CINOXATE
2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester
CINOXATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Source mapped Inventory entry; no linked annex rule | 0 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Evidence linked Permitted list with conditions Open this evidence | 1 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Evidence linked Restricted Open this evidence | 1 | Japanese; official English translation available |
| South Korea | Evidence linked Restricted Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Source mapped Official source mapped; ingredient rule not imported | 0 | Arabic and English |
Chemical identity and properties
Cinoxate
2-ethoxyethyl-p-methoxycinnamate is a viscous clear to pale yellow liquid. Insoluble in water. (NTP, 1992) — CAMEO Chemicals
- IUPAC name
- 2-ethoxyethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
- Molecular formula
- C14H18O4
- Molecular weight
- 250.29 g/mol
- Exact mass
- 250.12050905 Da
- XLogP3
- 2.4
- Topological polar surface area
- 44.8 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL2104045
- EPA DTXSID:DTXSID101167513
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 388 °C at 760 mm Hg /Extrapolated from 185 °C at 2 mm Hg/ Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: BP: 185 °C at 2 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Viscous liquid, may have slight yellow tinge Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.1000 to 1.1035 at 77 °F (NTP, 1992) Source: CAMEO Chemicals
- Density: 1.102 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: greater than 212 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: Solidifies below -25 °C Source: Hazardous Substances Data Bank (HSDB)
- Odor: Practically odorless Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 2-ethoxyethyl-p-methoxycinnamate is a viscous clear to pale yellow liquid. Insoluble in water. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Viscous liquid; May be slightly yellow; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Refractive Index: Index of refraction: 1.567 at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Insoluble (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Practically insoluble in water with a solubility of approximately 0.05%. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in glycerol 0.5%, propolyene glycol 5%; miscible with alcohols and vegetable oils Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.00034 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Environmental Bioconcentration: An estimated BCF of 26 was calculated for cinoxate in fish(SRC), using an estimated log Kow of 2.65(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 208(SRC), determined from a structure estimation method(2), indicates that cinoxate is expected to have moderate mobility in soil(SRC). Volatilization of cinoxate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.1X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Cinoxate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.6X10-5 mm Hg(SRC), determined from a fragment constant method(2). Cinoxate absorbs UV light in the sunlight spectrum(3) and, therefore, may be susceptible to direct photolysis on soil surfaces exposed to sunlight(SRC). No relevant data were available to assess the importance of biodegradation in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 208(SRC), determined from a structure estimation method(2), indicates that cinoxate may have some moderate adsorption to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.1X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(1). According to a classification scheme(4), an estimated BCF of 26(SRC), from an estimated log Kow of 2.65(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low (SRC). A base-catalyzed second-order hydrolysis rate constant of 2.5X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 8.9 and 0.89 years at pH values of 7 and 8, respectively(2). Cinoxate absorbs UV light in the sunlight spectrum(5) and, therefore, may be susceptible to direct photolysis on water surfaces exposed to sunlight(SRC). No relevant data were available to assess the importance of biodegradation in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cinoxate, which has an estimated vapor pressure of 1.6X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase cinoxate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.7 hours(SRC), calculated from its rate constant of 5.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase cinoxate is also degraded in the atmosphere by reaction with ozone (SRC); the half-life for this reaction in air is estimated to be about 19 hours(SRC), calculated from its rate constant of 1.6X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase cinoxate may be removed from the air by wet and dry deposition(SRC). Cinoxate absorbs UV light in the sunlight spectrum(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as ultraviolet screen; [Merck Index] The cinnamates are a group of chemically related substances that are used as fragrances and flavorings and less frequently as sunscreens. [Marks, p. 219] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For cinoxate (USEPA/OPP Pesticide Code: 076604) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: The active ingredient is no longer contained in any registered products ... "cancelled." Source: Hazardous Substances Data Bank (HSDB)
- Uses: Ultraviolet screen Source: Hazardous Substances Data Bank (HSDB)
- Uses: Sunscreening Agents Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for CINOXATE
INCI name
CINOXATE
INN name
cinoxate
Description
2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester
Record provenance
- Inventory reference
- 32854
- Imported identity
- CINOXATE
- Source update
- 15/10/2010
Annex records for CINOXATE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
The 3 markets that hold a rule for this substance do not classify it the same way.
- restricted
- JapanSouth Korea
- permitted on a positive list
- New Zealand
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How CINOXATE appears in the CosIng inventory
The CosIng inventory lists CINOXATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
CINOXATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for CINOXATE
This page reproduces the CosIng inventory entry for CINOXATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research CINOXATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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