Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 127 20/10/2010

Lysergide (INN) (LSD) and its salts

Lysergide (INN) (LSD) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 127

Chemical identity and properties

PubChem 2D chemical structure for CAS 50-37-3
CAS 50-37-3PubChem CID 5761

(+)-Lysergic acid diethylamide

Lysergic acid diethylamide is an ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine. It has a role as a hallucinogen, a serotonergic agonist and a dopamine agonist. It is a monocarboxylic acid amide, an organic heterotetracyclic compound and an ergoline alkaloid. It is functionally related to a lysergamide. — ChEBI

IUPAC name
(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular formula
C20H25N3O
Molecular weight
323.4 g/mol
Exact mass
323.199762429 Da
XLogP3
3.0
Topological polar surface area
39.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
2

Also known as

LysergideLYSERGIC ACID DIETHYLAMIDED-LsdN,N-DiethyllysergamideLysergsaeurediaethylamidN,N-Diethyl-D-lysergamideLysergaure diethylamidLSD-25
16 more reported names
LSD 25LisergideLysergidumN,N-Diethyl-(+)-LysergamideDextrolysergic Acid diethylamidelisergida8NA5SWF92O(+)-LysergideDiethylamid kyseliny lysergoveCHEBI:6605Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)-(8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo(4,3-fg)quinoline-9-carboxamideRefChem:5968
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Lysergide (INN) (LSD) and its salts

Chemical / IUPAC name

9,10-didehydro-N,N-diethyl-6-methylergoline-8beta-carboxamide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
50-37-3
EC
200-033-2
Annex
II
Entry number
127

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Lysergide (INN) (LSD) and its salts

Lysergide (INN) (LSD) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Lysergide (INN) (LSD) and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 50-37-3 is the unique numerical identifier assigned to Lysergide (INN) (LSD) and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record Lysergide (INN) (LSD) and its salts

This page summarizes one Annex II record for Lysergide (INN) (LSD) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Lysergide (INN) (LSD) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Lysergide (INN) (LSD) and its salts and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Lysergide (INN) (LSD) and its salts side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II