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Annex II Entry 1144 CMR31/07/2020

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1144
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 823-40-5
CAS 823-40-5PubChem CID 13205

2,6-Diaminotoluene

2,6-diaminotoluene is a diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups. It has a role as a mutagen. It is a diamine and a primary amino compound. It derives from a hydride of a toluene. — ChEBI

IUPAC name
2-methylbenzene-1,3-diamine
Molecular formula
C7H10N2
Molecular weight
122.17 g/mol
Exact mass
122.084398327 Da
XLogP3
0.9
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2,6-ToluenediamineToluene-2,6-diamine1,3-Benzenediamine, 2-methyl-2-Methyl-m-phenylenediamine2-Methyl-1,3-benzenediamine2,6-Tolylenediamine2,6-Toluylenediamine2,6-Diamino-1-methylbenzene
16 more reported names
2-Methyl-1,3-phenylenediamineo-Toluene diamineToluene, 2,6-diamino-1,3-DIAMINO-2-METHYLBENZENERODOL 26DATNSC-147490H838Q10551CHEBI:762882,6-DATRefChem:83124212-513-9EINECS 212-513-9NSC 147490CCRIS 3031HSDB 4131Tolylene-2,6-diamine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 95-80-7
CAS 95-80-7PubChem CID 7261

2,4-Diaminotoluene

2,4-diaminotoluene is an aminotoluene that is para-toluidine with an additional amino group at position 2. It has a role as a metabolite. It is functionally related to a p-toluidine. — ChEBI

IUPAC name
4-methylbenzene-1,3-diamine
Molecular formula
C7H10N2
Molecular weight
122.17 g/mol
Exact mass
122.084398327 Da
XLogP3
0.1
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2,4-ToluenediamineTOLUENE-2,4-DIAMINEDeveloper mtdm-ToluenediamineDeveloper TNako TMTFouramine JDeveloper MT
16 more reported names
Fourrine M1,3-Benzenediamine, 4-methyl-Benzofur MTDeveloper DBJEucanine GBm-TolylenediaminePelagol JTertral GPelagol Grey JBrown for Fur TDeveloper MT-CFZogen developer HFourrine 944-Methyl-1,3-benzenediamineTolylene-2,4-diamineZoba GKE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

Chemical / IUPAC name

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓——
Cat. 2—✓✓

Key data

CAS
25376-45-8 [1] / 95-80-7 [2] / 823-40-5 [3]
EC
246-910-3 [1] / 202-453-1 [2] / 212-513-9 [3]
Annex
II
Entry number
1144

Inventory links for Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1143
Nearby record in the same annex

Dinocap (ISO)

CAS: 39300-45-3
EC: 254-408-0

What Annex II means for Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 25376-45-8 [1] / 95-80-7 [2] / 823-40-5 [3] is the unique numerical identifier assigned to Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3]

This page summarizes one Annex II record for Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Diaminotoluene[1]; [4-methyl-m-phenylene diamine][2]; [2-methyl-m-phenylene diamine][3], but confirm any final regulatory decision against the current official annex wording and source files.

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