 82) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 76 of 82 companies (only 7.3% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 82 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 76 of 82 reports by companies.; There is 1 notification provided by 6 of 82 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 15905-32-5
CAS 15905-32-5CAS 16423-68-0PubChem CID 3259

Erythrosine

IUPAC name
3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H8I4O5
Molecular weight
835.9 g/mol
Exact mass
835.6551 Da
XLogP3
6.0
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

E127FD & C red no. 33',6'-dihydroxy-2',4',5',7'-tetraiodospiro(2-benzofuran-3,9'-xanthene)-1-oneFDC Red No. 3RefChem:591122Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium saltErythrosine, sodium anhydrousNSC-36685
16 more reported names
Erythrosin BTetraiodofluoresceinSolvent Red 140IodeosinErythrosine acidErythrosine, phenolic2',4',5',7'-Tetraiodofluorescein2,4,5,7-ErythrosinC.I. Solvent Red 140Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-Erythrosine B (free acid)1A878FZQ9BNSC-328781Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-C.I. Food Red 14FD and C Red No. 3
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

Identified ingredients

Key data

CAS
15905-32-5 -- 16423-68-0 -- 12227-78-0
EC
240-046-0 -- 240-474-8 -- 235-440-4
Annex
II
Entry number
1337

Inventory links for 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products

Inventory Restriction reference
Ref 31629

ACID RED 51

CAS: 16423-68-0; 1342-25-2
EC: 240-474-8
Inventory Restriction reference
Ref 32774

CI 45430

CAS: 16423-68-0 / 12227-78-0
EC: 240-474-8 / 235-440-4

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex IV 80
Shared CAS number

CI 45430

CAS: 12227-78-0
EC: 240-474-8

What Annex II means for 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products

2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 15905-32-5 -- 16423-68-0 -- 12227-78-0 is the unique numerical identifier assigned to 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products

This page summarizes one Annex II record for 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare 2',4',5',7'-Tetraiodofluorescein, its disodium salt (Acid Red 51; CI 45430) and its aluminium salt (Pigment Red 172 Aluminium lake) when used as a substance in hair dye products side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II