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Annex II Entry 1195 CMR24/11/2016

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2]

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1195
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 51085-52-0
CAS 51085-52-0PubChem CID 162624

Benzenamine, 2-methyl-5-nitro-, hydrochloride (1:1)

IUPAC name
2-methyl-5-nitroaniline;hydrochloride
Molecular formula
C7H9ClN2O2
Molecular weight
188.61 g/mol
Exact mass
188.0352552 Da
Topological polar surface area
71.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
2
Defined stereocentres
0

Also known as

Benzenamine, 2-methyl-5-nitro-, monohydrochlorideEINECS 256-960-84-Nitro-2-aminotoluene, monohydrochloride2-Methyl-5-nitrobenzenamine, hydrochlorideo-Toluidine, 5-nitro-, hydrochlorideRefChem:1172122-methyl-5-nitroaniline hydrochloride5-Nitro-o-toluidine hydrochloride
5 more reported names
5-Nitro-o-toluidinium chlorideVA82SU8KF8YTODVWJSAZXJHG-UHFFFAOYSA-N2-methyl-5-nitroanilinehydrochloride2-Methyl-5-nitroaniline--hydrogen chloride (1/1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 99-55-8
CAS 99-55-8PubChem CID 7444

2-Methyl-5-Nitroaniline

5-nitro-o-toluidine is a C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine. It is functionally related to an o-toluidine. — ChEBI

IUPAC name
2-methyl-5-nitroaniline
Molecular formula
C7H8N2O2
Molecular weight
152.15 g/mol
Exact mass
152.058577502 Da
XLogP3
1.9
Topological polar surface area
71.8 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

5-NITRO-O-TOLUIDINEScarlet G Base2-Methyl-5-nitrobenzenamine4-Nitro-2-aminotolueneFast Scarlet GPNOTFast Scarlet G Base3-Nitro-6-methylaniline
16 more reported names
Devol Scarlet BFast scarlet base G6-Methyl-3-nitroanilineDaito Scarlet Base GDiabase Scarlet G5-Nitro-2-toluidineScarlet Base NSPBenzenamine, 2-methyl-5-nitro-1-Amino-2-methyl-5-nitrobenzeneFast Red SG Baseo-Toluidine, 5-nitro-Fast Scarlet Base JFast Scarlet J SaltFast Scarlet T BaseLake Scarlet G BaseAmarthol Fast Scarlet G Base
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2]

Chemical / IUPAC name

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
99-55-8 [1] / 51085-52-0 [2]
EC
202-765-8 [1] / 256-960-8 [2]
Annex
II
Entry number
1195

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1199
Nearby record in the same annex

Oxadiargyl (ISO)

CAS: 39807-15-3
EC: 254-637-6

What Annex II means for 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2]

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 99-55-8 [1] / 51085-52-0 [2] is the unique numerical identifier assigned to 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2]

This page summarizes one Annex II record for 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 5-Nitro-o-toluidine [1]; 5-Nitro-o-toluidine hydrochloride [2], but confirm any final regulatory decision against the current official annex wording and source files.

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