EU cosmetic ingredients, restrictions and safety

Annex II Entry 108 17/10/2010

1-Butyl-3-(N-crotonoylsulphanilyl)urea

1-Butyl-3-(N-crotonoylsulphanilyl)urea is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 108

Chemical identity and properties

PubChem 2D chemical structure for CAS 52964-42-8

CAS 52964-42-8PubChem CID 90473209

1-Butyl-3-(N-crotonylsulfanilyl)urea

IUPAC name: (E)-N-[4-(butylcarbamoylsulfamoyl)phenyl]but-2-enamide

Molecular formula: C15H21N3O4S
Molecular weight: 339.4 g/mol
Exact mass: 339.12527733 Da
XLogP3: 2.2
Topological polar surface area: 113.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

CROTULINCrotonoylcarbutamideUNII-JC5Y4Y2O5VJC5Y4Y2O5VUrea, 1-butyl-3-(N-crotonoylsulfanilyl)-1-Butyl-3-(N-crotonylsulfanilyl)urea [WHO-DD]2-Butenamide, N-(4-((((butylamino)carbonyl)amino)sulfonyl)phenyl)-RefChem:75259

1 more reported name

N-Butyl-N'-(N-crotonoyl-sulfanilyl)-harnstoff

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID301338055

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1-Butyl-3-(N-crotonoylsulphanilyl)urea

Regulatory information

Regulation

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Key data

CAS

EC

—

Annex

Entry number

108

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What Annex II means for 1-Butyl-3-(N-crotonoylsulphanilyl)urea

1-Butyl-3-(N-crotonoylsulphanilyl)urea is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1-Butyl-3-(N-crotonoylsulphanilyl)urea is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 52964-42-8 is the unique numerical identifier assigned to 1-Butyl-3-(N-crotonoylsulphanilyl)urea by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex II record 1-Butyl-3-(N-crotonoylsulphanilyl)urea

This page summarizes one Annex II record for 1-Butyl-3-(N-crotonoylsulphanilyl)urea from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1-Butyl-3-(N-crotonoylsulphanilyl)urea, but confirm any final regulatory decision against the current official annex wording and source files.

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