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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

Flumioxazin

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Flumioxazin
CAS
103361-09-7
EC
Not supplied in this source row
Identity mapping
standalone:official_gb_annex
Search this identity across the siteCAS 103361-09-7

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 103361-09-7
CAS 103361-09-7PubChem CID 92425

Verified chemistry for CAS 103361-09-7

Flumioxazin

IUPAC name
2-(7-fluoro-3-oxo-4-prop-2-ynyl-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydroisoindole-1,3-dione
Molecular formula
C19H15FN2O4
Molecular weight
354.3 g/mol
Exact mass
354.10158513 Da
Monoisotopic mass
354.10158513 Da
XLogP3
1.8
Topological polar surface area
66.9 Ų
Molecular complexity
724.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Rotatable bonds
2
Heavy atoms
26
Covalent units
1

Names and synonyms reported to PubChem

SumisoyaS-53482VALORS 53482V 53482EINECS Annex I Index 613-166-00-XL0PX7OGI22CHEBI:8939
16 more reported names
7-Fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2H)-one7-fluoro-6-((3,4,5,6-tetrahydro)phthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2 H)-oneV-53482n-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2h-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboxamide2-(7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2,3,4,5,6,7-hexahydro-1H-isoindole-1,3-dione2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-2,3,4,5,6,7-hexahydro-1H-isoindole-1,3-dioneRefChem:1408481H-Isoindole-1,3(2H)-dione, 2-(7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydro-Flumioxazin [ISO]Sumisoya; V 534822-[7-Fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dioneFlumioxazineFlumizinFlumioxazin Solution in Acetonitrile1H-Isoindole-1,3(2H)-dione,2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
9
3D rings
4
3D hydrophobes
1
3D acceptor features
4
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
6
Effective 3D rotors
3.6
Machine-readable structure identifiers
SMILES
C#CCN1C(=O)COC2=CC(=C(C=C21)N3C(=O)C4=C(C3=O)CCCC4)F
InChI
InChI=1S/C19H15FN2O4/c1-2-7-21-15-9-14(13(20)8-16(15)26-10-17(21)23)22-18(24)11-5-3-4-6-12(11)19(22)25/h1,8-9H,3-7,10H2
InChIKey
FOUWCSDKDDHKQP-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:8939

flumioxazin

A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops.

Formula
C19H15FN2O4
Average mass
354.337 g/mol
Monoisotopic mass
354.10159 Da
Formal charge
0
  • benzoxazine — is a (CHEBI:46969)
  • terminal acetylenic compound — is a (CHEBI:73477)
  • dicarboximide — is a (CHEBI:35356)
  • organofluorine compound — is a (CHEBI:37143)
  • teratogenic agent — has role (CHEBI:50905)
  • herbicide — has role (CHEBI:24527)
  • agrochemical — has role (CHEBI:33286)
  • EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor — has role (CHEBI:73192)
  • teratogenic agent — has role (CHEBI:50905)
  • herbicide — has role (CHEBI:24527)
  • agrochemical — has role (CHEBI:33286)
  • EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor — has role (CHEBI:73192)
  • benzoxazine — is a (CHEBI:46969)
  • terminal acetylenic compound — is a (CHEBI:73477)
  • dicarboximide — is a (CHEBI:35356)
  • organofluorine compound — is a (CHEBI:37143)
Additional curated names
2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2H)-oneN-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboxamideflumioxazineS 53482S-53482V 53482
Cross-references from this source
  • CAS: 103361-09-7 — Alan Wood's Pesticides
  • CAS: 103361-09-7 — KEGG COMPOUND
  • CAS: 103361-09-7 — ChemIDplus
  • MANUAL_X_REF: 335 — PPDB
  • MANUAL_X_REF: C11035 — KEGG COMPOUND
  • MANUAL_X_REF: flumioxazin — Alan Wood's Pesticides
  • MANUAL_X_REF: HMDB0034854 — HMDB
  • REGISTRY_NUMBER: 8290535 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-08-11. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match92425

Attributed physical-property, hazard, environmental and use annotations.

  • Environmental Bioconcentration: An estimated BCF of 18 was calculated for flumioxazin(SRC), using an experimental log Kow of 2.55(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on column leaching studies and the short aerobic soil half-life, the potential for flumioxazin to leach in field agricultural soil is low(1). In soils that have been treated with flumioxazin, it is generally not found below 3 inches in depth(2). Volatilization losses from soil surfaces are negligible(1). Flumioxazin degrades rapidly in soil water via hydrolysis with half-lives of 3.4 to 5.1 days at pH 5.0, 21.4-24.6 hours at pH 7.0, and 14.6-22.0 minutes at pH 9.0(1); therefore, aqueous hydrolysis in moist soils will be an important fate process(SRC). Microbial degradation in soil is also an important fate process(1); the half-life for aerobic soil metabolism is 11.9 to 17.5 days, with an average of 14.7 days(1,2). The photolysis half-life on soil is 3.2 to 8.4 days (average 5.8 days)(2). The rapid soil dissipation rate indicates flumioxazin is not persistent in soil(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 13000(SRC), determined from a structure estimation method(2), indicates that flumioxazin is expected to adsorb to suspended solids and sediment(SRC). The hydrolytic degradation half-life of flumioxazin in soil water is 3.4 to 5.1 days at pH 5.0, 21.4-24.6 hours at pH 7.0, and 14.6-22.0 minutes at pH 9.0(3); therefore, hydrolysis will be the major degradation process in water(SRC). An anaerobic aquatic metabolism half-life of 0.2 days has been reported(4). The photolysis half-life in water at pH 5 is 1 day(4). Volatilization from water surfaces is expected to be slow(5) based upon an estimated Henry's Law constant of 6.28X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 2.41X10-6 mm Hg(6), and water solubility, 1.79 mg/l(4). Using this estimated Henry's Law constant and an estimation method(5), volatilization half-lives for a model river and model lake are 1,765 hours and 809 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 18(SRC), from a log Kow of 2.55(4) suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), flumioxazin, which has a vapor pressure of 2.41X10-6 mm Hg at 25 °C (2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase flumioxazin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.8 hours(SRC), calculated from its rate constant of 5.68X10-11 cu cm/molecule-sec at 25 °C(SRC) (that was derived using a structure estimation method(3). Particulate-phase flumioxazin may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 736
Source record ID
II-736
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Flumioxazin” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 736, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Flumioxazin. GB Cosmetics Regulation, Annex II, entry 736. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/5091/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source