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ProhibitedBinding ruleSAOriginal is EnglishOfficial-source import checked

Nickel dinitrate [1]; Nitric acid, nickel salt [2]

Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.

All Saudi Arabia recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Nickel dinitrate [1]; Nitric acid, nickel salt [2]
CAS
13138-45-9; 14216-75-2
EC
Not supplied in this source row
Identity mapping
standalone:official_sfda_record
Search this identity across the siteCAS 13138-45-9CAS 14216-75-2

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

4 market datasets
PubChem 2D chemical structure for CAS 13138-45-9
CAS 13138-45-9CAS 14216-75-2PubChem CID 25736

Verified chemistry for CAS 13138-45-9

Nickel nitrate

IUPAC name
nickel(2+) dinitrate
Molecular formula
N2NiO6
Molecular weight
182.70 g/mol
Exact mass
181.910977 Da
Monoisotopic mass
181.910977 Da
Topological polar surface area
126.0 Ų
Molecular complexity
18.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Rotatable bonds
0
Heavy atoms
9
Covalent units
3

Names and synonyms reported to PubChem

Nickel(II) nitrateNickel dinitrateNickelous nitrateNickel bis(nitrate)Nickel(2+) nitrateNitric acid, nickel(2+) saltNickel nitrate (Ni(NO3)2)Nickel(II) nitrate (1:2)
16 more reported names
Nitric acid, nickel(II) salt50L0S38I2DNiccolum NitricumRefChem:6059NICKEL(2+) ION DINITRATE236-068-5nickel(2+);dinitrateNitric acid, nickel(2+) salt (2:1)CCRIS 5562HSDB 1829N2NiO6Nitric acid, nickel saltEINECS 236-068-5UN2725UNII-50L0S38I2DNickel Nitrate GFAA Matrix Modifier: 1% Ni(NO3)2 in 2% HNO3
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Ni+2]
InChI
InChI=1S/2NO3.Ni/c2*2-1(3)4;/q2*-1;+2
InChIKey
KBJMLQFLOWQJNF-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match25736

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: INHALATION: move to fresh air; got medical attention if exposure has been severe.; INGESTION: give large amount of water.; EYES: flush with water for at least 15 min.; SKIN: wash with soap and water. (USCG, 1999) Source: CAMEO Chemicals
  • ERG2024, Guide 140 (Nickel nitrate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H360D ***: May damage the unborn child [Danger Reproductive toxicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H272 (94.3%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (99.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (99.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (99.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (98.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (99.3%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (90.1%): May cause cancer [Danger Carcinogenicity]; H360 (90.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (99.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (99.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 283 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H272 (100%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P220, P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P318, P321, P333+P317, P342+P316, P362+P364, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L41) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. Nitrat Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Saudi SFDA prohibited and restricted ingredient lists
Source reference
SFDA prohibited list, page 142, row 6
Source record ID
prohibited-141-6
Source version
live-snapshot-2026-08-30
Source language
English
Translation status
Original is English
Snapshot checked
2026-08-30 05:18 UTC
Validation method
complete SFDA paginated HTML snapshot; strict page/row counts
SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a

Registered dataset notes

Dataset coverage
Prohibited and restricted substances with CAS, EC and conditions
Authority note
Official SFDA dated lists; version and hash each release
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2090
current Saudi Arabia records
1726
records marked Prohibited
2090
records from this source version
1991
market records with CAS identity

Status distribution

Prohibited: 1726Restricted: 364

Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Saudi Arabia market context

Complete official list index

Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026

Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.

Verification checklist

  1. Search names and CAS across both SFDA lists.
  2. Open the cited restricted-entry detail and apply every condition.
  3. Check current SFDA/GSO technical regulations and updates.
  4. Complete eCosma notification, label and responsible-party requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Nickel dinitrate [1]; Nitric acid, nickel salt [2]” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search names and CAS across both SFDA lists.
  3. Open the cited restricted-entry detail and apply every condition.
  4. Check current SFDA/GSO technical regulations and updates.
  5. Complete eCosma notification, label and responsible-party requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

The record cites SFDA prohibited list, page 142, row 6, source version live-snapshot-2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Nickel dinitrate [1]; Nitric acid, nickel salt [2]. SFDA prohibited list, page 142, row 6. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/10995/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Saudi Arabia

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: live-snapshot-2026-08-30

What it does not prove

No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source