What is CAS 120-71-8 for 6-Methoxy-m-toluidine (p-Cresidine)?

CAS 120-71-8 is the unique numerical identifier assigned to 6-Methoxy-m-toluidine (p-Cresidine) by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 1162 CMR21/10/2010

6-Methoxy-m-toluidine (p-Cresidine)

Q: Is 6-Methoxy-m-toluidine (p-Cresidine) banned in EU cosmetics?

Yes. 6-Methoxy-m-toluidine (p-Cresidine) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

Q: What does the CMR classification mean for 6-Methoxy-m-toluidine (p-Cresidine)?

6-Methoxy-m-toluidine (p-Cresidine) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may only be used if assessed safe by the SCCS.

Q: How do I check if my product formula contains 6-Methoxy-m-toluidine (p-Cresidine)?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

6-Methoxy-m-toluidine (p-Cresidine) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1162

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 120-71-8

CAS 120-71-8PubChem CID 8445

2-Methoxy-5-Methylaniline

P-cresidine appears as white to silver-gray odorless crystals. (NTP, 1992) — CAMEO Chemicals

IUPAC name: 2-methoxy-5-methylaniline

Molecular formula: C8H11NO
Molecular weight: 137.18 g/mol
Exact mass: 137.084063974 Da
XLogP3: 1.7
Topological polar surface area: 35.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

P-CRESIDINECresidine5-Methyl-o-anisidinepara-CresidineKrezidin2-Amino-4-methylanisole3-Amino-4-methoxytoluene4-Methoxy-m-toluidine

16 more reported names

Krezidine1-Amino-2-methoxy-5-methylbenzene4-Methyl-2-aminoanisoleAzoic Red 362-Methoxy-5-methylbenzenamineo-Anisidine, 5-methyl-C.I. Azoic Red 833-Amino-p-cresol methyl etherNCI-C02982m-Amino-p-cresol, methyl esterortho-Anisidine, 5-methyl-3-Amino-para-cresol, methyl ethermeta-Amino-para-cresol, methyl etherNSC61624C11L78UR3NSC-6162

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:82307
ChEMBL:CHEMBL398755
EPA DTXSID:DTXSID1020350
PubMed:33211169
PubMed:26338220
PubMed:26198647
PubMed:22751261
PubMed:20335511
PubMed:19415693
PubMed:16257849
PubMed:15962942
PubMed:12512871
PubMed:9715508
PubMed:9385384
PubMed:8093862

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8445

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 450 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Boiling Point: 455 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: 235 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 235 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Color/Form: White crystals Source: Hazardous Substances Data Bank (HSDB)

Density: 1 (NTP, 1992) Source: CAMEO Chemicals

Flash Point: greater than 230 °F (NTP, 1992) Source: CAMEO Chemicals
Flash Point: 111 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Flash Point: 111 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

LogP: log Kow= 1.74 Source: Hazardous Substances Data Bank (HSDB)
LogP: 1.67 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 126 to 129 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 51.5 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 51.5 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Physical Description: P-cresidine appears as white to silver-gray odorless crystals. (NTP, 1992) Source: CAMEO Chemicals
Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
Physical Description: White solid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: WHITE CRYSTALS. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Solubility: less than 1 mg/mL at 72 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Slightly soluble in water, chloroform. Soluble in ether, benzene, petroleum ether, and ethanol. Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water: poor Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Vapor Pressure: 0.02 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: Vapor pressure, Pa at 25 °C: 1.4 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

IARC Carcinogenic Agent: para-Cresidine Source: International Agency for Research on Cancer (IARC)
IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
IARC Monographs: Volume 27: (1982) Some Aromatic Amines, Anthraquinones and Nitroso Compounds, and Inorganic Fluorides Used in Drinking-water and Dental Preparations; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
Substance: p-Cresidine Source: NTP Technical Reports
NTP Technical Report: TR-142: Bioassay of p-Cresidine for Possible Carcinogenicity (CASRN 120-71-8) (1979 ) Source: NTP Technical Reports
Peer Review Date: 06/29/78 Source: NTP Technical Reports
Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Male Mice: Clear Evidence Source: NTP Technical Reports
Conclusion for Female Mice: Clear Evidence Source: NTP Technical Reports

Exposure Routes: The substance can be absorbed into the body by inhalation and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H319 (23.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H350 (99.4%): May cause cancer [Danger Carcinogenicity] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 173 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P308+P316, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H350: May cause cancer [Danger Carcinogenicity] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Environmental Bioconcentration: BCFs of <4.6 to 10 were measured for p-cresidine(1,2). In a bioconcentration test using orange-red killifish, p-cresidine was listed as a compound which is non accumulative or of low accumulation in aquatic organisms(3). According to a classification scheme(4), these BCF values suggest that bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 53(SRC), determined from a log Kow of 1.74(2) and a regression-derived equation(3), indicates that p-cresidine is expected to have high mobility in soil(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in suspended solids and sediments due to the high reactivity of the aromatic amino group(4,5). Volatilization of p-cresidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(6). p-Cresidine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.5X10-2 mm Hg(SRC), determined from a fragment constant method(7). p-Cresidine reached 0.7% of its theoretical BOD in 2 weeks using the Japanese MITI test(8), suggesting that biodegradation is not a rapid environmental fate process in soils(SRC). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 53(SRC), determined from a log Kow of 1.74(2) and a regression-derived equation(3), indicates that p-cresidine is not expected to adsorb to suspended solids and sediment(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in suspended solids and sediments due to the high reactivity of the aromatic amino group(4,5). Volatilization from water surfaces may occur slowly(3) based upon an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(6). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 23 and 169 days, respectively(SRC). According to a classification scheme(7), a BCF of <4.6(8), suggests bioconcentration in aquatic organisms is low(SRC). p-Cresidine reached 0.7% of its theoretical BOD in 2 weeks using the Japanese MITI test(8), suggesting that biodegradation is not a fast environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), p-cresidine, which has an estimated vapor pressure of 2.5X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase p-cresidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hrs(SRC), calculated from its rate constant of 2.2X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Source: Hazardous Substances Data Bank (HSDB)

Consumer Uses: Intermediate Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Dye Source: EPA Chemical Data Reporting (CDR)

Sources/Uses: Chemical intermediate for dyes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For p-cresidine (USEPA/OPP Pesticide Code: 042002) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Chem int for dyes (e.g., FD&C Red 40 and Direct Violet 9) Source: Hazardous Substances Data Bank (HSDB)
Uses: Substance listed with specific concentration in tattoo ink and/or permanent make up according to EU Commission Regulation 2020/2081. The concentration limit (by weight) is 0.0005%. Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

6-Methoxy-m-toluidine (p-Cresidine)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1B	✓	—	—

Key data

CAS

120-71-8

204-419-1

Annex

Entry number

1162

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1161