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RestrictedBinding ruleJPRegulator-hosted provisional English translationOfficial-source import checked

Cinoxate

Japan Standards for Cosmetics: Cinoxate

The provisional English translation of the MHLW Standards for Cosmetics lists this ingredient with the stated limit or use matrix.

All Japan recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
The provisional English translation of the MHLW Standards for Cosmetics lists this ingredient with the stated limit or use matrix.
Conditions and restrictions
Published three-column use matrix (rinse-off / leave-on / mucosal; blank means prohibited, ○ means no upper limit): ○ 5.0 5.0

Substance identity

Official source name
Cinoxate
CAS
104-28-9
EC
203-191-0
Identity mapping
exact INCI name
Linked ingredient
CINOXATE
Search this identity across the siteCAS 104-28-9EC 203-191-0

Linked CosIng identity data

Names and aliases

CINOXATEcinoxate

CosIng description: 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester

Recorded cosmetic function: UV ABSORBER

Function pages:UV ABSORBER

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

3 market datasets
PubChem 2D chemical structure for CAS 104-28-9
CAS 104-28-9PubChem CID 5373773

Verified chemistry for CAS 104-28-9

Cinoxate

IUPAC name
2-ethoxyethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
Molecular formula
C14H18O4
Molecular weight
250.29 g/mol
Exact mass
250.12050905 Da
Monoisotopic mass
250.12050905 Da
XLogP3
2.4
Topological polar surface area
44.8 Ų
Molecular complexity
255.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
8
Heavy atoms
18
Covalent units
1

Names and synonyms reported to PubChem

PhiasolSundareGive-TanCinoxatoGiv Tan F2-ETHOXYETHYL P-METHOXYCINNAMATECinoxatum2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester
16 more reported names
2-Ethoxyethyl-p-methoxycinnamate3-(4-Methoxyphenyl)-2-propenoic acid 2-ethoxyethyl ester5437O7N5BHCinnamic acid, p-methoxy-, 2-ethoxyethyl ester2-ethoxyethyl (2E)-3-(4-methoxyphenyl)prop-2-enoateRefChem:577241203-191-0Giv-tan F2-ethoxyethyl 3-(4-methoxyphenyl)prop-2-enoatePropenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl esterGiv TanfCaswell No. 427ECinoxatum [INN-Latin]Cinoxato [INN-Spanish]CCRIS 4813HSDB 7424
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
1
3D hydrophobes
0
3D acceptor features
3
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
8.0
Machine-readable structure identifiers
SMILES
CCOCCOC(=O)/C=C/C1=CC=C(C=C1)OC
InChI
InChI=1S/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3/b9-6+
InChIKey
CMDKPGRTAQVGFQ-RMKNXTFCSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5373773

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Environmental Bioconcentration: An estimated BCF of 26 was calculated for cinoxate in fish(SRC), using an estimated log Kow of 2.65(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 208(SRC), determined from a structure estimation method(2), indicates that cinoxate is expected to have moderate mobility in soil(SRC). Volatilization of cinoxate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.1X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Cinoxate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.6X10-5 mm Hg(SRC), determined from a fragment constant method(2). Cinoxate absorbs UV light in the sunlight spectrum(3) and, therefore, may be susceptible to direct photolysis on soil surfaces exposed to sunlight(SRC). No relevant data were available to assess the importance of biodegradation in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 208(SRC), determined from a structure estimation method(2), indicates that cinoxate may have some moderate adsorption to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.1X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(1). According to a classification scheme(4), an estimated BCF of 26(SRC), from an estimated log Kow of 2.65(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low (SRC). A base-catalyzed second-order hydrolysis rate constant of 2.5X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 8.9 and 0.89 years at pH values of 7 and 8, respectively(2). Cinoxate absorbs UV light in the sunlight spectrum(5) and, therefore, may be susceptible to direct photolysis on water surfaces exposed to sunlight(SRC). No relevant data were available to assess the importance of biodegradation in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cinoxate, which has an estimated vapor pressure of 1.6X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase cinoxate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.7 hours(SRC), calculated from its rate constant of 5.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase cinoxate is also degraded in the atmosphere by reaction with ozone (SRC); the half-life for this reaction in air is estimated to be about 19 hours(SRC), calculated from its rate constant of 1.6X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase cinoxate may be removed from the air by wet and dry deposition(SRC). Cinoxate absorbs UV light in the sunlight spectrum(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Japan MHLW Standards for Cosmetics
Source reference
Appendix 4 section 2, entry 5
Source record ID
appendix-4-2:5
Source version
MHLW Notification No. 331 provisional translation, retrieved 2026-08-30
Source language
English provisional translation; Japanese text is canonical
Translation status
Regulator-hosted provisional English translation · English translation
Snapshot checked
2026-08-30 04:11 UTC
Validation method
pdftotext -layout plus strict per-table row counts
SHA-256
117fc949a82789ca66017163f19041cf2fcf6b5902708077c8e4f56c482dc8e2

Registered dataset notes

Dataset coverage
Prohibited and restricted ingredient appendices with concentration and use conditions
Authority note
Official MHLW standard; validate later Japanese updates before presenting current status
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

117
current Japan records
87
records marked Restricted
117
records from this source version
32
market records with CAS identity

Status distribution

Prohibited: 30Restricted: 87

Condition text is present on 117 of 117 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Japan market context

Complete Standards appendices dataset

Coverage version: MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot

Prohibited ingredients, restricted ingredients and permitted preservative/UV/colourant appendices present in the official standard source.

Verification checklist

  1. Search Japanese/English identity and CAS where present.
  2. Apply category and maximum-amount conditions.
  3. Check later MHLW notices against the Japanese source.
  4. Verify marketing licence, notification, labelling and quasi-drug classification.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Cinoxate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search Japanese/English identity and CAS where present.
  3. Apply category and maximum-amount conditions.
  4. Check later MHLW notices against the Japanese source.
  5. Verify marketing licence, notification, labelling and quasi-drug classification.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.

The record cites Appendix 4 section 2, entry 5, source version MHLW Notification No. 331 provisional translation, retrieved 2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Cinoxate. Appendix 4 section 2, entry 5. Japan. Source version MHLW Notification No. 331 provisional translation, retrieved 2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/jp/records/692/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Japan

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: MHLW Notification No. 331 provisional translation, retrieved 2026-08-30

What it does not prove

The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source