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RestrictedBinding ruleSAOriginal is EnglishOfficial-source import checked

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-?-2-benzopyran

Listed by the Saudi Food and Drug Authority as restricted in cosmetic products; open the cited detail for the current conditions.

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Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
Listed by the Saudi Food and Drug Authority as restricted in cosmetic products; open the cited detail for the current conditions.
Conditions and restrictions
If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-?-2-benzopyran
CAS
1222-05-5
EC
214-946-9
Identity mapping
cas_number
Linked ingredient
HEXAMETHYLINDANOPYRAN
Search this identity across the siteCAS 1222-05-5EC 214-946-9

Linked CosIng identity data

Names and aliases

HEXAMETHYLINDANOPYRAN

CosIng description: 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6-c)pyran; 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran; abbalide; galaxolide; HHCB; pearlide

Recorded cosmetic function: FRAGRANCE, PERFUMING

Function pages:FRAGRANCE, PERFUMING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

2 market datasets
PubChem 2D chemical structure for CAS 1222-05-5
CAS 1222-05-5PubChem CID 91497

Verified chemistry for CAS 1222-05-5

Galaxolide

IUPAC name
4,6,6,7,8,8-hexamethyl-1,3,4,7-tetrahydrocyclopenta[g]isochromene
Molecular formula
C18H26O
Molecular weight
258.4 g/mol
Exact mass
258.198365449 Da
Monoisotopic mass
258.198365449 Da
XLogP3
4.8
Topological polar surface area
9.2 Ų
Molecular complexity
357.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

AbbalideGaloxolideHHCBPearlideGalaxolide WhitehexamethylindanopyranCyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-Hexahydrohexamethyl cyclopentabenzopyran
16 more reported names
1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyranCHEBI:83784Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6-c)pyranCyclopenta(g)-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyranhexahydro-hexamethylcyclopenta-benzopyranRefChem:633508214-946-94,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydroindeno[5,6-c]pyran1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta(g)-2-benzopyranEINECS 214-946-9CCRIS 8402Galaxolide 1
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
2
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
3
3D hydrophobes
2
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
5
Effective 3D rotors
1.4
Machine-readable structure identifiers
SMILES
CC1COCC2=CC3=C(C=C12)C(C(C3(C)C)C)(C)C
InChI
InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3
InChIKey
ONKNPOPIGWHAQC-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match91497

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H400 (97.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2093 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Toxicity Summary: IDENTIFICATION AND USE: Galaxolide (HHCB) is an almost colorless viscous liquid. It is a synthetic, artificial musk fragrance, which is used as a laundry detergent fragrance, as well as an ingredient in perfumes, soaps, and cosmetics. HUMAN STUDIES: No irritation was observed in any of the 42 subjects tested in human repeated insult patch test even after repeated occlusive applications of undiluted material. High concentrations of HHCB can affect steroidogenesis in vitro using the H295R cell line. HHCB was not genotoxic in the micronucleus test with human lymphocytes in vitro in the presence and absence of metabolic activation. ANIMAL STUDIES: HHCB was added to the diet of rats at levels calculated to result in mean daily doses of 5, 15, 50 or 150 mg HHCB/kg. On completion of the 90-day treatment period, three males and three females from the high dose and control groups were maintained for a treatment free period of 4 weeks. No adverse effects were revealed from clinical examination or following extensive histopathological examinations. There were no significant findings at any dose level. Developmental study in rats described axial skeletal malformations at 500 mg/kg per day. In Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A BCF of 1,584 was measured in fish for galaxolide(SRC), using bluegill sunfish (Lepomis macrochirus) which were exposed to concentrations of 1 and 10 mg/L over an 28-day period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC). A polar metabolite accounting for 9-24% of the total radioactivity in tissue was detected(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that galaxolide is expected to be immobile in soil(SRC). Volatilization of galaxolide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 5.45X10-4 mm Hg(3), and water solubility, 1.75 mg/L(3). However, adsorption to soil is expected to attenuate volatilization(SRC).) Galaxolide is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). A biodegradation half-life in soil of 4 months(3) indicates that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that galaxolide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.1X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 5.45X10-4 mm Hg(4), and water solubility, 1.75 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 18 hrs and 10 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 31 months if adsorption is considered(5). According to a classification scheme(6), a BCF of 1584(4) suggests the potential for bioconcentration in aquatic organisms is very high(SRC). A release of 0% CO2 in four weeks using an effluent from a semi-continuous activated sludge (SCAS) in the OECD 302 test(4) indicates that biodegradation is not an important environmental fate process in wate Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), galaxolide, which has a vapor pressure of 5.45X10-4 mm Hg at 25 °C((SRC), determined from a fragment constant method(2)), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase galaxolide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be approximately 10 hrs(SRC), calculated from its rate constant of 2.60X10-11 cu cm/molecule-sec at 25 °C(3). Particulate-phase galaxolide may be removed from the air by wet and dry deposition(SRC). Galaxolide does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Saudi SFDA prohibited and restricted ingredient lists
Source reference
SFDA restricted list, page 24, row 7
Source record ID
restricted-23-7
Source version
live-snapshot-2026-08-30
Source language
English
Translation status
Original is English
Snapshot checked
2026-08-30 05:18 UTC
Validation method
complete SFDA paginated HTML snapshot; strict page/row counts
SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a

Registered dataset notes

Dataset coverage
Prohibited and restricted substances with CAS, EC and conditions
Authority note
Official SFDA dated lists; version and hash each release
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2090
current Saudi Arabia records
364
records marked Restricted
2090
records from this source version
1991
market records with CAS identity

Status distribution

Prohibited: 1726Restricted: 364

Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Saudi Arabia market context

Complete official list index

Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026

Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.

Verification checklist

  1. Search names and CAS across both SFDA lists.
  2. Open the cited restricted-entry detail and apply every condition.
  3. Check current SFDA/GSO technical regulations and updates.
  4. Complete eCosma notification, label and responsible-party requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-?-2-benzopyran” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search names and CAS across both SFDA lists.
  3. Open the cited restricted-entry detail and apply every condition.
  4. Check current SFDA/GSO technical regulations and updates.
  5. Complete eCosma notification, label and responsible-party requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

The record cites SFDA restricted list, page 24, row 7, source version live-snapshot-2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-?-2-benzopyran. SFDA restricted list, page 24, row 7. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/11562/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Saudi Arabia

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: live-snapshot-2026-08-30

What it does not prove

No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source