EU cosmetic ingredients, restrictions and safety

Annex II Entry 1142 CMR21/10/2010

Ethylene glycol dimethyl ether (EGDME)

Ethylene glycol dimethyl ether (EGDME) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare

Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1142

CMR

Record details

Chemical name

Ethylene glycol dimethyl ether (EGDME)

Regulatory information

Regulation

(EC) 2009/1223

SCCS opinions

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1B	—	—	✓

Key data

CAS

EC

Annex

Entry number

1142

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1141

Nearby record in the same annex

1,2,3-Trichloropropane

CAS: 96-18-4

EC: 202-486-1

Annex II 1143

Nearby record in the same annex

Dinocap (ISO)

CAS: 39300-45-3

EC: 254-408-0

Annex II 1140

Nearby record in the same annex

Chloroprene (stabilized); (2-Chlorobuta-1,3-diene)

CAS: 126-99-8

EC: 204-818-0

Annex II 1144

Nearby record in the same annex

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

CAS: 25376-45-8 [1] / 95-80-7 [2] / 823-40-5 [3]

EC: 246-910-3 [1] / 202-453-1 [2] / 212-513-9 [3]

Annex II 1139

Nearby record in the same annex

1-Bromopropane; n-Propyl bromide

CAS: 106-94-5

EC: 203-445-0

Annex II 1145

Nearby record in the same annex

p-Chlorobenzotrichloride

CAS: 5216-25-1

EC: 226-009-1

Annex II 1138

Nearby record in the same annex

Isoprene (stabilized); (2-Methyl-1,3-butadiene)

CAS: 78-79-5

EC: 201-143-3

Annex II 1146

Nearby record in the same annex

Diphenylether; Octabromo derivate

CAS: 32536-52-0

EC: 251-087-9

Annex II 1137

Nearby record in the same annex

Isobutyl nitrite

CAS: 542-56-3

EC: 208-819-7

Annex II 1147

Nearby record in the same annex

1,2-Bis(2-methoxyethoxy)ethane; Triethylene glycol dimethyl ether; (TEGDME); triglyme

CAS: 112-49-2

EC: 203-977-3

Annex II 1136

Nearby record in the same annex

Peru balsam (INCI name: Myroxylon pereirae), when used as a fragrance ingredient

CAS: 8007-00-9

EC: 232-352-8

Annex II 1148

Nearby record in the same annex

Tetrahydrothiopyran-3-carboxaldehyde

CAS: 61571-06-0

EC: 407-330-8

What Annex II means for Ethylene glycol dimethyl ether (EGDME)

Ethylene glycol dimethyl ether (EGDME) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009. No concentration limit applies — the presence of this substance in any cosmetic product placed on the EU market is not permitted regardless of use level.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).
This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Ethylene glycol dimethyl ether (EGDME) is listed in Annex II of EU Cosmetics Regulation 1223/2009 as a prohibited substance. It must not be present in any cosmetic product placed on the EU market at any concentration.

CAS 110-71-4 is the unique numerical identifier assigned to Ethylene glycol dimethyl ether (EGDME) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Ethylene glycol dimethyl ether (EGDME) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Open INCI Checker

Source note for Annex II record Ethylene glycol dimethyl ether (EGDME)

This page summarizes one Annex II record for Ethylene glycol dimethyl ether (EGDME) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Ethylene glycol dimethyl ether (EGDME), but confirm any final regulatory decision against the current official annex wording and source files.

View sources View updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Ethylene glycol dimethyl ether (EGDME) and other flagged EU annex records in one pass.

Compare entries

Compare Ethylene glycol dimethyl ether (EGDME) side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.