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ProhibitedBinding ruleKRNo English translationOfficial-source import checked

니켈 설파이드

Listed by the Korean MFDS as a substance that may not be used in cosmetics.

All South Korea recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
니켈 설파이드
CAS
16812-54-7; 11113-75-0; 1314-04-1
EC
Not supplied in this source row
Identity mapping
standalone:official_korean_name
Search this identity across the siteCAS 16812-54-7CAS 11113-75-0CAS 1314-04-1

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 11113-75-0
CAS 11113-75-0PubChem CID 166709

Verified chemistry for CAS 11113-75-0

Nickel Sulfide

IUPAC name
nickel(2+) sulfide
Molecular formula
NiS
Molecular weight
90.76 g/mol
Exact mass
89.907413 Da
Monoisotopic mass
89.907413 Da
Topological polar surface area
1.0 Ų
Molecular complexity
0.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
2
Covalent units
2

Names and synonyms reported to PubChem

Nickel monosulfideNickelous sulfideI6929D52YQRefChem:165683234-349-7240-841-2beta Nickel sulfideMononickel monosulfide
7 more reported names
Nickel sulfide crystalline particlessulfanylidenenickelnickel(2+);sulfideNickel sulfide (Ni7S6)Heptanickel hexasulpideADGNAMGSVYAHHD-UHFFFAOYSA-Nnickel (II) sulfide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[S-2].[Ni+2]
InChI
InChI=1S/Ni.S/q+2;-2
InChIKey
ADGNAMGSVYAHHD-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match166709

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
  • Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1314-04-1
CAS 1314-04-1PubChem CID 28094

Verified chemistry for CAS 1314-04-1

Nickel sulfide (NiS)

IUPAC name
sulfanylidenenickel
Molecular formula
NiS
Molecular weight
90.76 g/mol
Exact mass
89.907413 Da
Monoisotopic mass
89.907413 Da
Topological polar surface area
32.1 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
2
Covalent units
1

Names and synonyms reported to PubChem

Nickel(II)sulfideNickel sulfide (millerite)MilleriteCCRIS 3733EINECS 234-349-7Nickel sulfide (amorphous)alpha-Nickel sulfide (1:1) crystallineUNII-I6929D52YQ
7 more reported names
CCRIS 6428(Sulfido)nickelMillerite (NiS)EINECS 240-841-2Nickel sulfide(ous)CS-0110975EC 240-841-2
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
S=[Ni]
InChI
InChI=1S/Ni.S
InChIKey
WWNBZGLDODTKEM-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16812-54-7
CAS 16812-54-7PubChem CID 28094

Verified chemistry for CAS 16812-54-7

Nickel sulfide (NiS)

IUPAC name
sulfanylidenenickel
Molecular formula
NiS
Molecular weight
90.76 g/mol
Exact mass
89.907413 Da
Monoisotopic mass
89.907413 Da
Topological polar surface area
32.1 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
2
Covalent units
1

Names and synonyms reported to PubChem

Nickel(II)sulfideNickel sulfide (millerite)1314-04-1MilleriteCCRIS 3733EINECS 234-349-7Nickel sulfide (amorphous)alpha-Nickel sulfide (1:1) crystalline
8 more reported names
UNII-I6929D52YQCCRIS 6428(Sulfido)nickelMillerite (NiS)EINECS 240-841-2Nickel sulfide(ous)CS-0110975EC 240-841-2
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
S=[Ni]
InChI
InChI=1S/Ni.S
InChIKey
WWNBZGLDODTKEM-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
South Korea MFDS cosmetic ingredient data
Source reference
화장품 안전기준 등에 관한 규정, 별표 1, record 1-50
Source record ID
1-50
Source version
2026-19
Source language
Korean
Translation status
No English translation
Effective date
2026-03-18
Source updated
2026-03-18
Snapshot checked
2026-08-30 04:33 UTC
Validation method
MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8

Registered dataset notes

Dataset coverage
Ingredient identity and separate restriction/regulation data endpoints
Authority note
Korean source is canonical; English materials alone are not complete enough for certification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1320
current South Korea records
1077
records marked Prohibited
1320
records from this source version
1252
market records with CAS identity

Status distribution

Prohibited: 1077Restricted: 243

Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

South Korea market context

Complete current appendix dataset

Coverage version: MFDS Notice 2026-19, effective 18 March 2026

All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.

Verification checklist

  1. Match the Korean canonical substance name and identifiers.
  2. Review all Appendix 1 and 2 matches and conditions.
  3. Check functional-cosmetic and positive-list requirements where applicable.
  4. Confirm current MFDS notice, responsible seller and label obligations.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “니켈 설파이드” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Match the Korean canonical substance name and identifiers.
  3. Review all Appendix 1 and 2 matches and conditions.
  4. Check functional-cosmetic and positive-list requirements where applicable.
  5. Confirm current MFDS notice, responsible seller and label obligations.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

The record cites 화장품 안전기준 등에 관한 규정, 별표 1, record 1-50, source version 2026-19. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

니켈 설파이드. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-50. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/848/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for South Korea

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-19
  • Effective date: 2026-03-18

What it does not prove

Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source