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Annex II Entry 105 15/10/2010

Convallatoxin

Convallatoxin is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 105

Chemical identity and properties

PubChem 2D chemical structure for CAS 508-75-8
CAS 508-75-8PubChem CID 441852

Convallatoxin

Convallatoxin is a cardenolide glycoside that consists of strophanthidin having a 6-deoxy-alpha-L-mannopyranosyl (L-rhamnosyl) group attached at position 3. It has a role as a metabolite and a vasodilator agent. It is a steroid aldehyde, a steroid lactone, an alpha-L-rhamnoside, a 14beta-hydroxy steroid, a 19-oxo steroid and a 5beta-hydroxy steroid. It is functionally related to a strophanthidin. — ChEBI

IUPAC name
(3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
Molecular formula
C29H42O10
Molecular weight
550.6 g/mol
Exact mass
550.27779753 Da
XLogP3
-0.7
Topological polar surface area
163.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
10
Covalent units
1
Defined stereocentres
13

Also known as

CorglyconeConvallatonCorglykonKorglykonConvallotoxinConvallaotoxinCorglyconConvallatoxoside
16 more reported names
JY264VIR1YStrophanthidin 3-O-alpha-L-rhamnosideCHEBI:27663Strophanthidin, 3-(6-deoxy-alpha-L-mannopyranoside)Strophanthidin alpha-L-rhamnosideRhamnoside, strophanthidin-3, alpha-L-3beta-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-5beta-card-20(22)-enolide3beta-(6-deoxy-alpha-L-mannopyranosyloxy)-5,14-dihydroxy-19-oxo-5beta-card-20(22)-enolideMannopyranoside, strophanthidin-3,6-deoxy-, alpha-L-NSC-407808Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)-korglycon(3beta,5beta)-3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-card-20(22)-enolidestrophanthidin-alpha-L-rhamnoside5beta,14beta-Dihydroxy-19-oxo-3beta((alpha-L-rhamnopyranosyl)oxy)card-20,22-enolide5beta,14beta-Dihydroxy-19-oxo-3beta[(alpha-L-rhamnopyranosyl)oxy]card-20,22-enolide
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Convallatoxin

Chemical / IUPAC name

Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)-

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
508-75-8
EC
208-086-3
Annex
II
Entry number
105

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 109
Nearby record in the same annex

Curare and curarine

CAS: 8063-06-7 / 22260-42-0
EC: 232-511-1 / 244-880-6

What Annex II means for Convallatoxin

Convallatoxin is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Convallatoxin is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 508-75-8 is the unique numerical identifier assigned to Convallatoxin by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Convallatoxin

This page summarizes one Annex II record for Convallatoxin from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Convallatoxin, but confirm any final regulatory decision against the current official annex wording and source files.

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