EU cosmetic ingredients, restrictions and safety

Annex II Entry 113 17/10/2010

Cyclomenol (INN) and its salts

Cyclomenol (INN) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 113

Chemical identity and properties

PubChem 2D chemical structure for CAS 5591-47-9

CAS 5591-47-9PubChem CID 71662

Cyclomenol

Cyclomenol is a small molecule drug. Cyclomenol has a monoisotopic molecular weight of 204.15 Da. — DrugBank

IUPAC name: 2-cyclohexyl-3,5-dimethylphenol

Molecular formula: C14H20O
Molecular weight: 204.31 g/mol
Exact mass: 204.151415257 Da
XLogP3: 4.8
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

CyclomenolumCiclomenolCyclomenol [INN:DCF]2-Cyclohexyl-3,5-xylenolTB885DRP1JCiclomenol [INN-Spanish]Cyclomenolum [INN-Latin]UNII-TB885DRP1J

3 more reported names

EINECS 227-002-6CYCLOMENOL [INN]ZEEKNRMEDJKDMO-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL2104180
EPA DTXSID:DTXSID90204510

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cyclomenol (INN) and its salts

Chemical / IUPAC name

2-Cyclohexyl-3,5-xylenol

Regulatory information

Regulation

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Key data

CAS

EC

Annex

Entry number

113

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 112

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What Annex II means for Cyclomenol (INN) and its salts

Cyclomenol (INN) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Cyclomenol (INN) and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 5591-47-9 is the unique numerical identifier assigned to Cyclomenol (INN) and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex II record Cyclomenol (INN) and its salts

This page summarizes one Annex II record for Cyclomenol (INN) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cyclomenol (INN) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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