What is CAS 101-80-4 for 4,4'-Oxydianiline (p-aminophenyl ether) and its salts?

CAS 101-80-4 is the unique numerical identifier assigned to 4,4'-Oxydianiline (p-aminophenyl ether) and its salts by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 1160 CMR15/10/2010

4,4'-Oxydianiline (p-aminophenyl ether) and its salts

Q: How do I check if my product formula contains 4,4'-Oxydianiline (p-aminophenyl ether) and its salts?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

4,4'-Oxydianiline (p-aminophenyl ether) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1160

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 101-80-4

CAS 101-80-4PubChem CID 7579

4,4'-Diaminodiphenyl Ether

4-Aminophenyl ether is an aromatic ether. — ChEBI

IUPAC name: 4-(4-aminophenoxy)aniline

Molecular formula: C12H12N2O
Molecular weight: 200.24 g/mol
Exact mass: 200.094963011 Da
XLogP3: 1.4
Topological polar surface area: 61.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

4,4'-Oxydianiline4,4-Oxydianiline4-Aminophenyl etherOxydianilineDiaminodiphenyl etherDadpeBis(p-aminophenyl) etherBis(4-aminophenyl) ether

16 more reported names

4,4'-Oxybisbenzenaminep,p'-OxydianilineBenzenamine, 4,4'-oxybis-p-Aminophenyl ether4,4-Diaminodiphenyl etherp,p'-Oxybis(aniline)4,4'-OxydiphenylamineOxydi-p-phenylenediamineAniline, 4,4'-oxydi-p,p'-Diaminodiphenyl etherOxybis(4-aminobenzene)4,4'-Diaminobiphenyl oxide4,4'-Diaminodiphenyl oxideBis(4-aminophenyl)ether4,4'-Diaminophenyl oxide4,4'-Oxybisaniline

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:34384
ChEMBL:CHEMBL354663
EPA DTXSID:DTXSID0021094
PubMed:22751261
PubMed:22435290
PubMed:22233638
PubMed:22160135
PubMed:21860525
PubMed:21754434
PubMed:21754087
PubMed:21752381
PubMed:21730539
PubMed:21582198
PubMed:21577659
PubMed:21202654

Evidence from additional scientific databases

EMBL-EBI ChEBI

Exact identifier matchCHEBI:34384

4-Aminophenyl ether

Formula: C12H12N2O
Average mass: 200.241 g/mol
Monoisotopic mass: 200.09496 Da
Formal charge: 0

aromatic ether — is a (CHEBI:35618)

aromatic ether — is a (CHEBI:35618)

Additional curated names

4,4'-Oxybisbenzenamine4,4'-Oxydianiline4-Aminophenyl ether

Cross-references from this source

CAS: 101-80-4 — KEGG COMPOUND
MANUAL_X_REF: C14759 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-01-19. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View

Exact identifier match7579

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 914 °F (NTP, 1992) Source: CAMEO Chemicals
Autoignition Temperature: 490 °C Source: Hazardous Substances Data Bank (HSDB)

Boiling Point: Sublimes (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: >300 °C Source: Hazardous Substances Data Bank (HSDB)

Color/Form: Colorless crystals Source: Hazardous Substances Data Bank (HSDB)

Flash Point: 426 °F (NTP, 1992) Source: CAMEO Chemicals
Flash Point: 219 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Flash Point: 219 °C (closed cup) Source: Hazardous Substances Data Bank (HSDB)

LogP: log Kow = 1.36 Source: Hazardous Substances Data Bank (HSDB)

Melting Point: 367 to 369 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 189 °C (decomposes Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 187 °C Source: PAC Chemical Database, U.S. Department of Energy

Physical Description: 4,4'-diaminodiphenyl ether appears as odorless colorless crystals or an odorless fine, beige powder. (NTP, 1992) Source: CAMEO Chemicals
Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
Physical Description: Colorless solid; [HSDB] Colorless crystalline solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: less than 0.1 mg/mL at 59 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Insoluble in water, benzene, carbon tetrachloride and ethanol; soluble in acetone Source: Hazardous Substances Data Bank (HSDB)

Vapor Pressure: 10 mmHg at 464 °F ; 15 mmHg at 482 °F (NTP, 1992) Source: CAMEO Chemicals
Vapor Pressure: 0.00000436 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: 0.0000003 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy

IARC Carcinogenic Agent: 4,4'-Diaminodiphenyl ether Source: International Agency for Research on Cancer (IARC)
IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
IARC Monographs: Volume 29: (1982) Some Industrial Chemicals and Dyestuffs; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
Substance: 4,4'-Oxydianiline Source: NTP Technical Reports
NTP Technical Report: TR-205: Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4) (1980 ) Source: NTP Technical Reports
Peer Review Date: 02/15/80 Source: NTP Technical Reports
Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Male Mice: Clear Evidence Source: NTP Technical Reports
Conclusion for Female Mice: Clear Evidence Source: NTP Technical Reports

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P318, P319, P321, P330, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P280, P301+P317, P302+P352, P318, P319, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Environmental Bioconcentration: An estimated BCF of 4 was calculated in fish for bis(4-aminophenyl) ether(SRC), using a log Kow of 1.36(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 450(SRC), determined from a structure estimation method(2), indicates that bis(4-aminophenyl) ether is expected to have moderate mobility in soil(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC). Volatilization of bis(4-aminophenyl) ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(5). bis(4-Aminophenyl) ether is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.5X10-6 mm Hg(SRC), determined from a fragment constant method(6). Biodegradation data were not available(SRC, 2009). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 450(SRC), determined from a structure estimation method(2), indicates that bis(4-aminophenyl) ether is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 4(SRC), from its log Kow of 1.36(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). bis(4-Aminophenyl) ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Biodegradation data were not available(SRC, 2009). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(4-aminophenyl) ether, which has an estimated vapor pressure of 2.5X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(4-aminophenyl) ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.8 hours(SRC), calculated from its rate constant of 2.1X10-10 cu cm/molecule-sec at 25 °C(3). Particulate-phase bis(4-aminophenyl) ether may be removed from the air by wet or dry deposition(SRC). bis(4-Aminophenyl) ether does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Industry Uses: Monomers Source: EPA Chemical Data Reporting (CDR)

Sources/Uses: Used as a chemical intermediate for polyimide and poly(ester-imide) resins; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: Chem int for polyimide and poly(ester-imide) resins Source: Hazardous Substances Data Bank (HSDB)
Uses: Substance listed with specific concentration in tattoo ink and/or permanent make up according to EU Commission Regulation 2020/2081. The concentration limit (by weight) is 0.0005%. Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	Exact match	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4,4'-Oxydianiline (p-aminophenyl ether) and its salts

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1B	✓	✓	—
Cat. 2	—	—	✓

Key data

CAS

101-80-4

202-977-0

Annex

Entry number

1160

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1159