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Annex II Entry 109 15/10/2010

Curare and curarine

Curare and curarine is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 109

Chemical identity and properties

PubChem 2D chemical structure for CAS 22260-42-0
CAS 22260-42-0PubChem CID 198004

(13aS,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,1,14,14-tetramethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium

IUPAC name
(1S,16S)-10,25-dimethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,21-diol
Molecular formula
C38H44N2O6+2
Molecular weight
624.8 g/mol
Exact mass
624.31993713 Da
XLogP3
6.0
Topological polar surface area
77.4 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
2

Also known as

Curarine(+)-CurarineBebeerinium, 2,2'-dimethyl-(+)-2,2'-DimethylbebeerineQ06KJ82A9STubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'alpha)-RefChem:9056427',12'-Dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyltubocuraranium
16 more reported names
244-880-6N,N'-Dimethylbebeerinium2,2'-DimethylbebeeriniumCurarine (C33 alkaloid)Curarine (C38 alkaloid)Curarine (C38 alkaloid), (+)-EINECS 244-880-6UNII-Q06KJ82A9SD-CURARINEPXXYOLIWFSWZNP-KYJUHHDHSA-PTubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'-alpha)-Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'.alpha.)-BEBEERINE, 2,2'-DIMETHYL-, (+)-7',12'-Dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyltubocuraran-2,2'-diium1401-89-47',12'-Dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-1beta,1'alpha-tubocuraran-2,2'-diium
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 8063-06-7
CAS 8063-06-7PubChem CID 23422

(+)-Tubocurarine chloride pentahydrate

IUPAC name
(1S,16R)-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-30-aza-15-azoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,21-diol;chloride;pentahydrate;hydrochloride
Molecular formula
C37H52Cl2N2O11
Molecular weight
771.7 g/mol
Exact mass
770.2948159 Da
Topological polar surface area
85.6 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
13
Covalent units
8
Defined stereocentres
2

Also known as

6989-98-6TUBOCURARINE CHLORIDE PENTAHYDRATE(+)-Tubocurarine chloride hydrochloride pentahydrateD-Tubocurarine (chloride pentahydrate)Tubocurarine dichloride pentahydrateTUBOCURARINE CHLORIDE HYDROCHLORIDE HYDRATE(+)-Tubocurarine chlorideUNII-900961Z8VR
16 more reported names
Prestwick_489Tubocurarine chloride [USP:INN:BAN:JAN]Tubocurarine chloride (USP)Tubocurarine chloride hydrate (JAN)HB2050TUBOCURARINE CHLORIDE [VANDF]TUBOCURARINE CHLORIDE [MART.]TUBOCURARINE CHLORIDE [USP-RS]TUBOCURARINE CHLORIDE [WHO-IP]NSC 757362MS-31399TUBOCURARINE CHLORIDE [ORANGE BOOK]HY-125901CS-0102809D-TUBOCURARINE DICHLORIDE PENTAHYDRATETUBOCURARINE CHLORIDE [USP MONOGRAPH]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Curare and curarine

Chemical / IUPAC name

Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'-alpha)- (Curarine)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
8063-06-7 / 22260-42-0
EC
232-511-1 / 244-880-6
Annex
II
Entry number
109

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 105
Nearby record in the same annex

Convallatoxin

CAS: 508-75-8
EC: 208-086-3

What Annex II means for Curare and curarine

Curare and curarine is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Curare and curarine is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 8063-06-7 / 22260-42-0 is the unique numerical identifier assigned to Curare and curarine by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Curare and curarine

This page summarizes one Annex II record for Curare and curarine from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Curare and curarine, but confirm any final regulatory decision against the current official annex wording and source files.

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