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ProhibitedBinding ruleKRNo English translationOfficial-source import checked

아다팔렌

Listed by the Korean MFDS as a substance that may not be used in cosmetics.

All South Korea recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
아다팔렌
CAS
106685-40-9
EC
Not supplied in this source row
Identity mapping
standalone:official_korean_name
Search this identity across the siteCAS 106685-40-9

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

1 market dataset
PubChem 2D chemical structure for CAS 106685-40-9
CAS 106685-40-9PubChem CID 60164

Verified chemistry for CAS 106685-40-9

Adapalene

IUPAC name
6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
Molecular formula
C28H28O3
Molecular weight
412.5 g/mol
Exact mass
412.20384475 Da
Monoisotopic mass
412.20384475 Da
XLogP3
7.7
Topological polar surface area
46.5 Ų
Molecular complexity
644.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
31
Covalent units
1

Names and synonyms reported to PubChem

DifferinAdaferinAdapalenoCD-271AdapalenumDifferineCD 2716-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
16 more reported names
CD2716-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid1L4806J2QF6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acidIDP-126 Component AdapaleneCHEBI:31174CABTREO COMPONENT ADAPALENE2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo(3.3.1.1(sup 3,7))dec-1-ylphenyl)-AdaplaeneEffaclarAdapalene Gel6-(3-(adamantan-1-yl)-4-methoxyphenyl)naphthalene-2-carboxylic acidProactiv MD Kit6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic AcidCurist Acne Relief
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
11
3D rings
7
3D hydrophobes
0
3D acceptor features
3
3D donor features
0
3D anionic centres
1
3D cationic centres
0
3D conformers
6
Effective 3D rotors
5.2
Machine-readable structure identifiers
SMILES
COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
InChI
InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
InChIKey
LZCDAPDGXCYOEH-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:31174

adapalene

A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.

Formula
C28H28O3
Average mass
412.529 g/mol
Monoisotopic mass
412.20384 Da
Formal charge
0
  • naphthoic acid — is a (CHEBI:25483)
  • monocarboxylic acid — is a (CHEBI:25384)
  • adamantanes — is a (CHEBI:51339)
  • dermatologic drug — has role (CHEBI:50177)
  • non-steroidal anti-inflammatory drug — has role (CHEBI:35475)
  • EC 2.7.11.22 (cyclin-dependent kinase) inhibitor — has role (CHEBI:82665)
  • CD437 — has functional parent (CHEBI:88334)
  • dermatologic drug — has role (CHEBI:50177)
  • non-steroidal anti-inflammatory drug — has role (CHEBI:35475)
  • EC 2.7.11.22 (cyclin-dependent kinase) inhibitor — has role (CHEBI:82665)
  • naphthoic acid — is a (CHEBI:25483)
  • monocarboxylic acid — is a (CHEBI:25384)
  • adamantanes — is a (CHEBI:51339)
Additional curated names
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acidCD 271CD-271
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match60164

Attributed physical-property, hazard, environmental and use annotations.

  • Exposure Routes: Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials Source: Toxin and Toxin Target Database (T3DB)
  • Note: This chemical does not meet GHS hazard criteria for 9.1% (1 of 11) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (18.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (72.7%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (54.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (72.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (18.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361 (81.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 11 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 11 reports by companies.; There are 6 notifications provided by 10 of 11 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: If the adapalene is applied excessively, marked redness, scaling, or skin discomfort may occur. In addition, according to product labeling, chronic ingestion of the drug may lead to the same adverse drug reactions associated with excessive oral intake of vitamin A. Source: StatPearls
  • Toxicity Summary: Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Source: Toxin and Toxin Target Database (T3DB)
  • Uses: Use (kg) in USA (2002): 78; Consumption (g per capita) in the USA (2002): 0.000278; Calculated removal (%): 97.7 Source: NORMAN Suspect List Exchange
  • Uses: For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
South Korea MFDS cosmetic ingredient data
Source reference
화장품 안전기준 등에 관한 규정, 별표 1, record 1-571
Source record ID
1-571
Source version
2026-19
Source language
Korean
Translation status
No English translation
Effective date
2026-03-18
Source updated
2026-03-18
Snapshot checked
2026-08-30 04:33 UTC
Validation method
MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8

Registered dataset notes

Dataset coverage
Ingredient identity and separate restriction/regulation data endpoints
Authority note
Korean source is canonical; English materials alone are not complete enough for certification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1320
current South Korea records
1077
records marked Prohibited
1320
records from this source version
1252
market records with CAS identity

Status distribution

Prohibited: 1077Restricted: 243

Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

South Korea market context

Complete current appendix dataset

Coverage version: MFDS Notice 2026-19, effective 18 March 2026

All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.

Verification checklist

  1. Match the Korean canonical substance name and identifiers.
  2. Review all Appendix 1 and 2 matches and conditions.
  3. Check functional-cosmetic and positive-list requirements where applicable.
  4. Confirm current MFDS notice, responsible seller and label obligations.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “아다팔렌” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Match the Korean canonical substance name and identifiers.
  3. Review all Appendix 1 and 2 matches and conditions.
  4. Check functional-cosmetic and positive-list requirements where applicable.
  5. Confirm current MFDS notice, responsible seller and label obligations.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

The record cites 화장품 안전기준 등에 관한 규정, 별표 1, record 1-571, source version 2026-19. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

아다팔렌. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-571. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/1297/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for South Korea

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-19
  • Effective date: 2026-03-18

What it does not prove

Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source