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Annex II Entry 1168 CMR12/08/2019

Nonylphenol [1]; 4-Nonylphenol, branched [2]

Nonylphenol [1]; 4-Nonylphenol, branched [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1168
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 25154-52-3
CAS 25154-52-3PubChem CID 67296

Nonylphenol

Nonylphenol appears as a thick, yellowish liquid with a slight phenolic odor. Insoluble in water. Flash point 285 °F. Burns although difficult to ignite. May irritate the skin. Used in the manufacture of oil additives, surfactants, fungicide preparations and plastics and rubber. — CAMEO Chemicals

IUPAC name
2-nonylphenol
Molecular formula
C15H24O
Molecular weight
220.35 g/mol
Exact mass
220.182715385 Da
XLogP3
6.2
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Phenol, nonyl-Nonyl phenoln-NonylphenolHydroxyl No. 253Prevostsel VON-100RefChem:88777Nonanal-methyl anthranilateNonyl phenol (mixed isomers)
16 more reported names
79F6A2ILP5NSC-71410246-672-0136-83-4o-NonylphenolPhenol, 2-nonyl-2-n-nonylphenol24R8721A3SUNII-24R8721A3S2-n-nonyl-phenolEINECS 205-263-7Ortho-n-nonyl-phenolNonylphenol (technical)BIDD:ER0079Nonylphenol(mixture of isomers)MSK8703
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nonylphenol [1]; 4-Nonylphenol, branched [2]

Chemical / IUPAC name

Nonylphenol [1]; 4-Nonylphenol, branched [2]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/552 - Shall not be placed on the market, or used, as substance or in mixtures in concentrations equal to ot greater than 0.1% by weight

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
25154-52-3 [1] / 84852-15-3 [2]
EC
246-672-0 [1] / 284-325-5 [2]
Annex
II
Entry number
1168

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1167
Nearby record in the same annex

Naphthalene

CAS: 91-20-3
EC: 202-049-5
Annex II 1165
Nearby record in the same annex

2-Nitrotoluene

CAS: 88-72-2
EC: 201-853-3
Annex II 1175
Nearby record in the same annex

Phenol

CAS: 108-95-2
EC: 203-632-7

What Annex II means for Nonylphenol [1]; 4-Nonylphenol, branched [2]

Nonylphenol [1]; 4-Nonylphenol, branched [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nonylphenol [1]; 4-Nonylphenol, branched [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 25154-52-3 [1] / 84852-15-3 [2] is the unique numerical identifier assigned to Nonylphenol [1]; 4-Nonylphenol, branched [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nonylphenol [1]; 4-Nonylphenol, branched [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nonylphenol [1]; 4-Nonylphenol, branched [2]

This page summarizes one Annex II record for Nonylphenol [1]; 4-Nonylphenol, branched [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nonylphenol [1]; 4-Nonylphenol, branched [2], but confirm any final regulatory decision against the current official annex wording and source files.

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