1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme
1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Triglyme
Triethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. (NTP, 1992) — CAMEO Chemicals
- IUPAC name
- 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
- Molecular formula
- C8H18O4
- Molecular weight
- 178.23 g/mol
- Exact mass
- 178.12050905 Da
- XLogP3
- -0.5
- Topological polar surface area
- 36.9 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:44842
- ChEMBL:CHEMBL1235255
- EPA DTXSID:DTXSID8026224
- PubMed:19562813
- PubMed:16854038
- PubMed:16805630
- PubMed:16701839
- PubMed:15252658
- PubMed:12492325
- PubMed:11430081
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 1166 °F (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 421 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 216 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 216 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.99 at 68 °F (NTP, 1992) - Less dense than water; will float Source: CAMEO Chemicals
- Density: Relative density (water = 1): 0.99 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.986 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 232 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 111 °C o.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: -0.48 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -49 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -45 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Triethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Liquid; [Merck Index] Colorless liquid; [ICSC] Hygroscopic; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Solubility in water: miscible Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 0.9 mmHg at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.04 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.12 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H319 (22.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H360 (99%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P264+P265, P280, P305+P351+P338, P318, P337+P317, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 310 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used as a solvent; [Merck Index] Used as a solvent for gases and coupling immiscible liquid; [NTP] Not produced commercially in the EU; [Glycol Ethers Online] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme
Regulatory information
SCCS opinions
- Opinion concerning Request for Confirmation of the SCCNFP Opinion 0474/01 on Chemical Ingredients in Cosmetic Products Classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to Council Directive 67/548/EEC
- Opinion concerning Request for Confirmation of the SCCNFP Opinion 0474/01 on Chemical Ingredients in Cosmetic Products Classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to Council Directive 67/548/EEC
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | — | — | ✓ |
Key data
Related records for 1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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What Annex II means for 1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme
1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record 1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme
This page summarizes one Annex II record for 1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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