Flumioxazin
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Flumioxazin
- CAS
- 103361-09-7
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_sfda_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
2 linked records
Open supporting recordNew Zealand
1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
Current record1 linked record
Open supporting recordVerified chemistry for CAS 103361-09-7
Flumioxazin
- IUPAC name
- 2-(7-fluoro-3-oxo-4-prop-2-ynyl-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydroisoindole-1,3-dione
- Molecular formula
- C19H15FN2O4
- Molecular weight
- 354.3 g/mol
- Exact mass
- 354.10158513 Da
- Monoisotopic mass
- 354.10158513 Da
- XLogP3
- 1.8
- Topological polar surface area
- 66.9 Ų
- Molecular complexity
- 724.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 26
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:8939
- ChEMBL:CHEMBL2133606
- EPA DTXSID:DTXSID7032555
- PubMed:42162654
- PubMed:24753331
- PubMed:22960102
- PubMed:22412731
- PubMed:21919467
- PubMed:21837100
- PubMed:21754562
- PubMed:21754056
- PubMed:21589104
- PubMed:21589037
- PubMed:21587879
- PubMed:21581725
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 9
- 3D rings
- 4
- 3D hydrophobes
- 1
- 3D acceptor features
- 4
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 6
- Effective 3D rotors
- 3.6
Machine-readable structure identifiers
- SMILES
C#CCN1C(=O)COC2=CC(=C(C=C21)N3C(=O)C4=C(C3=O)CCCC4)F- InChI
InChI=1S/C19H15FN2O4/c1-2-7-21-15-9-14(13(20)8-16(15)26-10-17(21)23)22-18(24)11-5-3-4-6-12(11)19(22)25/h1,8-9H,3-7,10H2- InChIKey
FOUWCSDKDDHKQP-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
flumioxazin
A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops.
- Formula
- C19H15FN2O4
- Average mass
- 354.337 g/mol
- Monoisotopic mass
- 354.10159 Da
- Formal charge
- 0
- benzoxazine — is a (CHEBI:46969)
- terminal acetylenic compound — is a (CHEBI:73477)
- dicarboximide — is a (CHEBI:35356)
- organofluorine compound — is a (CHEBI:37143)
- teratogenic agent — has role (CHEBI:50905)
- herbicide — has role (CHEBI:24527)
- agrochemical — has role (CHEBI:33286)
- EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor — has role (CHEBI:73192)
- teratogenic agent — has role (CHEBI:50905)
- herbicide — has role (CHEBI:24527)
- agrochemical — has role (CHEBI:33286)
- EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor — has role (CHEBI:73192)
- benzoxazine — is a (CHEBI:46969)
- terminal acetylenic compound — is a (CHEBI:73477)
- dicarboximide — is a (CHEBI:35356)
- organofluorine compound — is a (CHEBI:37143)
Additional curated names
Cross-references from this source
- CAS: 103361-09-7 — Alan Wood's Pesticides
- CAS: 103361-09-7 — KEGG COMPOUND
- CAS: 103361-09-7 — ChemIDplus
- MANUAL_X_REF: 335 — PPDB
- MANUAL_X_REF: C11035 — KEGG COMPOUND
- MANUAL_X_REF: flumioxazin — Alan Wood's Pesticides
- MANUAL_X_REF: HMDB0034854 — HMDB
- REGISTRY_NUMBER: 8290535 — Reaxys
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-08-11. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Light tan powdered solid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellow-brown powder Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellow brown solid (technical); Light brown solid (end-use) Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.5136 g/ml @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Dissociation Constants: Does not dissociate Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 2.55 @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- LogP: 2.550 Source: Human Metabolome Database (HMDB)
- Melting Point: 201-204 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 201 - 204 °C Source: Human Metabolome Database (HMDB)
- Odor: Slight (end-use) Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Solubility: Soluble in common organic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 1.79 mg/l @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1.79 mg/L @ 25 °C (exp) Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 2.41X10-6 mm Hg @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- pH: pH= 6.2-6.4 @ 20 °C (end-use) Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H360 (35.6%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H361d (64.4%): Suspected of damaging the unborn child [Warning Reproductive toxicity]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 208 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Environmental Bioconcentration: An estimated BCF of 18 was calculated for flumioxazin(SRC), using an experimental log Kow of 2.55(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on column leaching studies and the short aerobic soil half-life, the potential for flumioxazin to leach in field agricultural soil is low(1). In soils that have been treated with flumioxazin, it is generally not found below 3 inches in depth(2). Volatilization losses from soil surfaces are negligible(1). Flumioxazin degrades rapidly in soil water via hydrolysis with half-lives of 3.4 to 5.1 days at pH 5.0, 21.4-24.6 hours at pH 7.0, and 14.6-22.0 minutes at pH 9.0(1); therefore, aqueous hydrolysis in moist soils will be an important fate process(SRC). Microbial degradation in soil is also an important fate process(1); the half-life for aerobic soil metabolism is 11.9 to 17.5 days, with an average of 14.7 days(1,2). The photolysis half-life on soil is 3.2 to 8.4 days (average 5.8 days)(2). The rapid soil dissipation rate indicates flumioxazin is not persistent in soil(1). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 13000(SRC), determined from a structure estimation method(2), indicates that flumioxazin is expected to adsorb to suspended solids and sediment(SRC). The hydrolytic degradation half-life of flumioxazin in soil water is 3.4 to 5.1 days at pH 5.0, 21.4-24.6 hours at pH 7.0, and 14.6-22.0 minutes at pH 9.0(3); therefore, hydrolysis will be the major degradation process in water(SRC). An anaerobic aquatic metabolism half-life of 0.2 days has been reported(4). The photolysis half-life in water at pH 5 is 1 day(4). Volatilization from water surfaces is expected to be slow(5) based upon an estimated Henry's Law constant of 6.28X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 2.41X10-6 mm Hg(6), and water solubility, 1.79 mg/l(4). Using this estimated Henry's Law constant and an estimation method(5), volatilization half-lives for a model river and model lake are 1,765 hours and 809 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 18(SRC), from a log Kow of 2.55(4) suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), flumioxazin, which has a vapor pressure of 2.41X10-6 mm Hg at 25 °C (2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase flumioxazin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.8 hours(SRC), calculated from its rate constant of 5.68X10-11 cu cm/molecule-sec at 25 °C(SRC) (that was derived using a structure estimation method(3). Particulate-phase flumioxazin may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Uses: For Flumioxazin (USEPA/OPP Pesticide Code: 129034) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Preemergence herbicide to effectively control a wide variety of broadleaf weeds Source: Hazardous Substances Data Bank (HSDB)
- Uses: This is a man-made compound that is used as a pesticide. Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Saudi SFDA prohibited and restricted ingredient lists
- Source reference
- SFDA prohibited list, page 74, row 4
- Source record ID
prohibited-73-4- Source version
- live-snapshot-2026-08-30
- Source language
- English
- Translation status
- Original is English
- Snapshot checked
- 2026-08-30 05:18 UTC
- Validation method
- complete SFDA paginated HTML snapshot; strict page/row counts
- SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances with CAS, EC and conditions
- Authority note
- Official SFDA dated lists; version and hash each release
How this record fits the market dataset
Status distribution
Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Saudi Arabia market context
Complete official list index
Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026
Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.
Verification checklist
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
Official market sources
- Saudi SFDA prohibited and restricted ingredient listsOfficial SFDA dated lists; version and hash each release
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Flumioxazin” and every CAS/EC identifier refer to the material in your supplier specification.
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Flumioxazin. SFDA prohibited list, page 74, row 4. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/10333/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Saudi Arabia
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: live-snapshot-2026-08-30
What it does not prove
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source