CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
RestrictedBinding ruleINOriginal is EnglishOfficial-source import checked

Benzyl benzoate (CAS No. 120-51-4)

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

All India recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.
Conditions and restrictions
Other limitations/requirements: The presence of the substance must be indicated in the list of ingredients when its concentration exceeds: a)0.001 percent in leave on products and b)0.001 percent in rinse off products.

Substance identity

Official source name
Benzyl benzoate (CAS No. 120-51-4)
CAS
120-51-4
EC
204-402-9
Identity mapping
cas_number
Linked ingredient
BENZYL BENZOATE
Search this identity across the siteCAS 120-51-4EC 204-402-9

Linked CosIng identity data

Names and aliases

BENZYL BENZOATEBenzylis benzoas

CosIng description: Benzyl benzoate; Phenylmethyl benzoate

EU inventory restriction note: III/85

Recorded cosmetic function: ANTIMICROBIAL, PERFUMING, SOLVENT

Function pages:ANTIMICROBIAL, PERFUMING, SOLVENT

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets
PubChem 2D chemical structure for CAS 120-51-4
CAS 120-51-4PubChem CID 2345

Verified chemistry for CAS 120-51-4

Benzyl Benzoate

IUPAC name
benzyl benzoate
Molecular formula
C14H12O2
Molecular weight
212.24 g/mol
Exact mass
212.083729621 Da
Monoisotopic mass
212.083729621 Da
XLogP3
4.0
Topological polar surface area
26.3 Ų
Molecular complexity
213.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
4
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

AscabiolBenylateBenzoic acid, phenylmethyl esterPhenylmethyl benzoateBenzoic acid, benzyl esterScobenolAscabinNovoscabin
16 more reported names
ScabiozonBenzyl phenylformateBenzyletsColebenzPeruscabinScabancaScabagenScabitoxVanzoateVenzonateScabideBenzyl benzenecarboxylateAntiscabiosumBenzylis benzoasBenzyl alcohol benzoic esterPeruscabina
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2
InChI
InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2
InChIKey
SESFRYSPDFLNCH-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match2345

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H400 (21.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (99.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2822 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P270, P273, P308+P316, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: NITE-CMC
  • Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Benzyl benzoate is a liquid. It is used as solvent of cellulose acetate, nitrocellulose and artificial musk, substitute for camphor in celluloid and plastic pyroxylin compounds, perfume fixative, in confectionary and chewing gum flavors. As an insecticide/miticide, it was used to control dust mites in carpets, mattresses, upholstery, and on furniture. Benzyl benzoate is used as an alternative agent for the topical treatment of scabies and also has been used for the topical treatment of pediculosis (lice infestation). It is also used in veterinary medicine as acaricide and pediculicide, but is contraindicated in cats. It was used in the Vietnam War to eradicate and repel certain ticks and mites. HUMAN STUDIES: Direct contact may cause skin irritation. Liquid is irritating to eyes on direct contact, but no damage has been reported. There was no evidence of adverse effects on pregnancy outcome due to topical benzyl benzoate lotion. Benzyl benzoate gave estrogenic responses in a human breast cancer cell line in culture. ANIMAL STUDIES: 13-week study in rats demonstrated decreased body weight gain and mortality at 800 mg/kg/day. Neurotoxicity signs noted such as Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 190 was calculated in fish for benzyl benzoate(SRC), using a log Kow of 3.97(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2500(SRC), determined from a structure estimation method(2), indicates that benzyl benzoate is expected to have slight mobility in soil(SRC). Volatilization of benzyl benzoate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.3X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Benzyl benzoate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.24X10-4 mm Hg at 25 °C(3). Utilizing the Japanese MITI test, 90% of the Theoretical BOD was reached in 4 weeks(4) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2500(SRC), determined from a structure estimation method(2), indicates that benzyl benzoate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 190(SRC), from its log Kow of 3.97(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Hydrolysis is not expected to be an important environmental fate process as suggested by estimated acid-base hydrolysis half-lives of 1.7 years and 63 days at pH 7 and pH 8, respectively(1). Utilizing the Japanese MITI test, 90% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyl benzoate, which has a vapor pressure of 2.25X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase benzyl benzoate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 55 hrs(SRC), calculated from its rate constant of 7.0X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase benzyl benzoate may be removed from the air by wet and dry deposition(SRC). Benzyl benzoate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: Benzyl Benzoate Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used in plastic pyroxylin compounds, flavors, perfumes, plasticizers, dye carriers, antispasmodic drugs, insect repellants, scabicides , and pediculicides; [HSDB] Used as a dye carrier and a solvent for cellulose derivatives, plasticizers, and perfume fixatives; It is the main constituent in Peru balsam; Used in drugs for asthma; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For benzyl benzoate (USEPA/OPP Pesticide Code: 009501) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: As solvent of cellulose acetate, nitrocellulose and artificual musk; substitute for camphor in celluloid and plastic pyroxylin compounds; perfume fixative; in confectionary and chewing gum flavors. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Fixative and solvent for musk in perfumes and flavors; medicine (external); plasticizer for nitrocellulose and cellulose acetate, miticide. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Reported uses (ppm):; Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#818] Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for Benzyl benzoate (8 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use (kg; approx.) in Germany (2009): >750; Consumption (g per capita; approx.) in Germany (2009): 0.00916; Excretion rate: 1; Calculated removal (%): 94.9 Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex B, entry 82
Source record ID
annex-b:82
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
317
records marked Restricted
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Benzyl benzoate (CAS No. 120-51-4)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex B, entry 82, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Benzyl benzoate (CAS No. 120-51-4). IS 4707 (Part 2):2025 Annex B, entry 82. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16293/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source