Why does CAS 50-37-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 50-37-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 50-37-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 50-37-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 50-37-3

Q: How do I use CAS 50-37-3 for compliance screening?

Cross-reference CAS 50-37-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 50-37-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 50-37-3

CAS 50-37-3PubChem CID 5761

(+)-Lysergic acid diethylamide

Lysergic acid diethylamide is an ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine. It has a role as a hallucinogen, a serotonergic agonist and a dopamine agonist. It is a monocarboxylic acid amide, an organic heterotetracyclic compound and an ergoline alkaloid. It is functionally related to a lysergamide. — ChEBI

IUPAC name: (6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Molecular formula: C20H25N3O
Molecular weight: 323.4 g/mol
Exact mass: 323.199762429 Da
XLogP3: 3.0
Topological polar surface area: 39.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 2

Also known as

LysergideLYSERGIC ACID DIETHYLAMIDED-LsdN,N-DiethyllysergamideLysergsaeurediaethylamidN,N-Diethyl-D-lysergamideLysergaure diethylamidLSD-25

16 more reported names

LSD 25LisergideLysergidumN,N-Diethyl-(+)-LysergamideDextrolysergic Acid diethylamidelisergida8NA5SWF92O(+)-LysergideDiethylamid kyseliny lysergoveCHEBI:6605Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)-(8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo(4,3-fg)quinoline-9-carboxamideRefChem:5968

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:6605
ChEMBL:CHEMBL263881
EPA DTXSID:DTXSID1023231
PubMed:28129538
PubMed:23519215
PubMed:22986365
PubMed:22884772
PubMed:22696164
PubMed:22695498
PubMed:22545225
PubMed:22532793
PubMed:22529655
PubMed:22525626
PubMed:22511703
PubMed:22505971

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 50-37-3

1 total

Annex

Entry

127

Lysergide (INN) (LSD) and its salts

200-033-2

How CAS 50-37-3 is used on this site

CAS 50-37-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 50-37-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 50-37-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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