CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
CAS 0 records

CAS 106685-40-9

CAS 106685-40-9 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

Check this CAS numberBrowse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 106685-40-9
CAS 106685-40-9PubChem CID 60164

Adapalene

IUPAC name
6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
Molecular formula
C28H28O3
Molecular weight
412.5 g/mol
Exact mass
412.20384475 Da
XLogP3
7.7
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

DifferinAdaferinAdapalenoCD-271AdapalenumDifferineCD 2716-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
16 more reported names
CD2716-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid1L4806J2QF6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acidIDP-126 Component AdapaleneCHEBI:31174CABTREO COMPONENT ADAPALENE2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo(3.3.1.1(sup 3,7))dec-1-ylphenyl)-AdaplaeneEffaclarAdapalene Gel6-(3-(adamantan-1-yl)-4-methoxyphenyl)naphthalene-2-carboxylic acidProactiv MD Kit6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic AcidCurist Acne Relief
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:31174

adapalene

A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.

Formula
C28H28O3
Average mass
412.529 g/mol
Monoisotopic mass
412.20384 Da
Formal charge
0
  • naphthoic acid — is a (CHEBI:25483)
  • monocarboxylic acid — is a (CHEBI:25384)
  • adamantanes — is a (CHEBI:51339)
  • dermatologic drug — has role (CHEBI:50177)
  • non-steroidal anti-inflammatory drug — has role (CHEBI:35475)
  • EC 2.7.11.22 (cyclin-dependent kinase) inhibitor — has role (CHEBI:82665)
  • CD437 — has functional parent (CHEBI:88334)
  • dermatologic drug — has role (CHEBI:50177)
  • non-steroidal anti-inflammatory drug — has role (CHEBI:35475)
  • EC 2.7.11.22 (cyclin-dependent kinase) inhibitor — has role (CHEBI:82665)
  • naphthoic acid — is a (CHEBI:25483)
  • monocarboxylic acid — is a (CHEBI:25384)
  • adamantanes — is a (CHEBI:51339)
Additional curated names
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acidCD 271CD-271
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match60164

Attributed physical-property, hazard, environmental and use annotations.

  • Exposure Routes: Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials Source: Toxin and Toxin Target Database (T3DB)
  • Note: This chemical does not meet GHS hazard criteria for 9.1% (1 of 11) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (18.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (72.7%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (54.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (72.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (18.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361 (81.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 11 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 11 reports by companies.; There are 6 notifications provided by 10 of 11 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: If the adapalene is applied excessively, marked redness, scaling, or skin discomfort may occur. In addition, according to product labeling, chronic ingestion of the drug may lead to the same adverse drug reactions associated with excessive oral intake of vitamin A. Source: StatPearls
  • Toxicity Summary: Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Source: Toxin and Toxin Target Database (T3DB)
  • Uses: Use (kg) in USA (2002): 78; Consumption (g per capita) in the USA (2002): 0.000278; Calculated removal (%): 97.7 Source: NORMAN Suspect List Exchange
  • Uses: For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 106685-40-9

0 total
No records found for this CAS number.

How CAS 106685-40-9 is used on this site

CAS 106685-40-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 106685-40-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.