ProhibitedBinding ruleKRNo English translationOfficial-source import checked
트리니켈디설파이드
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- Listed by the Korean MFDS as a substance that may not be used in cosmetics.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 트리니켈디설파이드
- CAS
- 12035-72-2
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_korean_name
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
Prohibited entry found
1 linked record
Open supporting recordGreat Britain
Prohibited
1 linked record
Open supporting recordNew Zealand
Prohibited
1 linked record
Open supporting recordASEAN
Prohibited
1 linked record
Open supporting recordChina
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
Current recordProhibited
1 linked record
Open supporting recordBrazil
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordIndia
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
Prohibited
1 linked record
Open supporting recordCAS 12035-72-2PubChem CID 25199732
Verified chemistry for CAS 12035-72-2
NICKEL SULFIDE (Ni3S2)
- IUPAC name
- nickel;sulfanylidenenickel
- Molecular formula
- Ni3S2
- Molecular weight
- 240.22 g/mol
- Exact mass
- 239.745611 Da
- Monoisotopic mass
- 237.75017 Da
- Topological polar surface area
- 64.2 Ų
- Molecular complexity
- 2.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 5
- Covalent units
- 3
Names and synonyms reported to PubChem
RefChem:927714CHEBI:144804234-829-6alpha nickel subsulfidealpha-Nickel sulfide (3:2) crystallinedisulfanylidenetrinickelNi3S2Nickel sesquisulfide
12 more reported names
Nickel Subsulfidenickel subsulfide (Ni3S2)Nickel subsulphideNickel sulfide (3:2)Nickel tritadisulphideNickel(III) sulfideTrinickel disulfideZK2A2WV92ZHeazlewooditeKhizlevuditealpha-Nickel subsulfideCCRIS 7580
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
S=[Ni].S=[Ni].[Ni]- InChI
InChI=1S/3Ni.2S- InChIKey
YGHCWPXPAHSSNA-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match25199732
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Hexagonal crystals Source: Hazardous Substances Data Bank (HSDB)
- Density: 5.82 (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 5.87 Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 5.82 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 1454 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 787 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 790 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Nickel subsulfide appears as pale yellowish-bronze metallic-lustrous crystals or shiny gold-green (metallic) crystalline powder. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Large Crystals; CBI; Wet Solid; Other Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Yellowish-bronze to gold-green metallic solid; [CAMEO] Slightly soluble in water; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: PALE YELLOWISH BRONZE LUMPS WITH METALLIC LUSTRE. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: less than 1 mg/mL at 70.7 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: INSOL IN COLD WATER; SOL IN NITRIC ACID Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water, mg/l at 37 °C: 517 (practically insoluble) Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Substance: Nickel Subsulfide Source: NTP Technical Reports
- NTP Technical Report: TR-453: Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1996 ) Source: NTP Technical Reports
- Peer Review Date: 11/29/94 Source: NTP Technical Reports
- Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
- Summary: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of nickel subsulfide in male F344/N rats based on increased incidences of alveolar/bronchiolar adenoma, carcinoma, and adenoma or carcinoma (combined) and on increased incidences of benign, malignant, and benign or malignant (combined) pheochromocytoma of the adrenal medulla. There was clear evidence of carcinogenic activity of nickel subsulfide in female F344/N rats based on increased incidences of alveolar/bronchiolar carcinoma and alveolar/bronchiolar adenoma or carcinoma (combined) and an increased incidence of benign pheochromocytoma of the adrenal medulla. There was no evidence of carcinogenic activity of nickel subsulfide in male or female B6C3F1 mice exposed to 0.6 or 1.2 mg/m3.; Exposure of male and female rats to nickel subsulfide by inhalation for 2 years resulted in inflammation, hyperplasia, and fibrosis in the lung; inflammation and atrophy of the olfactory epithelium in the nose; and hyperplasia in the adrenal medulla (females). Exposure of male and female mice to nickel subsulfide by inhalation for 2 years resulted in inflammation, bronchialization, hyperplasia Source: NTP Technical Reports
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: Inhalation (L41) ; oral (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P272, P273, P280, P302+P352, P304+P340, P316, P318, P319, P321, P333+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P302+P352, P304+P340, P308+P316, P316, P318, P319, P321, P333+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350: May cause cancer [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: ... Respiratory absorption with secondary gastrointestinal absorption of nickel (insoluble & soluble cmpd) is the major route of entry during occupational exposure. A significant quantity of inhaled material is swallowed following mucocillary clearance from the respiratory tract. Poor personal hygiene & work practices can contribute to gastrointestinal exposure. Percutaneous absorption is negligible, quantitatively, but is important in the pathogenesis of contact hypersensitivity. Absorption is related to the solubility of the cmpd, following the general relationships nickel carbonyl> soluble nickel cmpd> insoluble nickel cmpd. ... Long term inhalation exposure to ... nickel subsulfide caused mucosal damage & infalmmatory reaction in the respiratory tract in rats, mice & guinea pigs. ... Pulmonary fibrosis was seen in rats exposed to nickel subsulfide. In an inhalation study, nickel subsulfide induced benign & malignant pulmonary tumors in rats. ... Nickel subsulfide ... induced local mesenchymal tumors in a variety of experimental animals after im, sc, ip, intrapleural, intraocular, introsseous, intrarenal, intra-articular, intratesticular or intra-adipose admin. ... Nickel subsul Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
- Environmental Fate: IT IS NOT BELIEVED TO BE SIGNIFICANT ATMOSPHERIC OR WATER POLLUTANT. Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Intermediates; Other; Not Known or Reasonably Ascertainable; Catalyst; Intermediate Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable; Catalyst; Intermediate; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used in lithium primary batteries; [HSDB] Formed in smelting and refining of nickel ores and may be formed when nickel catalysts are used in petroleum refining; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Battery Manufacturing [Category: Industry]; Metal Extraction and Refining [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: In lithium primary batteries Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- South Korea MFDS cosmetic ingredient data
- Source reference
- 화장품 안전기준 등에 관한 규정, 별표 1, record 1-1013
- Source record ID
1-1013- Source version
- 2026-19
- Source language
- Korean
- Translation status
- No English translation
- Effective date
- 2026-03-18
- Source updated
- 2026-03-18
- Snapshot checked
- 2026-08-30 04:33 UTC
- Validation method
- MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
- SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8
Registered dataset notes
- Dataset coverage
- Ingredient identity and separate restriction/regulation data endpoints
- Authority note
- Korean source is canonical; English materials alone are not complete enough for certification
How this record fits the market dataset
1320
current South Korea records
1077
records marked Prohibited
1320
records from this source version
1252
market records with CAS identity
Status distribution
Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
South Korea market context
Complete current appendix dataset
Coverage version: MFDS Notice 2026-19, effective 18 March 2026
All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.
Verification checklist
- Match the Korean canonical substance name and identifiers.
- Review all Appendix 1 and 2 matches and conditions.
- Check functional-cosmetic and positive-list requirements where applicable.
- Confirm current MFDS notice, responsible seller and label obligations.
Official market sources
- South Korea MFDS cosmetic ingredient dataKorean source is canonical; English materials alone are not complete enough for certification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “트리니켈디설파이드” and every CAS/EC identifier refer to the material in your supplier specification.
- Match the Korean canonical substance name and identifiers.
- Review all Appendix 1 and 2 matches and conditions.
- Check functional-cosmetic and positive-list requirements where applicable.
- Confirm current MFDS notice, responsible seller and label obligations.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
The record cites 화장품 안전기준 등에 관한 규정, 별표 1, record 1-1013, source version 2026-19. Open the official source.
No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.
Stable citation
트리니켈디설파이드. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-1013. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/1655/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for South Korea
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: 2026-19
- Effective date: 2026-03-18
What it does not prove
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source